格列卫联合异基因造血干细胞移植治疗慢性粒细胞白血病

目的:为了考察格列卫联合异基因造血干细胞移植治疗慢性粒细胞白血病(CML)对移植及造血重建的影响。方法:对6例CML患者于移植前6周开始口服格列卫600~800mg/d至移植当日,预处理方案是福达拉宾、白消安、环磷酰胺,人类白细胞抗原(HLA)不相合者加用抗胸腺细胞球蛋白。移植物抗宿主病防治采用环孢素A加短程甲氨喋呤加霉酚酸酯。结果:6例全部成功植入,WBC>0.5×109·L-1平均为14.2d,PLT>20×109·L-1平均为15.6d。结论:CML患者移植前给予大剂量格列卫治疗不影响干细胞植入和骨髓造血的恢复

长江干流关键点流量变化及其生态影响分析

文章详细介绍了水文变动指标IHA法32个水文参数及其生态影响,计算分析了长江干流4个关键点寸滩、宜昌、汉口和大通在"自然变化阶段"、"受人类活动干扰阶段"和多年长系列3个不同时期的多年平均月流量状况,并采用IHA法计算了各控制点的32个水文参数,确定了各参数相应的水文变化等级,分析了长江干流流量格局的变化情况及潜在的生态影响。结果表明,长江干流关键点流量格局的变化主要是:年内月平均流量1～4月枯季流量增加,6～7月汛期流量增加;寸滩和宜昌流量减少主要集中在下半年8～11月,汉口和大通流量减少的时间推迟,

底吹氧气连续炼铅模型实验研究(一)底吹枪距与隔墙的合理布置

本文对氧气底吹连续炼铅过程中底吹喷枪的合理布置及隔墙位置的选择进行了模型实验研究。整个试验过程实现了用微机控制采样及数据处理、作图等实时处理。用 Navier-Stokes 方程及相似分析相结合的办法提出了枪距布置合理指数 S/W 与修正的 F'r 准数和几何相似准数 H/D 及 W/D 的函数关系式。按此关系进行了一系列试验得出准数方程如下S/W=26.224(W/D_0)~(-0.629)·(F'r)~(0.122)·(H/D)~(0.523)为了证实上述关系式是否可用,又用 DI SA 热膜探针测定了熔池二维流场,将测得的搅拌范围边界曲线延长至液面可得到搅拌直径 S,两种方法所得结果比较一致。测定了 RTD 曲线并用湍流扩散模型研究了隔墙的合理位置。根据本研究对该过程提出了改进建议

氧气底吹连续炼铅模型实验研究——Ⅱ——隔墙的合理布置

本文通过湍流扩散模型研究了氧气底吹连续炼铅 QSL 炉中的隔墙位置,底吹气体流量精矿, 流量及隔墙洞口面积对混匀时间。停留时间及 Peclet 返混准数的影响。试验表明;目前的 QSL 炉中,由于还原段中渣—铝分离需要较长的沉降时间,造成精矿,在氧化段停留时间过长,因此大大限制了氧化段的生产能力。而且氧化段中存在较大的死区。因此,在保证隔墙不受到氧气射流直接冲击条件下,应把隔墙向前布置,这将加强氧化段的混合,减少精矿在氧化段的停留时间或是把氧化段,还原段与沉降段分开,在还原段后设置一个沉降槽,这不仅缩短了整个炉子的长度,还可大大提高氧化段和还原段的生产能力,也有利于渣—铅分离

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies