ICIs-Related Cardiotoxicity in Different Types of Cancer

Immune checkpoint inhibitors (ICIs) are rapidly developing immunotherapy cancer drugs that have prolonged patient survival. However, ICIs-related cardiotoxicity has been recognized as a rare, but fatal, consequence. Although there has been extensive research based on different types of ICIs, these studies have not indicated whether cardiotoxicity is specific to a type of cancer. Therefore, we conducted a systematic review to analyze a variety of ICIs-related cardiotoxicity, focusing on different types of cancer. We found that the incidence of ICIs-related cardiac adverse events (CAEs) and common cardiotoxic manifestations vary with cancer type. This inspired us to explore the underlying mechanisms to formulate targeted clinical strategies for maintaining the cardiovascular health of cancer patients

PD-1/PD-L1 blockade accelerates the progression of atherosclerosis in cancer patients

PD-1(programed death-1)/PD-L1(programed death-1 ligand) blockade represents a major breakthrough of anti-cancer therapies, however, it may come with increased risk of cardiovascular morbidity, such as myocarditis, acute coronary syndrome, arrhythmias, etc. Although the PD-1/PD-L1 blockade-related acute coronary syndrome (ACS) is rare, it can be fatal. Previous studies have implicated a role of the PD-1/PD-L1 axis in the development of atherosclerosis. This review explores a hypothesis that PD-1/PD-L1 blockade accelerates the progression of atherosclerosis and promotes plaque rupture, by synthesizing the evidence of vascular inflammation, as well as plaque progression, destabilization and rupture via T-cell activation and effector function. In order to improve the prognosis of cancer patients and decrease the cardiotoxicity of PD-1/PD-L1 blockade therapy, early recognition of PD-1/PD-L1-blockade-related ACS is important. [Abstract copyright: Copyright © 2022. Published by Elsevier Inc.

PD-1/PD-L1 Blockade Accelerates the Progression of Atherosclerosis in Cancer Patients.

PD-1(programed death-1)/PD-L1(programed death-1 ligand) blockade represents a major breakthrough of anti-cancer therapies, however, it may come with increased risk of cardiovascular morbidity, such as myocarditis, acute coronary syndrome, arrhythmias, etc. Although the PD-1/PD-L1 blockade-related acute coronary syndrome (ACS) is rare, it can be fatal. Previous studies have implicated a role of the PD-1/PD-L1 axis in the development of atherosclerosis. This review explores a hypothesis that PD-1/PD-L1 blockade accelerates the progression of atherosclerosis and promotes plaque rupture, by synthesizing the evidence of vascular inflammation, as well as plaque progression, destabilization and rupture via T-cell activation and effector function. In order to improve the prognosis of cancer patients and decrease the cardiotoxicity of PD-1/PD-L1 blockade therapy, early recognition of PD-1/PD-L1-blockade-related ACS is important. [Abstract copyright: Copyright © 2022. Published by Elsevier Inc.

ICIs-related cardiotoxicity in different types of cancer

Immune checkpoint inhibitors (ICIs) are rapidly developing immunotherapy cancer drugs that have prolonged patient survival. However, ICIs-related cardiotoxicity has been recognized as a rare, but fatal, consequence. Although there has been extensive research based on different types of ICIs, these studies have not indicated whether cardiotoxicity is specific to a type of cancer. Therefore, we conducted a systematic review to analyze a variety of ICIs-related cardiotoxicity, focusing on different types of cancer. We found that the incidence of ICIs-related cardiac adverse events (CAEs) and common cardiotoxic manifestations vary with cancer type. This inspired us to explore the underlying mechanisms to formulate targeted clinical strategies for maintaining the cardiovascular health of cancer patients

Circular RNA hsa_circ_0051040 Promotes Hepatocellular Carcinoma Progression by Sponging miR-569 and Regulating ITGAV Expression

Accumulating evidence has demonstrated the roles of circular RNAs (circRNAs) in hepatocellular carcinoma (HCC); however, their roles in HCC need to be further studied. Through high-throughput human circRNA microarray analysis of HCC and adjacent normal tissues, we identified hsa_circ_0051040 as a novel candidate circRNA for the diagnosis and treatment of HCC. In this study, we found that hsa_circ_0051040 was overexpressed in HCC tissues and cell lines and that its expression was correlated with poor prognosis. Knockdown of hsa_circ_0051040 inhibited the migration, invasion, and proliferation of HCC cells in vitro and in vivo, whereas overexpression of hsa_circ_0051040 had the opposite effects. Moreover, our data demonstrated that hsa_circ_0051040 acted as a sponge for miR-569 to regulate ITGAV expression and induce EMT progression. Our findings indicated that hsa_circ_0051040 promotes HCC development and progression by sponging miR-569 to increase ITGAV expression. Thus, hsa_circ_0051040 is a good candidate as a therapeutic target

Foraminiferal responses to major Pleistocene paleoceanographic changes in the southern South China Sea

International audienceA detailed age model for core 17957‐2 of the southern South China Sea was developed based on δ18O, coarse fraction, magnetostratigraphy, and biostratigraphy for the last 1500 kyr. The δ18O record has clear ∼100‐kyr cycles after the Mid‐Pleistocene Revolution (MPR) at the entrance of marine isotopic stage (MIS) 22. Planktonic foraminifera responded to the MPR immediately, showing the increased sea surface temperature (SST) and dissolution after the MPR. Benthic foraminifera did not respond to it until the Brunhes/Matuyama boundary. Since the MPR, the depth of thermocline gradually became shallower until MISs 6–5. This major change within MISs 6–5 was also reflected in the decreased SSTs and increased productivity and Deep Water Mass. Thus two major Pleistocene paleoceanographic changes were found: One was around the MPR; the other occurred within MISs 6–5, which speculatively might be ascribed to the reorganization of surface and deep circulation, possibly induced by tectonic forces

DataSheet_1_Grain-size, coarse fraction lithology and clay mineral compositions of surface sediments from Ross Sea, Antarctica: implications for their provenance and delivery mode.xls

Knowledge on spatial distribution, provenance and delivery mode of surface sediment aids in interpretation of nearby sediment records for paleoenvironmental reconstruction. Such knowledge, however, remains largely unknown for the modern Ross Sea, Antarctica: a key region for understanding the dynamical behavior of Antarctic Ice Sheet over geological past. In this study, we address this gap by analyzing the grain-size distribution, coarse fraction (>250 μm) lithology, and clay mineralogy of a set of surface sediment samples covering the whole Ross Sea continental shelf. Our data reveals that the sediments were mostly delivered by icebergs and bottom currents. Iceberg delivery was significantly controlled by factors such as water depth, proximity to the iceberg sources, and invasion of the Modified Circumpolar Deep Water. Bottom current activity was stronger in the Western Ross Sea (WRS) than in the Eastern Ross Sea (ERS), controlled by the formation and transport of Dense Shelf Water. Three major sorts of coarse fraction were identified, including the quartz-rich Iceberg Rafted Detritus (IRD) originating from West Antarctic glaciers and primarily distributed in the ERS, the mafic rocks-rich IRD from the Ferrar Group as well as the McMurdo Volcanic Group and mainly found in the WRS, and deformed silt traced back to the grounding zone of the David Glacier-Dragalski Ice Tongue system. The distribution of clay minerals is dominated by a distinct binary mixing pattern. Smectite and kaolinite are mainly present in the ERS, derived from beneath the West Antarctic Ice Sheet. Higher illite and chlorite contents were found offshore of the Southern Victoria Land, derived from the East Antarctic craton. Overall, these results demonstrate that the glaciers draining into Ross Sea from both the East and West Antarctic Ice Sheets are highly dynamical in the context of modern climate conditions, with implications for potential contribution to future sea level rise.</p