Development and Experiment of Green Cutting Device

该金属切削装置基于绿色制造技术,通过绿色金属切削加工实验,用显微技术对加工结果进行工艺分析,表明该装置使用微量绿色金属切削液,能够取得与传统湿切削相同的加工性能,减少环境污染,降低加工成本。Green manufacturing technology based on the metal cutting device,through the experiment of green metal cutting,using micro technology on processing results for process analysis,show that the device using micro green metal cutting fluid,can be achieved with traditional wet machining the same performance,reduce environmental pollution,reduce processing costs

Diagnosis of meningeal carcinomatosis by copy number variation analysis based on cerebrospinal fluid metagenome next-generation sequencing

病史摘要 患者，男性，60岁，因&quot;头晕、头痛2个月余&quot;入院。 症状体征 患者近2个月逐渐出现头晕、头痛、恶心、呕吐、视力下降。既往史：明确诊断肺腺癌，伴肺内转移和多发骨转移，一直规律抗肿瘤治疗。体格检查：生命体征平稳，右肺呼吸音低，心、腹查体无殊，四肢肌力正常，病理征阴性，脑膜刺激征阴性。 诊断方法 脑脊液细胞学提示异型细胞。我们采用脑脊液宏基因组二代测序，对人源序列进行染色体拷贝数分析，提示异常非整倍体，符合恶性肿瘤。根据临床表现、脑脊液细胞学以及二代测序结果，确诊脑膜癌病&mdash;&mdash;肺癌脑膜转移。 治疗方法 行肿瘤靶向治疗、鞘内注射化疗药物等抗肿瘤综合治疗。 临床转归 头晕、恶心等症状较前明显好转。 适合阅读人群 神经科；检验科；呼吸科；肿瘤科</p

Detection of meningeal carcinomatosis by metagenomic next-generation sequencing and copy number variation analysis of cerebrospinal fluid

摘要 目的初步探索通过脑脊液宏基因组二代测序（mNGS）联合染色体拷贝数变异（CNV）分析技术对脑膜癌病辅助诊断的意义。 方法连续入组北京协和医院神经科2022年3月至2022年6月确诊的10例脑膜癌病患者。脑膜癌病的诊断依据中华医学会神经病学分会感染性疾病与脑脊液细胞学学组《脑膜癌病诊断专家共识》的标准，经脑脊液细胞学确诊。采用脑脊液mNGS病原微生物与CNV双组学检测。对照组为中枢神经系统炎性疾病患者，包括自身免疫性脑炎与病毒性脑炎，共10例。 结果入组的10例脑膜癌病患者中，肿瘤来源包括乳腺癌4例、肺癌6例。脑脊液mNGS联合CNV检测结果8例阳性，检测到非整倍体CNV，支持脑膜癌病的诊断；阳性率为8/10，阳性患者的肿瘤来源包括肺癌4例、乳腺癌4例。脑脊液CNV阴性患者2例，均为肺癌。全部患者脑脊液mNGS病原微生物分析结果均阴性；对照组CNV分析结果无阳性病例。 结论脑脊液CNV可作为脑膜癌病的诊断标志物，mNGS联合CNV对诊断脑膜癌病具有较高的阳性率，病原微生物与CNV的双组学联合分析的检测策略有助于拓宽脑脊液mNGS在临床辅助诊断的应用范围。</p

Measurement and assessment of psychological pain

摘要：&nbsp;心理痛苦是一种主观体验，主要来自于受挫的心理需求。其特征是对自我及其功能的消极变化的感知，伴随着强烈的消极情绪。心理痛苦常与心理健康水平下降有关，被认为是自杀过程的核心，更高的心理痛苦水平与自杀意念和自杀行为密切相关。因此，对心理痛苦的测量评估在门诊筛查、临床治疗、危机干预中有着重要作用。为了提高心理痛苦的识别和自杀风险预测的准确性，经过二十多年的应用与发展，已有十余种测量心理痛苦的方法可以纳入临床风险评估。传统的评估方法较多基于Shneidman对心理痛苦的定义及其自杀理论，用于测量心理痛苦的强度和频率。近年来自杀模型和理论的发展，为心理痛苦的评估提供了新的视角和理论基础。最新的评估方式趋向于更简短、便利的操作，或呈现心理痛苦的具体临床特征。此外，主题统觉测试、视觉模拟量表、疾病和自我的图示表征测量、结构化访谈等形式，弥补了自我报告的局限性。未来可以进一步结合神经生物技术，移动互联网等手段进行评估，同时考虑在特殊人群和跨文化群体等多元环境中的应用。</p

Clinical analysis of anti-N-methyl-D-aspartate receptor encephalitis patients with cerebellar ataxia

摘要：&nbsp;目的:分析总结合并小脑共济失调的抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎患者的临床特点。方法:回顾分析北京协和医院2011&mdash;2019年诊治的抗NMDAR脑炎患者中合并小脑共济失调患者的临床表现、实验室检查结果、治疗与预后。结果:347例抗NMDAR脑炎患者中共有15例（4.3%）合并小脑共济失调，其中1例患者合并卵巢畸胎瘤，男性7例，女性8例，中位年龄28岁，从脑炎发病到出现小脑症状平均病程30.8 d，极期改良Rankin量表（mRS）评分平均3.73分，脑脊液白细胞中位数28&times;10 6/L。15例患者均接受了一线免疫治疗，1例患者接受了利妥昔单抗二线免疫治疗，9例患者接受了吗替麦考酚酯长程免疫治疗。随访时间7~66个月，末次mRS评分平均2.73分，预后良好者（mRS评分&le;2分）6例（6/15） 。结论:抗NMDAR脑炎合并小脑共济失调者相对少见，此类患者在神经功能方面预后较差，应及时识别抗NMDAR脑炎患者的小脑共济失调症状，采用规范的免疫治疗方案和长程免疫治疗，以期改善预后。</p

Oxidation of Cyclohexene to Adipic Acid Catalyzed by Peroxopolyoxo Complexes

[中文文摘]合成了一系列过氧杂多化合物,考察了其在环己烯氧化合成己二酸反应中的活性。结果表明,过氧磷钨十六烷基三甲基铵在环己烯氧化合成己二酸的过程中显示了较高的催化活性,反应6h,己二酸的收率可达55 9%。考察了温度、时间、反应物加入量、H2O2加入量、催化剂加入量等一系列条件对反应的影响,确定了最佳反应条件。[英文文摘]A series of peroxopolyoxo complexes had been synthesized,using 30% aqueous hydrogen peroxide (30% H2O2) as oxidant.Oxidation of cyclohexene to adipic acid catalyzed by various peroxopolyoxo complexes were investigated.Catalytic activity of cetyltrimethylammonium peroxotungstophosphate for oxidation of cyclohexene to adipic acid was very high.After reaction for 6 h,yield of adipic acid was up to 55.9%.Effects of reaction temperature,reaction time,amount of catalyst,H2O2,cyclohexene were also studied. Optimal reaction conditions were suggested.海南省自然科学基金(29902); 海南省教育厅科研基金(Hjkj200219)资助项目

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies