The Molecular Mechanism of Honokiol Inhibits TNFα /Nur77 Survival Pathway

在许多肿瘤组织中，肿瘤坏死因子α能够促进肿瘤细胞生存和增殖。通常，在肿瘤微环境中肿瘤坏死因子α的主要来源是多种定向分化的巨噬细胞，而肿瘤坏死因子α可以激活NF-κB以及MAPK等信号通路促进肿瘤细胞的生存。本文研究核受体Nur77在肿瘤坏死因子α相关的生存通路中的作用及和厚朴酚通过下调核受体Nur77蛋白水平抑制肿瘤坏死因子α介导的生存通路。 依据天然产物和厚朴酚治疗各种疾病的多效性，抑制肿瘤细胞增殖的高效性及治疗癌症的临床数据，结合和厚朴酚作为视黄醇X受体α的天然配体调控视黄醇X受体α转录活性的机制研究的提示，我们开展了本课题的研究工作。肿瘤坏死因子α通过肿瘤坏死因子受体通路诱导肿瘤细胞细...In the many tumor tissues,tumour necrosis facror α(TNFα) can promote tumour cells to survive and proliferate. Generally, in the tumour microenvironment, the source of tumor necrosis factor α are many orientation differentiation macrophages. Tumor necrosis factor α could activate NF-κB and MAPK (Mitogen-activated protein kinase) signaling pathways to improve the survival of tumor cells .This paper ...学位：理学硕士院系专业：药学院_化学生物学专业学号：3052009115223

Effect of revolution speed on microstructure and microhardness of Cu spencimens subjected to high-pressure torsion

通过高压扭转(HPT)技术在不同转速条件下实现了Cu试样的晶粒细化.利用光学显微镜(OM),透射电镜(TEM)及显微硬度计观察并测试了组织的结构与性能,并基于有限元计算了变形诱导试样的温升,研究了转速对Cu试样的组织细化与性能的影响.结果表明:转速由1/3r.min-1增大至1r.min-1,经1圈扭转变形,试样温度由40.8℃升高到54.1℃,变形组织均为100~600nm的高位错密度位错胞/亚晶组织,显微硬度由初始态的52HV0.05增大至140HV0.05;经16圈扭转变形,试样温度由50.4℃升高到97.4℃,组织细化到200nm.慢速扭转变形试样晶内位错密度高,微观组织处于严重变形状态;而快速扭转试样晶内衬度均匀,位错较少,微观组织经历明显的动态回复,显微硬度较慢速扭转变形试样低6

电化学探针技术测量电生刻蚀剂的浓度分布

建立了电化学探针技术检测电生刻蚀剂测量系统，利用该测量系统对在模板表面上电生刻蚀剂溴的微米级浓度分布进行了定量研究

PLC在电厂电动机星-三角启动中的应用

文章简要介绍了PLC星三角降压启动原理及应用程序软件。由于PLC与传统继电器在电动机启动方面相比具有显著的优势,抗振性(AC)和电磁兼容性(EMC)好,冲击电流小等,可靠性、稳定性和安全性都更高。据此详细介绍了西门子PLC在电动机星-三角启动中的应用。对于PLC在相关行业和领域电动机启动的应用有着较强的通用性与参考价值

利用约束刻蚀剂层技术提高硅的刻蚀分辨率(英文)

高分辨率刻蚀技术对于微机械及微电子器件的加工具有十分重要的意义，而硅是其中极为重要并占统制地位的材料。近年来，扫描电化学显微镜（ＳＥＣＭ）用于表面加工的研究颇受注目。然而，ＳＥＣＭ刻蚀分辨率往往因为刻蚀剂的横向扩散而受到限制。最近，田昭武等提出的一种可进行高分辨率微加工的新方法——约束刻蚀剂层技术（ＣＥＬＴ），可使刻蚀反应具有高度的距离敏感性，刻蚀分辨率得到极大改善。我们利用ＣＥＬＴ技术刻蚀硅表面，以６０μｍ及１００μｍ直径微电极产生刻蚀剂Ｂｒ２，刻蚀溶液中加入亚砷酸作为Ｂｒ２的捕捉剂刻蚀得到的图案与所用微电极尺寸符合，直径分别约为６０μｍ和１００μｍ。与ＳＥＣＭ方法得到的１１０μｍ和１８０μｍ分辨率相比，刻蚀分辨率得到大幅度提高。作者联系地址：厦门大学化学系,哈尔滨工业大

和厚朴酚调控P38信号通路诱导人宫颈癌Hela细胞凋亡的实验研究

目的探讨和厚朴酚诱导人宫颈癌Hela细胞的凋亡及激活P38信号通路之间的关系。方法采用细胞培养技术,用一定浓度的药物处理细胞。应用蛋白印迹技术检测聚腺苷二磷酸核糖聚合酶(PARP)及其切割蛋白水平,聚腺苷二磷酸核糖聚合酶切割蛋白的出现代表细胞起始凋亡;应用蛋白印迹技术检测P38蛋白的磷酸化水平,P38蛋白的磷酸化水平的上调表示P38信号通路的激活。利用抑制剂SB203580阻断P38信号通路,通过这个方法检测和厚朴酚诱导细胞凋亡的变化情况。结果和厚朴酚激活P38信号通路与诱导细胞凋亡之间有一定联系。结论和厚朴酚通过调控P38信号通路诱导Hela细胞的凋亡

Research of pharmacological effect basis of usual clinical medications with camellia oil

目的探讨茶油多种临床用药可能的药理药效基础。方法将油茶籽经两次95%的乙醇回流提取后浓缩至不含乙醇和水的提取物,取其中的茶油部分作为试验药物;用肿瘤坏死因子-α(Tnf-α)处理人乳腺癌细胞系(MCf-7)细胞建立细胞炎症模型,进一步用蛋白质印迹技术观察药物处理对细胞炎症因子Iκb-α表达的影响进而评价茶油是否具有抗炎活性。结果从油茶籽提取得到的茶油显著地抑制细胞中Tnf-α诱导的Iκb-α的降解从而抑制炎症发生。结论茶油对细胞显示良好的抗炎作用,这种特性可能是其临床应用于治疗皮肤过敏、暗疮、疥癣、小儿红屁股、以及皮肤烧烫伤等多种与炎症相关疾病的药理基础之一。Objective To explore the possible pharmacological effect basis of usual clinical medications with camellia oil.Methods After twice 95% ethanol reflux extraction of camellia seed, the solution was concentrated to the extractive without ethanol and water.Camellia oil in the extractive was taken as study drug.Human breast adenocarcinoma cell line(MCF-7) cell was managed by tumor necrosis factor(TNF)-α to build a cell inflammation model.Influence of drug treatment on cell inflammatory cytokines IκB-α was observed by Western blot, in order to make evaluation on whether camellia oil possesses anti-inflammatory activity.ResultsCamellia oil extracted from camellia seed had significantly inhibiting effect on degradation of IκB-α induced by TNF-α, so as to suppress occurrence of inflammation.Conclusion Camellia oil has precise anti-inflammation effect on cells, and this effect may be one of its pharmacological basis for treating inflammation related diseases as skin allergy, pimples, scabies, pediatric bunda vermelha, skin burn and scald.厦门市科技计划项目(项目编号:3502Z20123015); 国家自然科学基金(项目编号:81102332

高指数晶面裸露的贵金属纳米晶体的合成

由于在高指数晶面上存在高密度的台阶位、扭结位原子等,高指数晶面裸露的贵金属纳米晶体一般表现出优越的物理化学性能,在催化、电化学等方面都有很重要的应用前景.近年来,研究人员围绕高指数晶面的制备进行了大量的工作并取得了一定进展.本文重点从合成制备方法的角度出发,结合本课题组的相关研究,系统总结了现有的有关制备高指数晶面裸露的贵金属纳米晶体的一些最新研究成果.从电化学方法、"帽"式试剂保护法、欠电位沉积原子层保护法、动力学调控、氧化刻蚀溶解再生长法以及模板法等几个方面对现有的高指数晶面裸露的贵金属纳米晶体的制备进行了总结

Facile syntheses and enhanced electrocatalytic activities of Pt nanocrystals with {hkk} high-index surfaces

通讯作者地址: Jiang, ZY (通讯作者),Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 2. Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 电子邮件地址: [email protected]; [email protected] (Pt) is an outstanding catalyst for many important industrial products. Because of its high cost and scarce reserves, it is very important to improve the performance of Pt catalysts. As the metal nanocrystals (NCs) with high-index surfaces usually show very good catalytic activity because of their high density of atomic steps and kinks, the preparation of Pt NCs with high-index facets has become a very important and hot research topic recently. In this article, we report a facile synthesis of high-yield Pt NCs with a series of {hkk} high-index facets including {211} and {411} via a solvothermal method using Pt(II) acetylacetonate as the Pt source, 1-octylamine as the solvent and capping agent, and formaldehyde as an additional surface structure regulator. Multipod Pt NCs with dominant {211} side surfaces were produced without formaldehyde, while concave Pt NCs with dominant {411} surfaces formed under the influence of formaldehyde. By analyzing the products by IR spectroscopy, we found the presence of CO on the surface of concave Pt NCs with {411} surfaces prepared from the solution containing formaldehyde. It was concluded that amine mainly stabilized the monoatomic step edges, resulting in the {211} exposed surface; with addition of formaldehyde, it decomposed into CO, leading to the formation of {411} surfaces by the additional adsorption of the CO on the {100} terraces. In addition, it was found that the as-prepared Pt NCs with high-index {211} and {411} surfaces exhibited much better catalytic activity in the electro-oxidation of ethanol than a commercial Pt/C catalyst or Pt nanocubes with low-index {100} surfaces, and the catalytic activities of Pt crystal facets decreased in the sequence {411}>{211}>{100}.National Basic Research Program of China 2011CBA00508 National Natural Science Foundation of China 21131005 21021061 21073145 21171141 National Fund for Fostering Talents of Basic Science J1030415 Key Scientific Project of Fujian Province of China 2009HZ0002-

俄罗斯公司低碳转型的区域决定因素： 人力资本和数字化对二氧化碳管理实践的影响

Received February 15, 2021; accepted March 19, 2022.Дата поступления 15 февраля 2021 г.; дата принятия к печати 19 марта 2022 г.Objective. The purpose of this article is to identify the regional determinants of the low carbon transition in Russian companies. These determinants are related to human capital and digital technologies development in local economic ecosystems. Methods. The study relies on linear regression methods and examines the impact of education, wages, the use of the broadband Internet, cloud technologies and ERP (Enterprise Resource Planning) systems in Russian regions on companies’ motivation to manage their carbon dioxide emissions. Results. The results show that human capital has an ambiguous effect on the behavior of companies that support the low carbon transition. On the contrary, the digitalization of regions is significantly and positively associated with the implementation of environmental and energy management practices in Russian companies, especially among service companies. Conclusion. Low carbon transition is becoming an essential component of the national development strategy, as climate resilience issues directly affect the economic performance of production systems. The study considers two types of factors that influence the implementation of management practices for the low-carbon transition: these are human capital and the digitalization of regions.Цель исследования. Целью данной статьи является выявление региональных детерминант низкоуглеродного перехода в российских компаниях. Эти детерминанты связаны с развитием человеческого капитала и цифровых технологий в локальных экономических экосистемах. Данные и методы. Исследование опирается на методы линейной регрессии и изучает влияние образования, заработной платы, использования широкополосного Интернета, облачных технологий и систем ERP (Enterprise Resource Planning) в регионах России на мотивацию компаний управлять своими выбросами углекислого газа. Результаты. Результаты показывают, что человеческий капитал оказывает неоднозначное влияние на поведение компаний, поддерживающих низкоуглеродный переход. Наоборот, цифровизация регионов существенно и положительно связана с внедрением практик экологического и энергетического менеджмента в российских компаниях, особенно среди сервисных компаний. Выводы. Переход к низкоуглеродному режиму становится важным компонентом национальной стратегии развития, поскольку вопросы устойчивости к изменению климата напрямую влияют на экономические показатели производственных систем. В исследовании рассматриваются два типа факторов, влияющих на реализацию управленческих практик низкоуглеродного перехода: это человеческий капитал и цифровизация регионов.研究目标：本文的目的是确定俄罗斯公司低碳转型的区域决定因素。这 些决定因素与当地经济生态系统中人力资本和数字技术的发展有关。数据与方法：该研究基于线性回归方法，考察了俄罗斯地区的教育、工 资、宽带互联网的使用、云技术和 ERP（企业资源规划）系统对企业管 理碳排放的积极性影响。 研究结果：结果表明，人力资本对低碳转型公司的行为具有矛盾影响。 相反，地区的数字化对俄罗斯公司引入环境和能源管理实践有着积极作 用，尤其是在服务公司中。 结论：低碳转型正在成为国家发展战略的重要组成部分，因为气候变化 问题直接影响生产系统的经济绩效。该研究考虑了影响低碳转型管理实 践实施的两类因素：人力资本和区域数字化