新PCI生物测量仪的重复性、再现性和一致性

目的评估基于部分相干干涉测量原理的新型眼生物测量仪Myopia Master用于测量眼轴、角膜曲率的重复性和再现性，比较其与IOL Master 500的一致性。方法同一名操作者随机先后顺序使用新型眼球生物测量仪Myopia Master和IOL Master 500采集屈光不正儿童右眼数据，以评估两仪器间一致性。其中部分儿童接受了Myopia Master重复性、再现性评估。数据包括眼轴（AL）、平坦角膜曲率（Kf）、陡峭角膜曲率（Ks）、平均角膜曲率（Km）、J0、J45。结果136人纳入一致性研究，其中58人纳入重复性和再现性研究。Myopia Master在AL测量中显示出高重复性、再现性（重复性Sw=0.02 mm， ICC=0.999；再现性Sw=0.04 mm， ICC=0.998），在角膜曲率测量显示中等的重复性［Sw范围：（0.04~0.12） D，ICC：（0.861~0.991）］和再现性［Sw范围：（0.06~0.20）D，ICC范围：（0.835~0.992）］。Myopia Master与IOL Master 500测量平均差异为AL（-0.01±0.04）mm、Kf（-0.09±0.15）D、Ks（-0.47±0.40）D、Km（-0.28±0.23）D、 J0（0.18±0.20）D和J45（-0.01±0.12）D。结论在儿童近视筛查中AL和角膜曲率测量中显示出高重复性和再现性，但临床上AL和角膜曲率在Myopia Master和IOL Master 500之间不可互换使用

多光谱屈光地形图在低度屈光不正儿童中的可重复性和一致性

目的评估睫状肌麻痹下多光谱屈光地形图（MRT） 在儿童视网膜屈光测量的可重复性和一致性。方法纳入8～10岁的学龄儿童，睫状肌麻痹后进行客观验光和眼轴长度测量；由同一检查者采用MRT重复进行两次视网膜屈光测量。视网膜屈光度和相对屈光度用视网膜偏差值（RDV）和相对视网膜偏差值（RRDV）表示。采用秩和检验，组内相关系数（ICC）和95%一致性极限（LoA）比较测量间的重复性和一致性。结果本研究共纳入146名儿童，平均年龄（9.22±0.61）岁。MRT与自动验光仪中央测量重复性ICC=0.94 （95%CI= ［0.92， 0.96］）；周边视网膜偏差值（RDV）从中央到周边各区域重复性良好，最小ICC=0.93 （95%CI= ［0.91， 0.95］），测量差异均无统计学意义（所有P＞0.05）。相对视网膜偏差值（RRDV）在中央30°内可重复性下降，最小ICC=0.37 （95%CI= ［0.12， 0.54］），30°以外可重复性有所提高，最小ICC=0.87 （95%CI= ［0.81， 0.90］）。RRDV所有参数连续两次测量结果差异均没有统计学意义（所有P>0.05）。结论在低度屈光不正的学龄儿童中，采用MRT测量视网膜周边屈光在同一检查者连续两次测量值具有极佳的可重复性，中央屈光与客观电脑验光仪有良好且稳定的一致性

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies

Prediction of Energy Resolution in the JUNO Experiment

International audienceThis paper presents the energy resolution study in the JUNO experiment, incorporating the latest knowledge acquired during the detector construction phase. The determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 MeV. To achieve this ambitious goal, significant efforts have been undertaken in the design and production of the key components of the JUNO detector. Various factors affecting the detection of inverse beta decay signals have an impact on the energy resolution, extending beyond the statistical fluctuations of the detected number of photons, such as the properties of liquid scintillator, performance of photomultiplier tubes, and the energy reconstruction algorithm. To account for these effects, a full JUNO simulation and reconstruction approach is employed. This enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy resolution. The study reveals an energy resolution of 2.95% at 1 MeV. Furthermore, the study assesses the contribution of major effects to the overall energy resolution budget. This analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data taking. Moreover, it provides a guideline in comprehending the energy resolution characteristics of liquid scintillator-based detectors