We investigated the contents of major active ingredient diosgenin and toxic ingredient dioscin in 6 products of Wild Yam supplements by HPLC. The diosgenin was at the level of ND (not detected)～90.2 mg/g, and the dioscin was at the level of ND～13.3 mg/g. The intake of diosgenin and dioscin for one day were 0.43～45.1 mg/ day and 1.4～15.9 mg/day, respectively. Toxicological studies have shown that dioscin causes hemolysis and vomiting in humans. Therefore, the possibility of excessive intake of dioscin from Wild Yam supplements should be considered
