CT三维重组诊断寰枢关节不全脱位的实验及临床研究

目的比较寰枢关节的影像检查方法及技术,评价CT三维重组(CT3D)诊断寰枢关节不全脱位的临床价值。方法实验研究寰枢关节骨标本1套,模拟出寰枢关节正常及脱位的模型,进行X线、常规CT及CT3D检查。前瞻性分析影像学特点及诊断准确率。临床患者87例进行中立位CT3D检查,其中28例加行左、右旋转位。分析CT3D显示脱位征象的特点及诊断寰枢关节不全脱位的临床效果。结果实验组CT3D能清楚、直观的显示寰枢关节不全脱位各种征象,诊断准确率达100%。表面阴影法(SSD)CT3D显示寰枢外侧关节面错位最清楚,寰椎下关节面错位程度测量值与标本测量值差异无统计学意义(P>0.05)。87例患者中诊断为寰枢关节不全脱位72例,其中旋转型脱位52例,前脱位13例,后脱位7例。中立位显示寰枢外侧关节面错位72例,旋转位显示为旋转固定8例,旋转不对称15例。结论CT3D能显示寰枢关节不全脱位的各种征象,特别是寰枢外侧关节面错位。其中SSD法3D较X线、常规CT的诊断准确率高,具有成为诊断寰枢关节不全脱位金标准的条件

间充质干细胞在器官移植中发挥免疫抑制作用及机制探讨的研究进展

器官移植是终末期器官衰竭患者最有效的治疗手段。将间充质干细胞(MSC)用于器官移植已成为细胞疗法的重要组成部分。然而,MSC发挥免疫抑制作用的机制还有待进一步地挖掘,且影响MSC发挥免疫抑制作用的因素很多,这些原因导致MSC难以达到预期疗效。在本综述中将通过介绍MSC的免疫抑制作用及机制、影响MSC发挥免疫抑制作用的因素以及MSC的临床应用等方面来阐述MSC在器官移植领域的研究进展。国家重点研发项目(2018YFA0108304)国家自然科学基金(81771721、81671583

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies