Synthesis of Kinetin-Analogues IV

In previous paper of this series it was reported that the kinetin-analogues which have an aromatic or heterocyclic ring instead of furane ring have almost the same activity as kinetin on leaf growth. In this paper a study was made to ascertain by what kinds of ring the furane ring might be replaced and the same activity as kinetin be still retained. Another study also was made to investigate the effect of carbon numbers between purine nucleus and attached benzene ring on the leaf-growth promoting activity of phenyl alkylamino-purine. The kinetin-analogues having 0, 1 and 2 carbon atoms have almost the same activity as kinetin. In the case of n=4 or 5 it has almost inactive. The analogues, having naphthalene, biphenyl, phenanthrene or anthracene ring, have lower activity than kinetin

第1063回千葉医学会例会・第1内科教室同門会例会

OBJECTIVE: Upregulation of the receptor for advanced glycation end products (RAGE) has been proposed as a pathophysiological mechanism underlying the development of atrial fibrillation (AF). We sought to investigate if soluble RAGE levels are associated with AF in Caucasian patients. METHODS: Patients (n = 587) were prospectively recruited and serum levels of soluble RAGE (sRAGE) and endogenous secretory RAGE (esRAGE) measured. The patients included 527 with sinus rhythm, 32 with persistent AF (duration >7 days, n = 32) and 28 with paroxysmal AF (duration <7 days, n = 28). RESULTS: Patients with AF were older and had a greater prevalence of heart failure than patients in sinus rhythm. Circulating RAGE levels were higher in patients with persistent AF [median sRAGE 1190 (724-2041) pg/ml and median esRAGE 452 (288-932) pg/ml] compared with paroxysmal AF [sRAGE 799 (583-1033) pg/ml and esRAGE 279 (201-433) pg/ml, p ≤ 0.01] or sinus rhythm [sRAGE 782 (576-1039) pg/ml and esRAGE 289 (192-412) pg/ml, p < 0.001]. In multivariable logistic regression analysis, independent predictors of persistent AF were age, heart failure, sRAGE [odds ratio 1.1 per 100 pg/ml, 95% confidence interval (CI) 1.0-1.1, p = 0.001] and esRAGE [odds ratio 1.3 per 100 pg/ml, 95% CI 1.1-1.4, p < 0.001]. Heart failure and age were the only independent predictors of paroxysmal AF. In AF patients, sRAGE [odds ratio 1.1 per 100 pg/ml, 95% CI 1.1-1.2, p = 0.007] and esRAGE [odds ratio 1.3 per 100 pg/ml, 95% CI 1.0-1.5, p = 0.017] independently predicted persistent compared with paroxysmal AF. CONCLUSIONS: Soluble RAGE is elevated in Caucasian patients with AF, and both sRAGE and esRAGE predict the presence of persistent AF

<原著>顎口腔領域悪性腫瘍の臨床統計的研究

Clinico-statistical observations were made of 48 cases of malignant tumors of the oral and maxillofacial regions from 1978 to 1995 at the Department of Oral Surgery, School of Dentistry, Health Sciences University of Hokkaido. The results were as follows: 1) Of 48 patients, 35 were male and 13 were female (2. 7:1). The mean age was 60. 7. 2) Of the cases, 30 (62.5%) were referred by private dental clinics. 3) Histopathologically, 37 cases (77.1%) were diagnosed to suffer from squamous cell carcinomas, 4 cases (8.3%) with malignant tumors in the salivary glands, 3 cases (6.3%) with malignant lymphomas, 2 cases (4.2%) with malignant melanomas, and 2 cases (4.2%) with metastatic tumors from other regions. 4) In 43 cases of primary malignant tumors, the most commonly affected site was the tongue (32.6%) followed by the lower gingiva (23.3%), upper gingiva (11.6%), floor of the mouth (11.6%), and mucosa of the cheeks (7.0%) and others (13.9%). 5) By the UICC (1987) stage grouping, 63.1% of 38 cases of primary carcinomas were clinically in the advanced stages III and IV. 6) In 36 primary oral cacinomas, 21 cases were treated by chemotherapy (C) + surgery (S), 8 cases by surgery alone, 1 case by irradiation (R) + surgery, 1 case by (C+S+R), and 5 cases by chemotherapy alone. 7) The 5-year cumulative survival rate was 55.2% in the 36 primary carcinoma cases

<臨床>ヘリカル3次元CTが有効であった3例

The present study showed the usefulness of three-dimensional helical CT images of the oral and maxillofacial region of three patients. The images provided a stereoscopic global view of the lesions and offered a good understanding of the material that can be used as a common basis for establishing a diagnosis or devising a treatment. We therefore believe that three-dimensional CT is useful in examinations of diseases in the oral and maxillofacial region

<臨床>側頚嚢胞の2例

There are many theories regarding the origin of the lateral cervical cyst, among them two main theories are mentioned. One is that the cyst arises from the embryonic branchial cleft and the other is that it originates from salivary gland epithelium enclosed in the embryonic lymphnodes. The investigators who support the former theory refer to it as the branchial cyst while the workers who support the latter refer to it as the lymphoepitherial cyst. The typical histologic feature is that the inner wall is covered with squamous epithelium and that lymphoid tissue is embedded in the outer wall. This cyst is located on the lateral side of the neck, hence it is called the lateral cervical cyst. Recently we have encountered two cases of this cyst, hence the outline of the cases will be given. CASE 1 : An 18-year-old female noticed a painless swelling on the right side of her neck two months hence. The swelling slowly increased in size and eventually she came to our clinic. Except for an egg-like diffuse swelling that fluctuated to palpation, her condition was aggravated. 15ml of yellowish liquid solution was aspirated by puncture probatoria and the cyst was diagnosed as a lateral cervical cyst. As a result the cyst was surgically removed. This case was diagnosed as a lateral cervical cyst, "BaileyI type," by operative and post operative pathological findings. CASE 2 : A 15-year-old female child noticed two walnut-like swellings on the right side of her upper neck about six months before coming to our clinic and was immediate referred to a surgeon. At surgery one cyst was removed. The cyst was diagnosed as non-mallignant. After surgery the remaining cyst grew in size and dimension. The swelling was 50mm in diameter on the center right side of the angulus mandiblae. At the first we considered the swelling as tuberculous lymphadenitis but after further examination we diagnosed the case as lateral cervical cyst and thus removed it by surgical methods. The cyst was diagnosed as a lateral cervical cyst, "Bailey II type" by operative and pathological findings