85 research outputs found

    Preliminary analysis on characteristics of water and sediment movement and environmental disasters changes in the Three Gorges reservoir area

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    三峡水库自2003年蓄水以来,积累了大量实际观测资料,为研究库区水沙运动特性及环境问题提供了有利条件.本文基于水库实际运用情况,对水库蓄水后的洪水波传播、悬移质泥沙运动、库区富营养化以及库岸滑坡灾害等的主要变化进行了初步分析,表明三峡水库蓄水运用后,这些方面发生了较大的改变,并呈现出新的特点,对三峡工程的长期运行有一定影响,其中反映的重要问题值得深入研究,并在今后的工程运用中应给予足够的重视.同时分析结果也为今后这些问题的研究提出了一些探讨性的方向和途径

    Construction and Analysis of Country - leading Cooperation Network in International Cooperation

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    探讨国际合作中国家主导的合作研究网络的构建与分析方法,将以国家为主导的研究意为文章第一作者或通讯作者的国籍是该国。以低维碳材料领域为例,使用Pajek分别绘制中国主导及其他国家主导、中国作为合作者的国际合作网络,并进一步以中、美合作为例,分析不同国家主导的合作内容差异。构建的国家主导的合作网络是消除了其它国家间合作关系的星型网络,更能突出中心国家主导作用下与其他国家的合作情况,有利于国际比较分析。</p

    浅谈UCLA医学教育与医学生素质培养——美国加州大学UCLA访学体会

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    医学是研究于人且服务于人的学科。出于对生命的尊重,医学生除应具备扎实的医学基础知识和临床技能外,加强素质教育显得尤为重要。UCLA David Geffen医学院注重医学生综合素质培养,致力于培养“医者”而非“医匠”。其医学整合课程有效地将基础、临床和社会医学内容结合,不仅提高了学生专业水平,而且加强了医学生素质培养。另外,贯穿模块学习的PBL教学法也在医学生素质培养中起关键性作用。2015年厦门大学教学改革项目资助;国家留学基金资助(201606315055)

    Research on Benefit Assessment of Ecological Compensation for Collective Non-commercial Forest in Natural Forest Protection Regions of Western China——Taking Yulong County in Yunnan, Xiuwen County in Guizhou and Jingbian County in Shanxi as Examples

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    文章从经济效益、社会效益、生态效益3个方面构建西部天保工程区集体公益林生态补偿效益评价指标体系,运用层次分析法的基本原理,对综合评价模型中的距离函数模型及指标量化方法进行分析。并结合西部天保工程区集体公益林生态补偿效益评价特点,构建和确定各层次判断矩阵及各指标权重。同时依据综合距离值的计算方法,说明判断集体公益林生态补偿效益高低的标准。以云南省玉龙县、贵州省修文县、陕西省靖边县为例,采用层次分析法对集体公益林生态补偿效益进行评价。评价结果显示:玉龙县、靖边县集体公益林生态补偿效益处于较高水平,修文县集体公益林生态补偿效益处于一般水平。针对存在的问题,提出提高案例县集体公益林生态补偿效益的建议。From the 3 aspects of economic benefits, social benefits and ecological benefits, the indicator system is for evaluating benefits of ecological compensation for the collective non-commercial forest in natural forest protection regions of western China. It analyzed the Distance Function Model and Indicator Quantitative Method by Analytic Hierarchy Process principle. Combining the characteristics of non-commercial forest ecological compensation forest benefit evaluation, it built judgment matrix of each level and determined the weight of each indicator. On the basis of calculating comprehensive distance value, it illustrated the standard to judge the benefits of ecological compensation for collective non-commercial forest. Taking Yulong County in Yunnan, Xiuwen County in Guizhou and Jingbian County in Shaanxi as examples, it adopted Analytic Hierarchy Process(AHP) principle to evaluate the benefits of ecological compensation for collective non-commercial forest. The evaluation results show that the benefits of ecological compensation for collective non- commercial forest in Yulong County and Jingbian County are at higher levels, but that in Xiuwen County is in the general level. Finally, it put forward some suggestions for improving the benefits of ecological compensation for collective non-commercial forest in case-counties based on their existing problems.国家自然科学基金资助项目“西部集体林区后天保工程时期的生态补偿机制研究”(编号:71273215)致谢:云南省玉龙县、贵州省修文县、陕西省靖边县林业局提供资料并给予帮助,在此表示感谢

    Association of a single nucleotide polymorphism in 8q24 rs1530300 and nonsyndromic cleft lip with or without cleft palate in Guangdong

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    目的:探讨8Q24 rS1530300单核苷酸多态性(SnP)与广东籍汉族人群非综合征性唇腭裂(nSCl/P)的相关性。方法:收集广东籍nSCl/P患儿168名及健康对照者127名的外周血,提取基因组dnA,应用高分辨率熔解曲线(HrM)技术检测rS1530300位点基因多态性,采用卡方检验进行病例组及其父母与正常对照组基因型、等位基因频率的比较分析和传递不平衡(TdT)分析。结果:成功建立8Q24 rS1530300位点基因多态性检测方法。病例组及正常对照组8Q24 rS1530300位点基因型频率分布均符合HArdyWEInbErg平衡。病例组及其父母的rS1530300位点基因型和等位基因的分布频率与正常对照组比较差异均无统计学意义(P均>0.05),等位基因也不存在传递不平衡(P>0.05)。结论:8Q24 rS1530300位点多态性与中国广东人群nSCl/P无明显相关性。OBJECTIVE: To explore the association between nonsyndromic cleft lip with or without cleft palate(NSCL/P) and genetic polymorphism of 8q24 rs1530300 in Chinese Han population located in Guangdong province.METHODS:Blood samples from 168 NSCL/P patients and 127 unrelated healthy individuals of the Chinese Guangdong population were collected.DNA was extracted and high resolution melting(HRM) was used to identify single nucleotide polymorphism of rs 1530300 in all samples.Chi square test was used to analyze the genotype and allele distribution between case group,father group,mother group and control group.Transmission-disequilibrium test was also carried out.RESULTS:The method for genotyping 8q24 rs1530300 was set up.The genotypic distribution of rs1530300 in case and control group did not deviate from the Hardy-Weinberg equilibrium.There were no significant differences in the frequency distributions of both genotypes and alleles when case group,or father group,or mother group was compared with control group at the rs1530300(P>0.05).We found no evidence of allele transmission-disequilibrium at rs1530300 in cleft caseparent trios(P>0.05).CONCLUSION:In our study,the genetic polymorphism of 8q24 rs1530300 was not associated with the development of NSCL/P in Chinese Han population located in Guangdong province.“重生行动-全国贫困家庭唇腭裂儿童手术康复计划”项

    藏药镰形棘豆的化学成分、药理作用及毒理学研究进展

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    目的:为进一步研究和开发利用藏药镰形棘豆提供参考。方法:以"镰形棘豆""莪达夏""化学成分""药理作用""毒理学""Oxytropis""Oxytropis falcata""Oxytropis falcata Bunge""Chemical constituents""Chemical composition""Pharmacologic actions""Toxicology"等为关键词,组合查询2010年1月-2016年2月在Pub Med、中国知网、万方、维普等数据库中的相关文献,对镰形棘豆的化学成分、药理作用、毒理学研究及临床应用进行综述。结果与结论:共检索到相关文献81篇,其中有效文献46篇。目前从镰形棘豆中分离鉴定的化学成分主要包括黄酮类、生物碱类、甾体及萜类等化合物,其具有抗炎镇痛、抗脓毒症、抗氧化、防紫外线损伤、抗缺血缺氧性损伤、抗肿瘤、免疫调节、抗纤维化、促凝止血、抑菌、止咳祛痰等广泛的药理作用;毒性研究报道并不多见;镰形棘豆除在藏医中常被用来治疗疫疠、麻风、感冒、便血、骨伤、刀伤等之外,现已有一些以镰形棘豆为主要组成的上市药品和医院制剂应用于临床。今后应加强其药理、药效、作用机制和毒理学研究。原南京军区医学科技创新项目(No.14MS085

    生物型纳米根管封闭剂的生物学性能研究

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    目的:对磷酸钙骨水泥为原料制备的生物型纳米根管封闭剂进行体外生物学性能研究,为其临床应用提供依据。方法:致敏性实验:依照GB/T16886.10-2005和GB/T16886.12-2005技术标准测定;细胞毒性实验:依照GB/T16886.5-2003技术标准,采用琼脂扩散法测定;鼠伤寒沙门氏杆菌回复突变试验(Ames试验):依照YY/T0127.10-2001技术标准测定。结果:生物型纳米根管封闭剂无致敏性,不导致染色体畸变,具有轻度细胞毒性。结论:生物型纳米根管封闭剂具有良好的生物学性能

    材料科学十年:中国与世界——基于2004-2013年WoS论文的文献计量分析

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    该文以2004-2013年间中国与世界材料科学的WoS论文为样本,对论文的产出规模、学术影响力、高被引论文表现、国际合作、分支学科领域布局等相关指标进行了文献计量分析,旨在了解中国与世界材料科学的发展态势,比较中国与世界相关国家的研究实力,分析中国材料科学领域的优势与不足,为制定材料科学发展战略和学科政策提供参考。</p

    Expression of the coat protein gene of IHHNV in shrimp in Pichia Pastoris

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    对虾传染性皮下及造血组织坏死病毒是“须向OIE申报的甲壳动物重要疾病“之一。将该病毒主要结构蛋白基因克隆至毕赤酵母穿梭表达质粒PPIC9k,构建重组表达载体(命名为PPIC9k-IV),限制性内切酶bglⅡ对其进行酶切线性化,采用电穿孔法转化到毕赤酵母gS115宿主菌。采用PCr方法分析和g418筛选来鉴定重组的毕赤酵母,诱导表达的产物分别进行ElISA分析或WESTErn blOT免疫印迹鉴定,分泌表达产物分子量大小为40ku左右,原核表达时制备的兔抗对虾传染性皮下及造血组织坏死病毒衣壳蛋白的血清可与真核表达的目的蛋白发生特异性反应。The infectious hypodermal & haematopoietic necrosis virus is one of the main diseases of the penaeid shrimp.The gene of coat protein of IHHNV was constructed into Pichia Pastoris secretory expression vectors pPIC9K,named pPIC9K-IV.The recombinant plasmid pPIC9K-IV was linearized with BglⅡ,and then was transformed into Pichia Pastoris GS115 by electroporation.After PCR analysis and G418 screening,the pPIC9KIV recombinant was expressed with 0.8%(V/V) methanol.The expression product was confirmed by Western blot and ELISA analysis.The results showed that the coat protein was successfully expressed,its product was about 40ku,and could recognized specifically by rabbit polyclonal anti-serum.国家质检总局科技基金资助项目(2006IK015
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