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病例180:78岁男性,头昏、周身乏力伴视物模糊1周

综合上述分析,面对这样一个同时合并大血管狭窄、心房颤动、蛋白尿、高Hcy的老年脑卒中个体,可以说,没有哪个指南和专家共识能够直接拿来指导治疗策略; 。必须综合考虑,权衡利弊,给予个体化的治疗。最终,拟将血压<150/90 mm; Hg作为该患者的目标血压。据此,给予联合应用beta受体阻滞剂、利尿剂和ARB进行治疗:美托洛尔缓释片23.75 mg,1次/d; +吲达帕胺2.5 mg,1次/d +坎地沙坦酯4; mg,1次/d,后坎地沙坦酯片加量至8mg,1次/d。患者2周后血压即控制在130~150/60~70 mm Hg,随访3个月,病情稳定

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies