肌红蛋白的电喷雾质谱研究——推荐一个化学生物学教学实验

在原有实验的基础上,设计、实践了一个利用电喷雾质谱研究生物大分子与小分子相互作用的更为合理、简单、易行的实验方法。讨论了该实验在化学生物学专业本科生教学工作中的实践效果及经验

A standardized checklist on meta-analysis reporting in the open science era

荟萃分析(又称元分析)以量化方式综合实证研究结果,是积累整合证据并推进基础与应用研究的重要工具.在开放式科学这种新型研究实践下,荟萃分析是整合开放数据、进行科学推断的重要手段.但荟萃分析的过程繁复、方法多样,其执行上的严谨性对荟萃分析质量影响较大,因此报告的透明性和开放性对其结果的可重复性尤为重要.为了解中文荟萃分析报告规范性的现状,让更多研究者了解荟萃分析报告的规范性与透明性,提升荟萃分析报告的质量,本文以国际学界广泛使用的系统综述和荟萃分析优先报告条目(Preferred Reporting Items for Systematic reviews and Meta-Analyses, PRISMA)以及开放式科学理念为基础,结合基于效应量的荟萃分析报告特点,拟定《开放与可重复荟萃分析的报告清单》(Preferred Reporting Items for Open and Reproducible Metaanalysis, PRIOR-MA),并以心理学中的荟萃分析为例,对近五年国内发表的68篇中文荟萃分析的方法和结果部分进行回顾.基于结果,本文建议荟萃分析报告需要在以下方面进一步加强其开放性与透明性:文献搜索的时间及限制、研究筛选和数据收集过程的细节、文章筛选的流程图、效应量转换的细节、单个研究偏倚状况的评估等.本文为开放式荟萃分析提供了一个较为全面的报告清单(PRIOR-MA),为未来荟萃分析研究提供了参考.</p

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies