虚脱療法の肺の結核病巣に及ぼす影響についての実験的研究 特に人工氣胸について

1) Five rabbits were injected with human tubercle bacilli directly into the lung being followed by subjecting to artificial pneumothorax therapy one month after the inoculation, and were examined clinically and pathologically for a period of five months, and were compared with non-treated controls.2) No marded difference was observed between the tuberculin reaktion, body weight or X-ray finding of the treated animals and those of the controls.3) However, the tuberculous changes of the lungs of the treated animals were less severe than those of the controls, and this revealed the marked tendency of healing, from the viewpoint of pathological histology.4) The histological findings indicated that no qualitative difference was observed between the healing process of the cases receiving artificial pneumotholax and that of the cases receiving chemotherapy, except for a marked proliferative endarteritis observed in the lungs of the former.In these cases, however, disappearance of tubercle bacilli in the tuberculous lesions was delayed as compared with that in the case of chemotherapy, and this may suggest that there is a difference in the effecting mechanism between the pneumothorax and those of the chemotherapy.5) It was considered that the healing processes were brought about by the effects upon the tissues of foci, but not by the direct effects upon the bacilli themselves

珒化学療法が結核アレルギー病変に及ぼす影響に関する実瞼的研究 第1篇 実験的再感染結核におけるSM治療の効果について

Human tubercle bacilli sensitized rabbits were super-infected with the same bacilli intravenously and were subjected to SM-therapy. The infected lungs were removed at certain intervals and examined histologically. 1) Tuberculous changes developed more intensively and earlier in the lungs of the rabbit super-infected with the bacilli than those in the lungs of the animals infected only once with the bacilli. In the super-infected and non-treated animals, the tubercle bacilli were disintegrated and reduced in their number mainly due to allergic reaction within a week after the reinoculation, while from. the 2nd week they began to propagate" markedly as soon as the animal fell into anergie state followed by cavity formation, one of the most severe manifestations of tuberculous changes of the lungs. From the 6th week on, the lesions became localized. This was considered as one of the healing processes of tuberculous lesions. 2) In the animals subjected to SM-treatment simultaneously with the super-infection, the same tissue lesions were observed as in the non-treated animals in the early stages, while the lesions rapidly became reduced in size and severity 2 weeks after the reinoculation without further propagation of the tubercle bacilli, and there after the tubercles were resorbed and disappeared

珒化學療法が結核アレルギー病變に及ぼす影響に關する実験的研究 第4篇 結核初感染における SM, PAS, INAH 治療実験

Rabbits were submitted to intravenous inoculation of the human tubercle bacilli and intramuscular injection of SM, PAS or INAH at the same time, and the lungs were examined histologically at certain intervals after the \u27infection\u27 and \u27treatment\u27. 1) In the lungs of the animals inoculated with tubercle bacilli alone, tuberculous lesions were first observed in the 3rd day and gradually grew in severity, showing numerous typical tubercles 4 weeks after the inoculation. Tubercle bacilli themselves also increased gradually. 2) In the animals submitted to bacilli infection and SM treatment, the tuberculous lesions in the lungs were similar to those appearing in the lungs of animals which were infected with the bacilli without SM treatment in the 3rd day after the inoculation, while the tubercles which were observed in the 4th week after the inoculation were atypical and cirrhotic. The tubercle bacilli themselves decreased gradually without increasing. 3) The lungs of the animals treated with PAS also showed similar tuberculous changes to those treated with SM, while thickening of alveolar walls, infiltration of multi-and mononucleated large cells into alveoles possibly are the histological characteristics of the former. Though the bacilli were found all animals a remarkable increasse was not to be observed. 4) The tuberculous changes of the lungs of the animals treated with INAH were similar to those treated with SM. 5) The above-mentioned results might indicate that no marked differences of effectiveness exists between SM and INAH but that the effectiveness of PAS were somewhat less than that of SM and INAH

珒化学療法が結核アレルギー病変に及ぼす影響に関する実験的研究 第3篇 一次性アレルギー (武田) における SM, INAH の治療実験

Rabbits were infected with 5 mg of human tubercle bacilli intravenously, followed by SM- and INAH-treatments from one month after the bacilli infection. The lungs were removed at certain intervals and histologically examined in the usual manner. 1) Control cases. Markedly developed tuberculous lesions were observed in the lungs one month after the bacilli infection, and thereafter intensified in severity accompanied with exsudative inflammation. Proliferation of the tubercle bacilli were detected in all cases. 2) Cases treated with SM. In the animals treated with SM, tuberculous lesions in the lungs were reduced in their severity in the 2nd week after the treatment, showing remarkable therapeutical effects of the medicament, with marked reduction of the bacilli count in the lesions. At the end of the 6th week after the treatment tuberculous lesions were hardly observed with a very small amount of tubercle bacilli. 3) Cases treated with INAH. In the animals treated with INAH, less therapeutic effects of the medicament were observed than in those treated with SM from histological view-points. However, tubercle bacilli themselves were reduced markedly from the 2nd week after the treatment and almost disappeared at the end of the 6th week, similar to those in the SM-treated animals

珒化学療法が結核アレルギー病変に及ぼす影響に関する実験的研究 第6篇 全篇の総括並びに考按

1) Different effectiveness among SM, PAS and INAH was observed upon tuberculous changes, which were experimentally produced in rabbits of normergic or allergic state. 2) In normergic state, SM and INAH were more effective than PAS, while the effectiveness of SM was more rapid and pronounced than those of INAH and PAS in both primary and secondary allergic states (TAKEDA). 3) From histological and bacteriological viewpoints, it was considered that the chemotherapeutics have no effect upon the antigen-antibody reaction, but upon the bacilli themselves which proliferated as results of anergization of tuberculous foci. 4) The pronounced bactericidal ability of SM caused the reduced lesions in the lungs of the animals treated with the agent, while INAH or PAS showed less effectiveness resulting delayed healing of the tuberculous lesions. 5) The above mentioned differences in effectiveness upon the tuberculous lesions in allergic state among these three chemotherapeutics were considered to be due to the fundamental differences among their acting mechanisms. 6) The histological findings of the experimentally induced tuberculous changes of the lungs of the animals treated with the chemotherapeutics which were described in this paper were similar to those as previously described by other authors. 7) The proliferation of connective tissues and the congestion or bleeding in the tuberculous foci, as characteristics of the histological features, were observed in the tuberculous lesions of the lungs of the animals treated with PAS or INAH

珒化學療法が結核アレルギー病変に及ぼす影響に関する実験的研究 第2篇 結核再感染における PAS, INAH治療実験

Rabbits sensitized with the human tubercle bacilli were reinfected with the same bacilli intravenously and were treated with PAS or INAH. The lungs were histologically examined at certain intervals using routine procedures. 1) In the lungs of the animals treated with PAS, miliary tubercles were found in the third to the 7th day after the inoculation, being similar to those in the lungs of the reinfected and non-treated animals. The tuberculous changes developed intensively with propagation of the bacilli for 2 weeks after the inoculation, while thereafter the healing processes as indicated by proliferation of connective tissues and collagenization of argyrophilic fibers, began to appear more rapidly than those in control animals. 2) In the animals treated with INAH, prominent hyperemia and bleeding were observed around the tubercles in the lungs on the 3rd day after the infection. For 2 weeks the tuberculous lesions were similar to those found in the lungs of PAS-treated animals in their severity. Thereafter the lesions began to reduce their severity with increased proliferation of blood capillaries, hyperemia and bleeding

珒化學療法が結核アレルギー病変に及ぼす影響に関する実験的研究 第5篇 化學療法施行後一定期間放置時における觀察

1) Marked tuberculous changes were observed in the lungs of rabbits inoculated with the human tubercle bacilli (Nakano strain) of 1/1000 mg, 1/100 mg or 10 mg, even in the 16th week after inoculation. 2) In the lungs of the animals treated with SM or INAH during the first 8 weeks, less tuberculous changes were observed than in these of the controls, at the end of 16th week after the bacilli inoculation. The effectiveness of INAH would be somewhat pronounced as compared with that of SM

A Report of Supporting project for a deaf Child and her Mother in Parent and Infant Program at a School for the deaf by Japanese Sign Language Signers

聴覚特別支援学校（以下，聾学校）において，親子を支援する取り組みを行った。この実践は，日本手話話者であるろう者講師ときこえる教師が，子どもの保護者と協同して取り組んだ。きこえる母親と聴覚障がいをもつ子どものコミュニケーションをより豊かにすることを目的とした実践を報告する。なお，本稿でのろう児・ろう者は，日本手話をつかうきこえない人を，聴者・聴保護者・聴教師は，聴覚障がいがない人を指す