目的探讨l-阿拉伯糖对动物(新西兰兔)降血糖和减肥的作用。方法以高糖高脂饲料诱导新西兰兔肥胖模型,然后将其随机分为4组:模型对照组及l-阿拉伯糖低剂量(0.3085g/kg)、中剂量(0.617g/kg)、高剂量(0.9255g/kg)3个给药组。连续喂养2个月后,空腹12H,各给药组按剂量口服l-阿拉伯糖后2H,分别口服蔗糖0、0.5、2H测新西兰兔耳缘静脉血糖值;l-阿拉伯糖干预1个月时测体重、进食量和排便量、脂肪指数的变化。结果高、中、低l-阿拉伯糖组空腹血糖与模型对照组存在明显差异(P<0.05),在糖耐量作用中,l-阿拉伯糖各剂量组和模型对照组的曲线下面积(AuC)出现明显差别。在减肥功能的指标中(体重变化、日进食量和排便量、脂肪指数),l-阿拉伯糖各剂量组与模型对照组比较差异有统计学意义(P<0.05),其中l-阿拉伯糖组与模型对照组的脂肪指数具有显著差异(P<0.01)。结论l-阿拉伯糖有明显降血糖和减肥的作用。Objective To research the function of hypoglycemic and antiobesity of L-Arabinose in New Zealand rabbit.Methods Thirty-two New Zealand white rabbits were randomly divided into 4 groups, 8 rabbits in each group.The control group was fed with high fat and high sucrose diet only.L-Arabinose group was fed with high fat and high sucrose diet along with L-Arabinose, the dosage were 0.308 5, 0.617, 0.925 5 g/kg respectively.After fed for two months, all groups were given L-Arabinose, and blood glucose was detected after orally given sucrose 0, 0.5, 2 h.After intervention of L-Arabinose for one month, the data of weight, food intake, stool quantity and the fat index were observed.Results L-Arabinose decreased significantly sucrose absorption, lower the fasting glucose level and the data of area-under-curve (AUC) significantly.Conclusion L-Arabinose proved to be highly effective in preventing the rise of circulating glucose and fat
