Existence of solutions for a class of fourth-order m-point boundary value problems

Some existence criteria are established for a class of fourth-order $m$-point boundary value problem by using the upper and lower solution method and the Leray-Schauder continuation principle

The upper and lower solution method for nonlinear third-order three-point boundary value problem

This paper is concerned with the following nonlinear third-order three-point boundary value problem \left\{ \begin{array}{l} u^{\prime \prime \prime }(t)+f\left( t,u\left( t\right) ,u^{\prime}\left(t\right) \right) =0,\, t\in \left[ 0,1\right], \\ u\left( 0\right) =u^{\prime }\left( 0\right) =0,\, u^{\prime}\left( 1\right) =\alpha u^{\prime }\left( \eta \right),\label{1.1} \end{array} \right. where $0<\eta <1$ and $0\leq \alpha <1.$ A new maximum principle is established and some existence criteria are obtained for the above problem by using the upper and lower solution method

Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model

The ARRIVE Guidelines Checklist. Animal Research: Reporting In Vivo Experiments. (PDF 391 kb

Two Energy Release Processes for CMEs: MHD Catastrophe and Magnetic Reconnection

It remains an open question how magnetic energy is rapidly released in the solar corona so as to create solar explosions such as solar flares and coronal mass ejections (CMEs). Recent studies have confirmed that a system consisting of a flux rope embedded in a background field exhibits a catastrophic behavior, and the energy threshold at the catastrophic point may exceed the associated open field energy. The accumulated free energy in the corona is abruptly released when the catastrophe takes place, and it probably serves as the main means of energy release for CMEs at least in the initial phase. Such a release proceeds via an ideal MHD process in contrast with nonideal ones such as magnetic reconnection. The catastrophe results in a sudden formation of electric current sheets, which naturally provide proper sites for fast magnetic reconnection. The reconnection may be identified with a solar flare associated with the CME on one hand, and produces a further acceleration of the CME on the other. On this basis, several preliminary suggestions are made for future observational investigations, especially with the proposed KuaFu satellites, on the roles of the MHD catastrophe and magnetic reconnection in the magnetic energy release associated with CMEs and flares.Comment: 7 pages, 4 figures, Adv. Spa. Res., in press

Spontaneous activities in baroreflex afferent pathway contribute dominant role in parasympathetic neurocontrol of blood pressure regulation

Aim To study the dominant role of parasympathetic inputs at cellular level of baroreflex afferent pathway and underlying mechanism in neurocontrol of blood pressure regulation. Methods Whole‐cell patch‐clamp and animal study were conducted. Results For the first time, we demonstrated the spontaneous activities from resting membrane potential in myelinated A‐ and Ah‐type baroreceptor neurons (BRNs, the 1st‐order), but not in unmyelinated C‐types, using vagus‐nodose slice of adult female rats. These data were further supported by the notion that the spontaneous synaptic currents could only be seen in the pharmacologically and electrophysiologically defined myelinated A‐ and Ah‐type baroreceptive neurons (the 2nd‐order) of NTS using brainstem slice of adult female rats. The greater frequency and the larger amplitude of the spontaneous excitatory postsynaptic currents (EPSCs) compared with the inhibitory postsynaptic currents (IPSCs) were only observed in Ah‐types. The ratio of EPSCs:IPSCs was estimated at 3:1 and higher. These results confirmed that the afferent‐specific spontaneous activities were generated from baroreflex afferent pathway in female‐specific subpopulation of myelinated Ah‐type BRNs in nodose and baroreceptive neurons in NTS, which provided a novel insight into the dominant role of sex‐specific baroreflex‐evoked parasympathetic drives in retaining a stable and lower blood pressure status in healthy subjects, particularly in females. Conclusion The data from current investigations establish a new concept for the role of Ah‐type baroreceptor/baroreceptive neurons in controlling blood pressure stability and provide a new pathway for pharmacological intervention for hypertension and cardiovascular diseases

Evaluation of a novel saliva-based epidermal growth factor receptor mutation detection for lung cancer: A pilot study.

BackgroundThis article describes a pilot study evaluating a novel liquid biopsy system for non-small cell lung cancer (NSCLC) patients. The electric field-induced release and measurement (EFIRM) method utilizes an electrochemical biosensor for detecting oncogenic mutations in biofluids.MethodsSaliva and plasma of 17 patients were collected from three cancer centers prior to and after surgical resection. The EFIRM method was then applied to the collected samples to assay for exon 19 deletion and p.L858 mutations. EFIRM results were compared with cobas results of exon 19 deletion and p.L858 mutation detection in cancer tissues.ResultsThe EFIRM method was found to detect exon 19 deletion with an area under the curve (AUC) of 1.0 in both saliva and plasma samples in lung cancer patients. For L858R mutation detection, the AUC of saliva was 1.0, while the AUC of plasma was 0.98. Strong correlations were also found between presurgery and post-surgery samples for both saliva (0.86 for exon 19 and 0.98 for L858R) and plasma (0.73 for exon 19 and 0.94 for L858R).ConclusionOur study demonstrates the feasibility of utilizing EFIRM to rapidly, non-invasively, and conveniently detect epidermal growth factor receptor mutations in the saliva of patients with NSCLC, with results corresponding perfectly with the results of cobas tissue genotyping

A simulation study on the measurement of D0-D0bar mixing parameter y at BES-III

We established a method on measuring the \dzdzb mixing parameter $y$ for BESIII experiment at the BEPCII $e^+e^-$ collider. In this method, the doubly tagged $\psi(3770) \to D^0 \overline{D^0}$ events, with one $D$ decays to CP-eigenstates and the other $D$ decays semileptonically, are used to reconstruct the signals. Since this analysis requires good $e/\pi$ separation, a likelihood approach, which combines the $dE/dx$, time of flight and the electromagnetic shower detectors information, is used for particle identification. We estimate the sensitivity of the measurement of $y$ to be 0.007 based on a $20fb^{-1}$ fully simulated MC sample.Comment: 6 pages, 7 figure

SDCL: Self-Distillation Contrastive Learning for Chinese Spell Checking

Due to the ambiguity of homophones, Chinese Spell Checking (CSC) has widespread applications. Existing systems typically utilize BERT for text encoding. However, CSC requires the model to account for both phonetic and graphemic information. To adapt BERT to the CSC task, we propose a token-level self-distillation contrastive learning method. We employ BERT to encode both the corrupted and corresponding correct sentence. Then, we use contrastive learning loss to regularize corrupted tokens' hidden states to be closer to counterparts in the correct sentence. On three CSC datasets, we confirmed our method provides a significant improvement above baselines