EB病毒潜伏膜蛋白1介导c-Jun/Jun B异源二聚体对cyclin D1的调节

研究发现LMP1可介导c-Jun/JunB活性异源二聚体的形成,在此基础上,利用建立的Tet-on系统调控LMP1表达的细胞系,采用间接免疫荧光法联合激光共聚焦荧光显徽镜技术、Westernblot方法、荧光素酶活性检测、Super-EMSA方法和流式细胞术,探讨LMP1介导c-Jun/JunB异源二聚体对cyclinD1的调节功能.结果表明,LMP1介导的c-Jun/JunB异源二聚体可上调cyclinD1启动子活性及其表达,并影响细胞周期的行进.国家重点基础研究发展规划(973计划)(批准号:G1998051201) 国家自然科学基金(批准号:30300403,30100005,30000087) 国家杰出青年科学基金(批准号:39525022)资助项

Expertadvice on the diagnosis and intervention of Chinese developmental dyslexia

发展性阅读障碍是一种以儿童阅读能力显著落后于年龄和智力应有水平为主的障碍，属于具有遗传基础的神经发育性障碍。目前国内对发展性阅读障碍的评估、诊断与干预多出现在科研场合，临床诊疗和教育性质的应用明显不足。专家意见采用专家书面反馈意见和视频会议讨论的形式，以发展性阅读障碍的病因学基础为指导，对发展性阅读障碍的临床表现、诊断流程及干预原则等形成统一意见，旨在为相关专业领域医师和康复专业人员提供参考和帮助，亦为开展对发展性阅读障碍的教育性干预活动提供参考。</p

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies