健康食品ワイルドヤム中のジオスゲニンおよびジオスシン含有量

We investigated the contents of major active ingredient diosgenin and toxic ingredient dioscin in 6 products of Wild Yam supplements by HPLC. The diosgenin was at the level of ND (not detected)～90.2 mg/g, and the dioscin was at the level of ND～13.3 mg/g. The intake of diosgenin and dioscin for one day were 0.43～45.1 mg/ day and 1.4～15.9 mg/day, respectively. Toxicological studies have shown that dioscin causes hemolysis and vomiting in humans. Therefore, the possibility of excessive intake of dioscin from Wild Yam supplements should be considered

Clinical analysis of perimenopausal women presenting initially with dry eye symptom

目的探讨围绝经期妇女的干眼症状与干眼病诊断的相关性。方法分析56例具有干眼症状的围绝经期妇女眼部检查的临床资料,观察主诉为干眼症状患者的干眼病确诊率及其关系。结果56例以干眼症状为主要表现的围绝经期妇女,确诊水液缺乏型干眼17例(30.4%),蒸发过强型干眼12例(21.4%),混合型干眼8例(14.3%);不能诊断干眼病的19例(33.9%),最终诊断为围绝经期综合征。结论围绝经期妇女干眼病确诊率较高(66.1%),但部分干眼症状可以只是围绝经期综合征的精神神经症状的一种表现,临床诊断干眼应慎重。 【英文摘要】 Objective Diagnosis and treatment of dry eye are important for improving living quality.Present paper was to investigate the correlation between dry eye manifestations and diagnosis of dry eye disease in perimenopausal women.MethodsThe clinical data of 56 perimenopausal women presenting initially with dry eye symptoms including ocular symptoms,slit-lamp examination,tear film break-up time,basal and reflex Schirmer test,vital staining(fluorescence and rose bangle),and meibomian gland dysfunction examination ..

ウスバサイシンの市販品と栽培品中のアリストロキア酸の分析

We investigated by HPLC the content of aristolochic acid I, a nephrotoxic and carcinogenic ingredient in commercial Asiasarum siebldii, Asiasarum siebldii cultivated in the greenhouse, Asiasarum siebldii cultivated in the plant factory under LED light, and pharmacopoeial asiasarum root. Aristolochic acid I content in aerial parts in commercial plants (6 products), the greenhouse cultivated plants (n = 3) and the plant factory cultivated plants under LED light (n = 3) was 8.9～84, 8.0 and 27 μg/g in average respectively, while aristolochic acid I was not detected in these underground parts and pharmacopoeial asiasarum root. According to clinical finding, aristolochic acid caused nephropathy in humans at the range of 3.1～233 μg/g in Chinese herbs, health foods and others. Therefore, the use of the aerial parts of Asiasarum sieboldii should be avoided to prevent the risk of health hazard

Effect of Soil Moisture Content on Growth, Crude Drug "Cho-to-ko" Yield and Oxindole Alkaloid Content of Uncaria rhynchophylla (B. LIVING SCIENCE)

Uncaria rhynchophylla was cultivated by using soil with various moisture contents (20,40,60,80 or 100% of the maximum moisture content retained by soil). Both growth and crude drug "Cho-to-ko" (dried stem with hooks of U. rhynchophylla) yield of the plant were in the following order : 60%> 80%> 40%> 100%> 20%, while oxindole alkaloid content of the stem was in the following order : 20%> 60%> 100%> 40%> 80%. It is concluded that moderately wet soil is suitable for cultivation of U. rhynchophylla, in spite of the description in a Chinese literature that sandy soil is good for cultivation of the plants

カブ ショウカカン センコウ ニ タイスル キュウセイ ハンパツセイ フクマクエン シュジュツ ニオケル ソウヘイサ ノ ゲンキョウ アンケート チョウサ ケッカ

Objective: To investigate the current ways of wound closure in acute pan-peritonitis surgery at the department of surgery, Shiga University of Medical Science and its affiliated hospitals. Patients and method: Questionnaire survey was conducted by the e-mail regarding the closure methods in surgery for acute pan-peritonitis due to lower gastrointestinal perforation in the department of surgery, Shiga University of Medical Science and its affiliated hospital from January 2013 to June 2017. Result: Responses were obtained from 19 hospitals. The total surgical operation was 369 cases, and the number of cases for each facility was 0 to 186 cases. As for closure of the abdominal wall, 13 facilities (87%) did interrupted suture of peritoneum and fascia with monofilament absorbing suture. Also, five facilities (26.3%) used triclosan-coated sutures for peritoneum and fascia. Skin sutures by nylon were the most frequent in 7 facilities (39%). One facility closed the wound skin a few days after the operation. Negative pressure wound therapy was conducted at 2 institutions, 24 cases (6.5% of the total). Discussion: Since the guidelines for surgical site infection have just changed, the method of wound closure after acute pan-peritonitis surgery varied depending on the facility. In the future, it is necessary to bundle the procedures of the wound closure to analyze the outcomes among the multiple facilities

イガン オヨビ ダイチョウガン ジュツゴ ニ ハッショウシタ Clostridium difficile カンセンショウ ノ ケントウ カンレン ビョウイン ニ オケル アンケート チョウサ ノ ケッカ カラ

Objective: Retrospectively, we evaluated clinical characteristics of Clostridium difficile infection (CDI) after surgery for the gastric and colorectal cancer. Methods: We surveyed the sum total of surgery for the gastric and colorectal cancer and picked out postoperative CDI in the Shiga University of Medical Science Hospital and affiliated hospitals in 2014. Results: The incidence of CDI after surgery for the gastric and colorectal cancer was 1.2%. In the Shiga University of Medical Science Hospital, CDI occurred in 27 inpatients in all wards, two of them affected CDI after gastrointestinal surgery. Conclusions: The incidence of CDI after gastrointestinal surgery in this study was low as well as past reports. In order to perceive precise incidence and clinical influence of CDI, we plan to conduct a perspective clinical trial in cooperation with affiliated hospitals