Isatis tinctoria L. combined with costimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice

目的：这项研究的目标一是检测板蓝根化合物K对异型抗原预致敏小鼠脾脏中记忆性T细胞的体外同种反应性增殖强度的影响，目标二是检测K与效应性T细胞共刺激阻断剂联用，对二次同种异体心脏移植物存活时间的影响。目标三是探讨化合物K对二次同种异体心脏移植物可能的保护机制。 方法：皮肤移植小鼠再次心脏移植构建小鼠预致敏同种异体心脏移植模型，后联合应用板蓝根化合物K和共刺激通路阻断剂，观察移植物生存期的改变，并从记忆性T细胞和记忆性B细胞两个角度探讨其可能的作用机制。 结果：1、在体外试验中，我们发现化合物K可明显抑制异型抗原预致敏小鼠脾脏中记忆性CD4+和CD8+T细胞的同种异体反应强度。2、在体内试验中...Objective: The objectives of this study were three-fold. We wanted to first to determine whether the compound K could reduce memory T cell proliferation in a mixed lymphocyte reaction (MLR); second, to determine whether compound K combined with anti-CD154 and anti-LFA-1 mAbs could reduce the accelerated rejection response in alloantigen-primed mice model; and third, to investigate the mechanism of...学位：医学硕士院系专业：医学院临床医学系_外科学学号：2452008115345

The identity and differences of right colon cancer surgery CME between China and German

德国HOHEnbErgEr先生提出的结肠癌完整系膜切除(COMPlETE MESOCOlIC EXCISIOn,CME)手术概念,已逐渐得到我国外科医生的认可和重视。但右半结肠癌完整系膜的上缘和内侧缘在哪里更符合CME要求呢？d3手术作为右半结肠CME手术的方法合理吗？是否有更符合CME理念的右半结肠癌根治手术方法呢？笔者将腹腔镜右半结肠CME手术方法与HOHEnbErgEr先生的CME进行对比阐述,以探讨右半结肠CME手术方法的合理性。The concept of complete mesocolic excision(CME)in colon cancer surgery proposed by professor Hohenberger from German,has been accepted and valued by Chinese surgeons.However,how to determine the upper edge and medial edge of the complete mesocolic excision for right colon cancer(RCME),and which will be more consistent with the requirements of CME? Whether the D3 surgery(Hemicolectomy with D3 lymph node dissection)is a reasonable surgical approach to RCME or not? Are there other surgical approaches to the right colon cancer radical surgery which are more in line with the concept of CME? By comparing the author's surgical approach to laparoscopic complete mesocolic excision for right colon cancer( L-RCME) with Mr.Hohenberger's surgical method in CME,we investigate the rationality of surgical approach to the complete mesocolic excision for right colon cancer

蜂窩織炎性虫垂炎に併存した右卵巣腫瘍に対し腹腔鏡下同時手術を施行した1例

症例は43歳女性，以前から慢性虫垂炎の再燃を繰り返しており，右卵巣腫瘍も併存していたため腹腔鏡下同時手術の予定であった．数日前から下腹部痛が出現し慢性虫垂炎の再燃と診断し，緊急入院した．以前から再燃を繰り返していたことから保存的加療後も短期間に再燃する可能性が高く，卵巣および卵巣腫瘍に虫垂炎の炎症が波及し卵巣膿瘍を形成しうること，虫垂と右卵巣は同一術野で手術が可能であることから一期的に腹腔鏡下同時手術を行った．虫垂切除および右付属器摘出を行い，術後経過は良好で4日病日に退院となった．蜂窩織炎性虫垂炎は進行した場合に壊疽性虫垂炎や穿孔性虫垂炎に移行する．卵巣と虫垂は解剖学的に近接した臓器であり虫垂より炎症が卵巣に波及し卵巣膿瘍を形成することや，もともと卵巣腫瘍が存在する場合にも術後卵巣膿瘍を形成することがある．本例のように右卵巣腫瘍が併存する場合，同一術野で手術が可能であり，虫垂炎の炎症が波及するリスクを考慮し虫垂炎の程度などを評価した上で侵襲性を考慮し腹腔鏡下同時手術を考慮すべきである

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies