Characteristics and clinical correlates of white matter changes in brain magnetic resonance of migraine females

Objective: White matter hyperintensities (WMHs) were often found in migraine patients. The aim of study was to characterize WMHs, assess their prevalence, determine relationship to clinical symptoms and homocysteine levels in migraine females. Methods: 69 women 38 with migraine without aura (MO), 31 with migraine with aura (MA) who underwent brain MRI with 1.5T scanner were enrolled. TheWMHsnumber, location and size in FLAIR sequence were evaluated. Migraine severity was measured by pain intensity, number of attacks per month and MIDAS scale. Results: WMHs were found in 39.1% females. There was no WMHs and migraine typecorrelation. The total WMHs number was higher in MO ( p = 0.027). Patients with WMHswere older ( p = 0.025), have higher BMI ( p = 0.042), suffered longer ( p = 0.001), more often had positive pregnancy history ( p = 0.010) and less frequent prodromal symptoms. The age of onset, migraine's severity and homocysteine did not correlate with WMHs. No effect of antimigraine medication and oral contraceptive pills (OCP) was found. Both in MO and MA groupsWMHswere located only supratentorially. In MO femalesWMHswere mainly located in one cerebral hemisphere ( p = 0.024) whereas in MA were found bilaterally. WMHs were most commonly located in the frontal lobes. In MOlesions were small ≤3 mmand present in almost all MO patients ( p = 0.027).Conclusion: WMHs are present in more than one third of migraine females, regardless of aura. WHMs are located supratentorially, subcortically and in the frontal lobes. Older age, longer disease's duration, obesity and positive history of pregnancy are main risk factors for WMHs. Symptomatology and migraine severity, hyperhomocysteinemia, OCP and antimigraine medications do not increase WMHs

Hybridization in contact zone between temperate European pine species

Hybridization studies are important to advance our understanding of the interspecific gene flow and its evolutionary consequences in closely related species. Hybridization and admixture patterns were assessed in a contact zone and reference populations of European pine species using sequence data from 26 nuclear genes and a species-diagnostic cpDNA marker. Reference populations formed three distinct genetic clusters comprising Pinus sylvestris, Pinus mugo/Pinus uliginosa, and Pinus uncinata. Evidence of population structure was found only in P. uliginosa. Based on phenotypic characteristics and molecular data, we identified five groups of individuals in the contact zone in Poland, comprising forms of the parental species and intermediates that were most probably the result of interspecific crosses. A combination of nuclear gene sequence data and a diagnostic organelle marker were used to show that hybridization is frequent in the contact zone and results in hybrid trees with distinct phenotypic identity. The influence of selection in maintaining hybrid phenotypes in environments unsuited to parental species was inferred from nucleotide polymorphism data. A lack of admixture in reference populations suggests that hybridization has not occurred during post-glacial migration and so the contact zone represents a distinct, active example of ongoing evolution. Pine populations in this zone will be a valuable system for studying the genetic basis of hybrid advantage in environmental conditions untypical of pure parental species

Relationship between intestinal microbiota and thyroid homeostasis

The human digestive tract is inhabited by hundreds of bacterial species, both aerobic and anaerobic, bacteriophages, viruses and fungi that collectively are referred to as intestinal microbiota. Microbiota has a significant impact on the production and maintenance of immunological, hormonal and metabolic homeostasis. Dysbiosis is present in inflammations, e.g. intestinal inflammation, autoimmune diseases, e.g. multiple sclerosis, type 1 diabetes, rheumatic diseases, metabolic disorders such as obesity or type 2 diabetes, and mental illness. Currently, numerous studies are underway on the effect of microbiota on thyroid autoimmune diseases. . It seems, that microbiota has a small, if any, effect on the metabolism of iodine and selenium - elements particularly responsible for thyroid homeostasis. However, the relationship between thyroid function and the gastrointestinal tract has been proven

Perioperative management. Nutrition in the perioperative period

The current patterns of perioperative management are subject to dynamic changes, questioning and modifying the previously used ones. In modern surgical practice, it is recommended to apply a comprehensive peri-operative care protocol to improve the results of ERAS (Enhanced Recover After Surgery) treatment. ERAS is a multidirectional path of perioperative care over a patient, used all over the world, developed by the international scientific society ERAS Society, initiated by the Danish surgeon Henrik Kehlet. This protocol aims to achieve the fastest possible recovery of the patient by minimizing metabolic stress caused by surgery, improving the healing process, reducing tissue swelling, reducing the number of postoperative complications, shortening the duration of hospitalization and reducing the cost of health care

The relationship between intestinal microbiota and polycystic ovary syndrome

Introduction: PCOS is a hyperandrogenic and low-pathogenic disease and patients suffering from PCOS have significantly lower intestinal microbiota variation in comparison with healthy individuals. Aim of the study:The aim of the work is to overview the literary production regarding reliance between intestinal microbiota and polycystic ovary syndrome. Conclusions: Results of the research show change in microbiome data amongst women suffering from polycystic ovary syndrome

Physical activity of pregnant women

Korabiusz Katarzyna, Wawryków Agata, Fabian-Danielewska Anna, Stecko Monika, Żukowska Magdalena, Janik Inga, Andrusewicz Wojciech, Torbé Andrzej. Physical activity of pregnant women. Journal of Education, Health and Sport. 2018;8(8):1026-1031. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1414249 http://ojs.ukw.edu.pl/index.php/johs/article/view/5965 https://pbn.nauka.gov.pl/sedno-webapp/works/876966 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.08.2018. Revised: 18.08.2018. Accepted: 31.08.2018. Physical activity of pregnant women mgr Katarzyna Korabiusz¹, mgr Agata Wawryków¹, lek. Anna Fabian- Danielewska2, mgr Monika Stecko¹, lek. Magdalena Żukowska2, mgr Inga Janik¹, lek. Wojciech Andrusewicz2, prof. dr hab. n. med. Andrzej Torbé3 ¹ Pomorski Uniwersytet Medyczny w Szczecinie, Studium Doktoranckie Wydziału Nauk o Zdrowiu, ul. Żołnierska 54, 71-210 Szczecin 2 Pomorski Uniwersytet Medyczny w Szczecinie, Studium Doktoranckie Wydziału Lekarskiego, ul. Żołnierska 54, 71-210 Szczecin 3 Pomorski Uniwersytet Medyczny w Szczecinie, Klinika Położnictwa i Ginekologii, ul. Powstańców Wlkp. 72, 70-111 Szczecin Dane autora korespondencyjnego: Katarzyna Korabiusz [email protected] Key words: physical activity, pregnancy. ABSTRACT Every pregnant woman should be aware that her every day health habits affect the child's health, but also her health during pregnancy, delivery and post-partum period. Physical activity plays an important role during pregnancy. It improves the overall physical condition and prevents many ailments of pregnancy. The most important aspect of taking physical activity during pregnancy is the right choice of exercise and regularity and appropriate technique. Due to many benefits of proper exercises during pregnancy, pregnant women should be encouraged and educated in this area

The application of orthopedic equipment in the form of orthoses in children suffering from cerebral palsy

Cerebral palsy is a broad term, including various, changing with age movement and postural disorders of cerebral origin [1]. Gait of children suffering from cerebral palsy is characterized by changeability. Observed gait abnormalities are caused by incorrect steering of movements of a child and they are the effects of brain damage and compensation mechanisms. The orthoses should be applied in children suffering from cerebral palsy to protect against deformations of lower limbs. An orthosis prevents the occurrence of articular contractures, probably as a result of inhibition of biomechanical changes in periarticular collagen caused by immobilization [9,10]. Selecting an appropriate orthosis is a key element of the process of treatment of diseases of musculoskeletal system. Orthosis should always be selected individually, depending on the needs and capabilities of a patient. The following orthoses can be distinguished: ankle joint orthoses, dynamic foot orthosis and complex orthoses stabilizing ankle joint, knee joint and hip joint. Selecting an appropriate orthopedic equipment is a very important aspect in complex rehabilitation of children suffering from cerebral palsy

Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes HSC and granulocytes to the blood

Granulocyte colony-stimulating factor (G-CSF) is used in clinical practice to mobilize cells from the bone marrow to the blood; however, it is not always effective. We show that cobalt protoporphyrin IX (CoPP) increases plasma concentrations of G-CSF, IL-6, and MCP-1 in mice, triggering the mobilization of granulocytes and hematopoietic stem and progenitor cells (HSPC). Compared with recombinant G-CSF, CoPP mobilizes higher number of HSPC and mature granulocytes. In contrast to G-CSF, CoPP does not increase the number of circulating T cells. Transplantation of CoPP-mobilized peripheral blood mononuclear cells (PBMC) results in higher chimerism and faster hematopoietic reconstitution than transplantation of PBMC mobilized by G-CSF. Although CoPP is used to activate Nrf2/HO-1 axis, the observed effects are Nrf2/HO- 1 independent. Concluding, CoPP increases expression of mobilization- related cytokines and has superior mobilizing efficiency compared with recombinant G-CSF. This observation could lead to the development of new strategies for the treatment of neutropenia and HSPC transplantation

Dysbiosis of the digestive tract after antibiotics treatment

A human organism is a great place for living a huge and very diverse microflora. The most colonized seems to be the digestive tract. The balance between the host organism and the microbiome is extremely important. One of the causes of homeostasis disorders may be treatment with antibiotics. During antibiotic therapy, the natural intestinal microbiota is depleted. As a consequence, the risk of uncontrolled development of Clostridium difficile is significantly increased. Intestinal infections due to this pathogenic rote are a serious health problem

Ionic conductivity, viscosity, and self-diffusion coefficients of novel imidazole salts for lithium-ion battery electrolytes

Lithium-ion battery performance and longevity depend critically on the conducting salt utilized in the electrolyte. With new avenues for multifunctional integration and optimization of functional properties, conducting salts beyond lithium hexafluorophosphate (LiPF$_6$) need to be studied. Herein we elucidate on viscosity, ionicity, anion self-diffusion and ionic conductivity through variation of the length of the perfluoroalkyl side chain present in the anions of the used lithium imidazole salts. Specifically, we study LiPF$_6$ in comparison with lithium 4,5-dicyano-2-(trifluoromethyl)imidazolide (LiTDI), lithium 4,5-dicyano-2-(pentafluoroethyl)imidazolide (LiPDI), and lithium 4,5-dicyano-2-(n-heptafluoropropyl)imidazolide (LiHDI). We find that the ion mobility of LiPF$_6$ depends the least on viscosity and its ionicity is the highest among the electrolytes investigated here. LiTDI shows the strongest correlation between ion mobility and viscosity and the lowest ionicity. LiPDI and LiHDI range between these two regarding their ionicity and the correlation of mobility with viscosity. The previously rarely studied anion self-diffusion coefficients exhibit a strong correlation with viscosity as it was to be expected. Differences between the LiTDI, LiPDI and LiHDI salts are minute