The epidemiological research of congenital Cytomegalovirus infection

背景人巨细胞病毒（HumanCytomegalovirus，HCMV）感染全球普遍，是新生儿先天性感染最常见且被严重忽视的病原体之一，也是造成儿童感音神经性听力损伤（Sensorineuralhearingloss，SNHL）和神经发育迟缓最主要的原因，是仅次于脑瘫的第二大导致严重畸形的原因。HCMV感染主要发生于婴幼儿时期，感染后终身携带，在机体免疫力下降或妊娠时期，易出现CMV再发感染（recurrentinfection）（包括潜伏病毒再激活（reactivation）和重叠感染新毒株（reinfection））。我国属于CMV高流行区，育龄女性CMV的血清流行率高于95%。近年来多项研...Background Human Cytomegalovirus (HCMV) infection is one of the most common congenital infections in the whole world. It is also the leading cause of the sensorineural hearing loss (SNHL) and the nerve growth retardation and the second common serious deformity ranked only lower to the cerebral palsy. HCMV infection occurs mainly in infants and young children. Due to reactivation of latent virus, r...学位：医学硕士院系专业：公共卫生学院_流行病与卫生统计学学号：3262014115055

車前子および蔓荊子からの抗アロディニア作用を持つイリドイドに関する研究

富山大学・富医薬博甲第347号・喻 欢欢・2020/09/28・★論文非公開★富山大

新生儿先天性巨细胞病毒感染的研究进展

巨细胞病毒(CMV)是全球最常见、危害最大且严重被忽视的新生儿先天性感染病原体,是新生儿中枢神经性耳聋和神经发育迟缓最主要的原因,全球新生儿先天性CMV感染的流行率总体为0.2%～2%[1]。新生儿发生先天性CMV感染后,约有15%～20%将出现永久性的生理缺陷,给社会带来较大的疾病负担。本文对先天性CMV感染的病原学、流行现状、临床表现、疾病负担和防治措施进行综合概述,旨在提高对新生儿先天性CMV感染的社会关注度。先天性CMV感染是指母亲在妊娠期内通过胎盘或脐血将病毒传给胎儿而导致的CMV感染[2-3],是宫内胎儿最常见的病毒感染,可导致新生儿中枢神经性耳聋和神经发育迟缓,甚至死亡。然而,过去先天性国家自然科学基金(81472015,31670927

河南省新密市不良妊娠结局的分布和危险因素分析

目的了解河南省新密市孕产妇不良妊娠结局的发生现状,并探究其影响因素。方法收集2015年1月-2017年4月在河南省新密市妇幼保健院进行孕检的孕早期孕妇3 124名,收集其人口学特征、既往妊娠史和本次妊娠情况,并随访其妊娠结局,分析不良妊娠结局发生率及其影响因素。结果不良妊娠结局的发生率为14.82%,不良妊娠结局排名前3位:巨大儿(8.19%)、早产(4.36%)和低出生体质量儿(2.67%)。有宫外孕史(OR=2.70,95%CI:1.16~6.29)、体质量指数(BMI)≥24 kg/m~2(OR=1.50,95%CI:1.21~1.88)和居住地为城市(OR=1.27,95%CI:1.03~1.56)是不良妊娠结局的危险因素。结论河南省新密市孕产妇不良妊娠结局的发生率处于较高水平,有宫外孕史、BMI≥24 kg/m~2和居住地为城市增加了不良妊娠结局的发生风险,需加强对该人群的孕前保健教育,以降低不良妊娠结局的发生率,改善母婴健康状况。中国博士后科学基金资助项目(2016M592093

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies