Polypeptide Micelle-based Theranostic Nanoplatform for Overcoming Cancer Multidrug Resistance

癌症是全球范围内导致人口死亡的一个重要原因，在各种癌症中，胃癌是一 种较为高发的癌症，特别是在发展中国家。在发展中国家中，胃癌是造成男性死 亡的第三大死因。由于胃癌容易产生潜在的淋巴结转移，单纯的手术切除通常不 是很有效。因而，临床治疗过程中，常在手术切除肿瘤病灶后，常利用化学疗法 对晚期或是已经发生转移的胃癌进行治疗。化学疗法在癌症的治疗中已经得到广 泛的应用，但化学治疗的同时，也产生了一个新的问题，即癌细胞在经过化疗药 物治疗后，出现了耐药性。为了解决癌细胞对化疗药物耐药的问题，临床常选用 联用其他化学治疗药物或者增加化疗药物用量的方法，但这种方式并不能从根本 上解决耐药性...Cancer is the leading cause of death worldwide, and stomach cancer is one of the most frequently diagnosed ones. In less developed countries, stomach cancer is the third most frequently diagnosed cancer among men and the leading cause of cancer death. Owning to the suspected lymph nodes metastasis, sole surgical resection is usually not very effective. Therefore, chemotherapy has been widely used ...学位：医学硕士院系专业：公共卫生学院_流行病与卫生统计学学号：3272013115055

Study on the relationship between Recombinant Human Prothymosin α and cell proliferation,and as a tumor marker of urinary system

胸腺素α原是一种在体内广泛表达的小分子量强酸性蛋白质，进化上高度保守，分布极其广泛，淋巴组织及非淋巴组织均可找到，其相对分子质量为12.5k，基因定位于第2号染色体上。它除了具有促进机体免疫功能外，另一个重要功能是提高细胞的增殖能力，是细胞生长和存活不可缺少的；缺乏ProTα的细胞不能分裂。由于ProTα与细胞增殖相关，而肿瘤细胞具有强烈的增殖活性，因而ProTα在肿瘤进展中的作用成为研究焦点。ProTα参与肿瘤发生、细胞凋亡及转录调节。目前的研究主要集中于ProTα基因的调节机制及其在肿瘤诊断和治疗中的价值。 由于ProTα无二级结构，免疫原性差，很难制备出对它的单克隆抗体，本研究分别采用...Prothymosinα is a small molecular weight acidic protein ,and widely expressed in the body.ProTα evolutionarily conserved and Widely distributed. Its Molecular weight of 12.5k ,and gene located on chromosome 2. ProTα promoting immune function, another important function is to increase cell proliferation, cell growth and survival is essential;lack ProTα cells can not divide. ProTα associated with ce...学位：理学硕士院系专业：生命科学学院生物学系_水生生物学学号：2172008115252

Intervening measures for improper prescription in clinic:introduction and empirical analysis

目的:介绍福建省某三甲医院干预不合理处方的措施并进行分析,探讨提高处方质量的方法。方法:参照2010年2月10日卫生部印发的《医院处方点评管理规范(试行)》,结合本院近年来对不合理处方干预的资料与经验,深入分析各种不合理处方的干预措施及其综合应用的有效性。结果:处方自动监测系统(PASS)干预、审核药师审核退回、调配发药药师拦截、临床药师介入进行回顾性汇总分析、宣传教育行政干预等措施相结合是提高处方质量的有效方法。结论:不合理处方的干预要有统一可行的标准,医院通过各个环节紧密配合,临床药师介入处方干预的各个环节,配合行政干预,加强宣传教育,共同对不合理处方进行干预,有望在不合理处方干预方面取得成效。Objective:Intervening measures for improper prescription in a Three-A hospital of Fujian province was introduced and analyzed to discuss the approach improving the prescription quality.Methods: The data and experiences in our hospital in recent years were collected and analyzed.According to "Tentative Management Regulation of Prescription Comment in Hospital" issued by Ministry of Health,China on February 2010,various intervening measures for improper prescription were fully discussed.Results: Following measures could be integrated into application to improve prescription quality: intervene with prescription automatic screening system(PASS),withdraw after reviewed by a senior pharmacist,intercept by a dosage pharmacist,intervention through review analysis by clinical pharmacist,and administrative disturbance through health education.Conclusion: A uniform practicable standard is needed in the field of intervention for improper prescription.Cooperation between different sectors of a hospital,clinical pharmacist involvement in all phases of prescription intervention,assistant with administrative disturbance,and health education are expected to make progress in improving improper prescription

Experimental Study on Effects of Hypoglycemic and Antiobesity of L-Arabinose in New Zealand Rabbit

目的探讨l-阿拉伯糖对动物(新西兰兔)降血糖和减肥的作用。方法以高糖高脂饲料诱导新西兰兔肥胖模型,然后将其随机分为4组:模型对照组及l-阿拉伯糖低剂量(0.3085g/kg)、中剂量(0.617g/kg)、高剂量(0.9255g/kg)3个给药组。连续喂养2个月后,空腹12H,各给药组按剂量口服l-阿拉伯糖后2H,分别口服蔗糖0、0.5、2H测新西兰兔耳缘静脉血糖值;l-阿拉伯糖干预1个月时测体重、进食量和排便量、脂肪指数的变化。结果高、中、低l-阿拉伯糖组空腹血糖与模型对照组存在明显差异(P<0.05),在糖耐量作用中,l-阿拉伯糖各剂量组和模型对照组的曲线下面积(AuC)出现明显差别。在减肥功能的指标中(体重变化、日进食量和排便量、脂肪指数),l-阿拉伯糖各剂量组与模型对照组比较差异有统计学意义(P<0.05),其中l-阿拉伯糖组与模型对照组的脂肪指数具有显著差异(P<0.01)。结论l-阿拉伯糖有明显降血糖和减肥的作用。Objective To research the function of hypoglycemic and antiobesity of L-Arabinose in New Zealand rabbit.Methods Thirty-two New Zealand white rabbits were randomly divided into 4 groups, 8 rabbits in each group.The control group was fed with high fat and high sucrose diet only.L-Arabinose group was fed with high fat and high sucrose diet along with L-Arabinose, the dosage were 0.308 5, 0.617, 0.925 5 g/kg respectively.After fed for two months, all groups were given L-Arabinose, and blood glucose was detected after orally given sucrose 0, 0.5, 2 h.After intervention of L-Arabinose for one month, the data of weight, food intake, stool quantity and the fat index were observed.Results L-Arabinose decreased significantly sucrose absorption, lower the fasting glucose level and the data of area-under-curve (AUC) significantly.Conclusion L-Arabinose proved to be highly effective in preventing the rise of circulating glucose and fat

药理学实验教学改革与实践

为提高学生学习能力、思考能力、动手能力和创新能力,厦门大学医学院着力于药理学实验教学改革,从提高教师的专业素养、增强实验室硬件建设、改革实验教学内容、开展设计性实验四个方面阐述了药理学实验教学改革与实践的成果

支持权重优先等级的自适应接入机制

研究IEEE 802.11e协议中吞吐量权重比例公平性问题,提出基于业务负载增量估计算法的自适应分布式信道接入机制。给出竞争窗口(CW)关于业务负载线性调整规则,建立接入参数与动态网络条件的关联;提出业务负载的增量估计算法;通过引入优先等级因子参数和多阈值设置,支持吞吐量权重比例的优先等级(WPL)并获得更好的总吞吐量性能。CW决定了节点接入信道的概率,保证了吞吐量权重公平性性能。仿真结果表明了自适应接入机制的有效性和可扩展性。海南自然科学基金项目(617110、617121、618MS083);;\n国家自然科学基金项目(61362016、61502127、61562022、61562023);;\n国家国际科技合作专项基金项目(2014DFA13140);;\n海南省重大科技计划课题基金项目(ZDKJ2017012

肝癌发展中FasL及其受体Fas/DcR3的表达分析

目的研究小鼠肿瘤发生早期肿瘤坏死因子超家族成员FasL及其受体的表达特点,及其与免疫调节相关分子表达的时空关系,探讨其在诱导肿瘤免疫耐受中的作用。方法建立小鼠实体瘤模型,采用RT-PCR方法检测肿瘤组织中可溶型FasL、Fas及DcR3、TGF-β、IL-10在肿瘤发生不同时相的表达,同时,应用ELISA方法定量检测血清中TGF-β、IL-10的表达。结果在早期的肿瘤组织中,Fas的表达先于DcR3,其后DcR3大量表达,而Fas的表达则下调直至丢失,DcR3、FasL同时表达并上调,TGF-β和IL-10也随肿瘤的表达而上调。TGF-β同DcR3的表达具有空间位置的一致性。FasL、DcR3、TGF-β和IL-10的表达水平同肿瘤的生长呈正相关。结论随着肿瘤不断的生长,肿瘤局部的免疫应答逐渐趋向于负调节,FasL、DcR3在诱导肿瘤免疫耐受的过程中可能发挥着重要作用

Study on the prothymosin α as vaccine adjuvant of P.yoelii

目的:研究胸腺素α原(PrOTHyMOSInα,PrOTα)作为约氏疟原虫疫苗免疫佐剂的作用。方法:提取P.yOElII-17Xnl全蛋白作为抗原,用胸腺素α原作为免疫佐剂,免疫小鼠。具体方案为:昆明小鼠分为4组,每组6只,A组免疫P.yOElII-17Xnl全蛋白+PrOTα;b组免疫P.yOElII-17Xnl全蛋白;C组只注射PrOTα;d组为空白对照,以相同体积的生理盐水代替。免疫结束后感染致死的P.yOElII-17Xl,1x107个虫/只小鼠。结果:感染后的前10天A组小鼠疟原虫血症平均值要低于其他三组,且最终有3只小鼠存活下来,存活率50%,C组有一只小鼠存活,b、d组小鼠全部死亡。结论:用P.yOElII-17Xnl全蛋白做抗原,用PrOTα作为佐剂,比单独用P.yOElII-17Xnl全蛋白对小鼠有更好的免疫保护作用,提示了PrOTα可以成为一种有潜力的蛋白疫苗。Objective:To investigate the function of prothymosin α(ProTα) as vaccine adjuvant of P.yoelii.Methods:The mice were immunized with the total protein extracted from P.yoelii-17XNL as antigen,together with prothymosin α as adjuvant.Programs:Kunming mice were divided into A,B,C and D group.A group was immunized with P.yoelii-17XNL total protein and ProTα;B group was immunized with P.yoelii-17XNL;C group was only injected with ProTα;D group was the control,only injected with physiological saline.And then,the mice of each group was infected with P.yoelii-17XL,the dosage was 1×107/mice.Results:The parasitemia of A group-mice was lower than the other three groups in the first 10 days after infection,and eventually there were three mice survived in A group,the survival rate was 50%,one mouse survived in C group,all of mice in B group and D group died.Conclusion:Mice immunized with P.yoelii-17XNL total protein as antigen together with ProTα as adjuvants,had better immune protection than those immunized with P.yoelii-17XNL protein only.The present results suggest that the ProTα can act as a potential adjuvant in protein vaccine.厦门市科技项目(3502Z20083004);国家“973”项目(2007CB513103)资

CCCCC pentadentate chelates with planar Möbius aromaticity and unique properties

本课题充分发挥了厦门大学多学科协同研究优势，通讯作者为夏海平教授（合成、表征）、刘刚教授（生物医学应用）和吕鑫教授（理论计算）。合成实验和结构表征由朱从青（第一作者，目前在麻省理工学院、2005年诺贝尔化学奖得主Richard Schrock教授课题组从事博士后研究）完成；生物医学应用由杨彩霞（共同第一作者）、林凎、杨宇惠、王晓勇合作完成；理论计算由朱军、王永恒、朱从青完成。美国NIH的陈小元教授参与了生物医学应用的讨论。该研究工作得到国家自然科学基金委、科技部项目的支持。The coordinating atoms in polydentate chelates are primarily heteroatoms. We present the first examples of pentadentate chelates with all binding atoms of the chelating agent being carbon atoms, denoted as CCCCC chelates. Having up to five metal-carbon bonds in the equatorial plane has not been previously observed in transition metal chemistry. Density functional theory calculations showed that the planar metallacycle has extended Craig-Möbius aromaticity arising from 12-center–12-electron dπ-pπ π-conjugation. These planar chelates have broad absorption in the ultraviolet-visible–near-infrared region and, thus, notable photothermal performance upon irradiation by an 808-nm laser, indicating that these chelates have potential applications in photothermal therapy. The combination of facile synthesis, high stability, and broad absorption of these complexes could make the polydentate carbon chain a novel building block in coordination chemistry.the National Basic Research Program of China (nos. 2012CB821600 and 2014CB744503) , the National Science Foundation of China (nos. 21332002, 81422023, 51273165, 21490573, and 21573179)