The role and mechanism of arsenic trioxide in Parkinson's disease model mice

帕金森病（Parkinson’sdisease，PD）是常见的神经系统退行性疾病，其病因及发病机制不明。流行病学调查表明神经炎症是帕金森病发病的促进因素，而且近年来研究提示辅助性T（Thelper，Th）17细胞在外周和中枢诱导的炎症反应促进了PD的发生，而对Th17细胞有拮抗作用的调节性T(regulatoryT，Treg)细胞的抗炎作用可以对PD发挥神经保护作用。已有发现雷帕霉素对PD有缓解治疗作用，但机制不明。本实验选用免疫抑制剂三氧化二砷对PD模型小鼠Th17/Treg平衡进行针对性干预治疗，同时对比雷帕霉素的治疗效果，探索三氧化二砷对PD的治疗作用和机制。我们发现三氧化二砷改善了MP...Parkinson's disease (PD) is a common degenerative disease of nervous system, and its etiology and pathogenesis has not yet been fully clarified. Epidemiological investigation has showed that nerve inflammation can promote the development of Parkinson disease. Recent studies have indicated that T helper (Th) 17 cells promote the occurrence of PD via enhancing the inflammatory response in the periph...学位：医学硕士院系专业：医学院_神经病学学号：2452014115351

Tourist temporal-spatial behavior and attractions selection influencing factors——A case study of Gulangyu

旅游业已经成为世界经济发展最快速的行业之一，每年激增的旅游人次是一个显著信号，预示着旅游市场的强大需求。在此背景和人本主义思潮下，旅游行为逐渐受到了国内外学者的关注，旅游行为大致包括旅游决策行为、旅游动机、旅游消费和时空行为等几个方面。其中旅游者时空行为研究一方面可以探求旅游业供需平衡的发展规律，为旅游产品设计及市场开发提供科学依据，另一方面旅游者时空行为的分析结果可以直接为旅游目的地的开发、规划和管理营销等提供有效参考，对于景区发展具有重要的意义。同时以往关于旅游者时空行为的研究往往只侧重描述性分析，对于时空行为特征的内在原因缺少进一步探索。本文以鼓浪屿旅游者时空行为特征为切入点，采用空间分...Tourism has become one of the world's fastest growing economic sector, the annual surge in tourist trips is a strong signal of the market, indicating strong demand for the tourism market. Against this background and the humanistic ideas, travel behavior gradually been the concern of many scholars. Travel behavior generally includes aspects of tourism decision-making behavior, tourism motivation, t...学位：工程硕士院系专业：建筑与土木工程学院_城市与区域规划学号：3082013115176

Reseach of Smartphone Remote Forensics System Based on Symbian OS

随着通讯技术的高速发展，智能手机已成为当下各大手机厂商必争之地，这 也推动了智能手机的普及。然而伴随着智能手机功能的不断完善和加强，利用手 机进行诈骗，诽谤和伪造等犯罪活动也屡见不鲜。而手机取证正是打击这类犯罪 活动的一个有效手段。本文正是基于此研究并设计了智能手机远程取证系统。 首先本文研究了手机取证的相关背景，阐述了国内外研究现状和亟待解决的 难题，总结了未来手机取证的发展趋势，并接着概述了智能手机和SymbianOS 相关基础知识，为本文后续的技术研究打下了坚实的理论基础。然后本文提出了 系统的总体目标，设计了系统的总体结构，并深入研究了系统各功能模块。这些 模块包括信息...With the development of communication technologies,smart phone has became the moment which all major mobile phone manufacturers contested. It is also contributed to the popularity of smartphone. However, along with the improvement of smart phone functions, the use of mobile phones for fraud, libel, forgery and other criminal activities are not uncommon. The mobile forensics is an effective means t...学位：工学硕士院系专业：信息科学与技术学院自动化系_控制理论与控制工程学号：2322008115335

Protective Effect of Atractylodes lancea on Oxidative Injury of H9c2 Myocardial Cells

目的茅苍术水煎液和它的含药血清对H9c2该细胞的保护效果的研究。方法采用双氧水制造H9c2大鼠心肌细胞的氧化损伤模型,以Vc为阳性对照,通过对受损心肌细胞形态学观测、SOD活力检测及细胞相对凋亡情况的检测,测定茅苍术水煎液和它的含药血清对H9c2细胞的保护效果。结果不同浓度的茅苍术水煎液均使细胞生长状态得以改善,外部形态明显好转。高剂量组细胞生长较好,中剂量组次之,低剂量组较差;茅苍术水煎液组LDH释放量和MDA含量明显低于Vc对照组,SOD活力明显高于损伤组;细胞的相对存活率随着茅苍术水提液的浓度升高而明显增大,分别为72.37%、66.19%、55.44%,低剂量组的茅苍术水提液对H2O2损伤的H9c2心肌细胞的保护作用不明显。结论茅苍术水提液的保护作用机制与增强细胞抗氧化能力、减少自由基和脂质过氧化物导致的细胞膜损伤有关。Objective To investigate the protective activity of Atractylodes lancea decoction and its medicated serum on H9c2 cell.Methods The H2O2-based oxidative injury model was established by cultivating rat cardiomyocytes of H9c2 in vitro,and the antioxidant activity was evaluated by cell morphology,apoptosis and the effect on SOD.Results The growth state of the cells could be improved by the decoction of the different concentrations of Atractylodes lancea,and the external form was significantly improved.The high dose group cells grew well,and the low dose group was poor.The release amount of LDH and MDA of Atractylodes lancea group were significantly lower than those of the Vc control group,SOD activity was significantly higher than that in the injury group,the relative survival rate of cells with the concentration of aqueous extract of Atractylodes lancea obviously increased,it was 72.37%,66.19% and 55.44%,respectively.The protective effect of the aqueous extract of the low dose group on the H2O2 damage of H9c2 myocardial cells was not significant.Conclusion The mechanism of protective effect of water extract of Atractylodes lancea liquid is related to enhancing cellular antioxidant capacity and cell membrane damage caused by reducing free radicals and lipid peroxide

Application of membrane technology to classify nano-meter Titanium dioxide and Ferric oxide

纳米材料是20世纪80年代末期兴起的，是一类具有重要理论价值和广阔应用前景的新型功能材料,被誉为21世纪最有前途的材料。由于其具有粒径小、比表面积大的特点，使其具有奇异的特性，如表面效应、小尺寸效应和宏观量子隧道效应。在本文中我们主要研究膜分离技术在分级分离纳米颗粒的应用研究，获取单分散性的纳米颗粒，主要工作内容包括以下四个方面：在本文的第一章，主要对论文中涉及到的两种纳米材料的制备和应用的情况进行了概括性的介绍。纳米TiO2和纳米Fe2O3作为纳米新材料中的一类重要氧化物，由于其化学性质稳定，催化活性高，使它们在纳米陶瓷、塑料制品、涂料、催化剂以及医学和生物工程等方面有着广泛的应用价值和前景...Nano materials arised from 1980s, as a new functional material, which has important value in theory and broad prospect in application, and is regarded as the most promising material in the 21st century. For their small particle size, high special surface, nano materials have very fantastic characteristics, such as surface effects, small dimension effects and the macroscopic quantum tunnel effects....学位：理学硕士院系专业：化学化工学院材料科学与工程系_高分子化学与物理学号：20033600

On survey of time-space behavior based on GPS technique

简述了时空行为研究的主要内容,介绍了时空行为研究获取数据的方法,并从日常行为规律、旅游行为规律、数据挖掘与处理三个角度出发,对基于gPS技术的时空行为研究进展进行了分析,指出gPS将会是各个学科采集时空行为数据的最优选择。The paper indicates the contents for the time-space behavior,introduces the methods for the research on the data from the time-space behaviors,analyzes the research progress based on GPS technique from the daily behavior law,tourist behavior law,data digging and treatment,and points out GPS can be the optimal choice for collecting the data about the time-space behaviors

清代汉口商人会馆的建构及其类型

本文首先以汉口紫阳书院的建构过程为例,指出清代汉口的商人会馆从社会、历史和文化环境中获取组织模式的建构过程。各商人群体的同乡意识与地域文化特征与清代汉口的社会背景相互作用,不断产生新的象征符号和集体意义,从而塑造出新的、变化了的会馆组织形式。根据其内部权力运作、管理模式和外部谋求目标的不同,汉口的商人会馆可以划分为"礼俗性会馆组织"、"利益型会馆组织"、"行业型会馆组织"三种基本类型

Discussion on The Problems and Countermeasures of The Female Employment

女性占我国劳动力人口的半数，是人力资源中不可或缺的组成部分。女性就业是女性获得经济社会资源、提高社会地位、保持人格独立和尊严的重要途径之一，是社会财富的重要来源，也是衡量社会发展和社会进步的重要依据。但现实中女性就业却面临着很多问题，比如女性就业质量不高，女性劳动参与率下降明显，两性收入差距不断扩大，就业机会、职业待遇以及发展机会的不平等等。因此对女性就业问题的研究具有重要的理论和现实意义，是社会公平正义和文明进步的体现。本文主要采用了定性与定量分析相结合的研究方法，对女性就业存在的问题进行分析，并提出促进女性就业的政策建议。 全文共分为五个部分： 第一部分：是引导部分，主要阐述了女性就业...Half of the labor force population in China are women, an indispensable part of human resources.The female employment is one of the important ways to obtain economic and social resources, improve women's social status and maintain the independence of personality and dignity, an important source of social wealth and important basis of social development and social progress. But in reality, women's ...学位：管理学硕士院系专业：公共事务学院_社会保障学号：1392012115045

Modern Transformation of Local Opera and Construction of Regional Culture: A Study of Xiang Opera

本文试图探索晚清至1930年代“湘剧”在认知与实践层面上的建构过程。自清中叶以来，随着城市商业化进程的推进，地方戏曲演出兴盛起来，演出机制逐渐扩展。这一时期内，在地方精英的价值评估话语中，戏曲的角色在“声色”与“教化”两个范畴之间游移；这使得他们一方面将戏曲排除在正统的文化体系之外；另一方面习惯性地参与到地方戏曲的活动中。晚清至民国初期，在新兴的知识分子重构“文化”的过程中，戏曲被纳入“文化”的范畴；地方戏曲亦获得了文化上的地位，但尚未发展成为一个内部分化的艺术体系。1920年以来，闲吟曲社的票友群体确立了“湘剧”这一概念，地方戏曲被建构为地域传统与文化的表征，其艺术本质及特征逐渐得以凸显。1...The dissertation surveys the making of Xiang Opera from the late Qing period until the 1930s, when the regional society and culture underwent a process of modern transformation. In the middle and late Qing dynasty, local opera thrived in the expanding institutions and changing urban commercialization. During this period, the role of opera in the local elite discourse vacillated between vulgar ente...学位：历史学硕士院系专业：人文学院历史学系_专门史学号：1032006115010

Design and Implement of the Media Asset Information Management System

随着社会经济全球化和科学技术的迅猛发展，以及中国高等教育规模的不断扩张，作为社会信息化的重要组成部分，高等院校的信息化是我国现代教育改革的重要标志，也是促进我国教育改革全面发展的必然措施。 当前,大部分髙校有独立的信息技术服务部门和网络技术中心,负责校园办公网络、校园管理网络、图书馆资源管理平台等校园网软硬件设施的开发与维护。同时,经过了多年的发展，各高等学校也积累了大量的数字媒体信息资源,主要包括视频、音频以及图片等。这些资源包含由教学研究过程中和师生生活中产生的数字媒体数据资源，资源由于存储分散、缺乏统一管理、不便于共享和重复利用。所以，如果让这些重要的媒体信息资料充分发挥其应有的作用，...With the rapid development of economic globalization and social science and technology, and the continuous expansion of the scale of higher education China, as an important part of society informationization, institutes of higher education informatization is an important symbol of China's modern education reform, is also the inevitable measures to promote education reform of our country's full dev...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X201323007