珒化学療法が結核アレルギー病変に及ぼす影響に関する実験的研究 第3篇 一次性アレルギー (武田) における SM, INAH の治療実験

Abstract

Rabbits were infected with 5 mg of human tubercle bacilli intravenously, followed by SM- and INAH-treatments from one month after the bacilli infection. The lungs were removed at certain intervals and histologically examined in the usual manner. 1) Control cases. Markedly developed tuberculous lesions were observed in the lungs one month after the bacilli infection, and thereafter intensified in severity accompanied with exsudative inflammation. Proliferation of the tubercle bacilli were detected in all cases. 2) Cases treated with SM. In the animals treated with SM, tuberculous lesions in the lungs were reduced in their severity in the 2nd week after the treatment, showing remarkable therapeutical effects of the medicament, with marked reduction of the bacilli count in the lesions. At the end of the 6th week after the treatment tuberculous lesions were hardly observed with a very small amount of tubercle bacilli. 3) Cases treated with INAH. In the animals treated with INAH, less therapeutic effects of the medicament were observed than in those treated with SM from histological view-points. However, tubercle bacilli themselves were reduced markedly from the 2nd week after the treatment and almost disappeared at the end of the 6th week, similar to those in the SM-treated animals

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