The human digestive tract is inhabited by hundreds of bacterial species, both aerobic and anaerobic, bacteriophages, viruses and fungi that collectively are referred to as intestinal microbiota. Microbiota has a significant impact on the production and maintenance of immunological, hormonal and metabolic homeostasis. Dysbiosis is present in inflammations, e.g. intestinal inflammation, autoimmune diseases, e.g. multiple sclerosis, type 1 diabetes, rheumatic diseases, metabolic disorders such as obesity or type 2 diabetes, and mental illness. Currently, numerous studies are underway on the effect of microbiota on thyroid autoimmune diseases. . It seems, that microbiota has a small, if any, effect on the metabolism of iodine and selenium - elements particularly responsible for thyroid homeostasis. However, the relationship between thyroid function and the gastrointestinal tract has been proven

Fabian-Danielewska, Anna

Korabiusz, Katarzyna

Stecko, Monika

Wawryków, Agata

Żukowska, Magdalena

Journal of Education Health and Sport

English

Fabian-Danielewska Anna, Wawryków Agata, Korabiusz Katarzyna, Stecko Monika, Żukowska Magdalena. Relationship between intestinal microbiota and thyroid homeostasis. Journal of Education, Health and Sport. 2019;9(4):375-379. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2639384

http://ojs.ukw.edu.pl/index.php/johs/article/view/6827

https://pbn.nauka.gov.pl/sedno-webapp/works/911077

 

 

 

 

 

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017).

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

 

© The Authors 2019;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.

(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

 

The authors declare that there is no conflict of interests regarding the publication of this paper.

 

Received: 28.03.2019. Revised: 30.03.2019. Accepted: 14.04.2019.

 

 

 

 

 

 

Relationship between intestinal microbiota

and thyroid homeostasis


 

Anna Fabian-Danielewska1, Agata Wawryków2, Katarzyna Korabiusz2,

Monika Stecko2, Magdalena Żukowska2


 

1 Pomorski Uniwersytet Medyczny w Szczecinie, Studium Doktoranckie Wydziału Lekarskiego

2 Pomorski Uniwersytet Medyczny w Szczecinie, Studium Doktoranckie Wydziału Nauk o Zdrowiu


 


 

lek. Anna Fabian-Danielewska1, mgr Agata Wawryków2, mgr Katarzyna Korabiusz2,

mgr Monika Stecko2, lek. Magdalena Żukowska2


 


 


 


 

Key words: microbiota, thyroid


 


 

Summary

The human digestive tract is inhabited by hundreds of bacterial species, both aerobic and anaerobic, bacteriophages, viruses and fungi that collectively are referred to as intestinal microbiota. Microbiota has a significant impact on the production and maintenance of immunological, hormonal and metabolic homeostasis. Dysbiosis is present in inflammations, e.g. intestinal inflammation, autoimmune diseases, e.g. multiple sclerosis, type 1 diabetes, rheumatic diseases, metabolic disorders such as obesity or type 2 diabetes, and mental illness. Currently, numerous studies are underway on the effect of microbiota on thyroid autoimmune diseases. . It seems, that microbiota has a small, if any, effect on the metabolism of iodine and selenium - elements particularly responsible for thyroid homeostasis. However, the relationship between thyroid function and the gastrointestinal tract has been proven

NEUROSURGERY ENTHUSIASTIC WOMEN SOCIETY

Relationship between intestinal microbiota and thyroid homeostasis

Akademicka Platforma Czasopism

Fabian-Danielewska Anna, Wawryków Agata, Korabiusz Katarzyna, Stecko Monika, Żukowska Magdalena. Relationship betweenintestinal microbiota and thyroid homeostasis.  Journal of Education, Health and Sport. 2019;9(4):375-379. eISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.2639384http://ojs.ukw.edu.pl/index.php/johs/article/view/6827The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017).1223 Journal of Education, Health and Sport eISSN 2391-8306 7© The Authors 2019;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 28.03.2019. Revised: 30.03.2019. Accepted: 14.04.2019.Relationship between intestinal microbiotaand thyroid homeostasisAnna Fabian-Danielewska1, Agata Wawryków2, Katarzyna Korabiusz2,Monika Stecko2, Magdalena Żukowska21 Pomorski Uniwersytet Medyczny w Szczecinie, Studium Doktoranckie Wydziału Lekarskiego2  Pomorski  Uniwersytet  Medyczny  w Szczecinie,  Studium Doktoranckie  Wydziału  Nauk  oZdrowiulek. Anna Fabian-Danielewska1, mgr Agata Wawryków2, mgr Katarzyna Korabiusz2,mgr Monika Stecko2, lek. Magdalena Żukowska2Key words: microbiota, thyroid375SummaryThe human digestive tract is inhabited by hundreds of bacterial species, both aerobic andanaerobic, bacteriophages, viruses and fungi that collectively are referred to as intestinalmicrobiota.  Microbiota  has  a  significant  impact  on  the  production  and  maintenance  ofimmunological, hormonal and metabolic homeostasis. Dysbiosis is present in inflammations,e.g. intestinal inflammation, autoimmune diseases, e.g. multiple sclerosis, type 1 diabetes,rheumatic diseases,  metabolic  disorders  such as  obesity  or  type 2  diabetes,  and mentalillness.  Currently,  numerous studies are underway on the effect of microbiota on thyroidautoimmune  diseases.  .  It  seems,  that  microbiota  has  a  small,  if  any,  effect  on  themetabolism  of  iodine  and  selenium  -  elements  particularly  responsible  for  thyroidhomeostasis. However, the relationship between thyroid function and the gastrointestinaltract has been proven.The human digestive tract is inhabited by hundreds of bacterial species, both aerobicand  anaerobic,  bacteriophages,  viruses  and  fungi  that  collectively  are  referred  to  asintestinal microbiota. [1] Microbiota consists of over a thousand commensal, symbiotic andpathogenic microorganisms. [7] At the time of birth, the composition of the microbiota isrelatively  poor,  with  the  growing  diversity  of  bacteria,  viruses  and  fungi  colonizing  thedigestive tract. In adulthood, it is fairly stable (it undergoes changes in long-term changes indiet, use of medicines, in some diseases).  [1,6] Intestines are mainly an environment forbacteria of the genus  Firmicutes and  Bacterioidetes. It is believed that each person has anindividual set of intestinal bacteria to some extent. Microbiota has a significant impact onthe production and maintenance of immunological, hormonal and metabolic homeostasis. It376takes  part  in  the  digestion,  fermentation  of  nutrients  and  in  energy  storage  processesobtained  in  short-chain  fatty  acids.  In  addition,  it  is  involved  in  the  production  ofneurohormones, vitamins B and K, polyamines as well as mineral homeostasis. Microbiota isalso an important element in the proper functioning of the brain-gut axis and even braindevelopment.  [1,6,7]  Dysbiosis  is  present  in  inflammations,  e.g.  intestinal  inflammation,autoimmune diseases, e.g. multiple sclerosis, type 1 diabetes, rheumatic diseases, metabolicdisorders such as obesity or type 2 diabetes, and mental illness [6,7]Currently,  numerous studies are underway on the effect of microbiota on thyroidautoimmune diseases. The digestive tract is responsible for the absorption of micronutrientsamong  others  iodine  and  selenium,  which  are  necessary  for  the  production  of  thyroidhormones. Iodine is absorbed using the Na / I symprorter. It seems, that microbiota has asmall,  if  any,  effect  on  the  metabolism  of  iodine  and  selenium  -  elements  particularlyresponsible for thyroid homeostasis. [1] However, the relationship between thyroid functionand the gastrointestinal tract has been proven. Triiodiotronine influences the developmentand differentiation of epithelial cells of the intestinal mucosa. [2] Both hypothyroidism andhyperthyroidism give gastrointestinal symptoms. It has been proven that thyroid dysfunctioncan  affect  the  intestinal  bacteria  population.  It  has  been shown that  people  with  overthypothyroidism have a higher risk of bacterial overgrowth in the small intestine. [3,6] Thishyperplasia is explained by gastrointestinal symptoms in these patients. Adequate antibiotictherapy  leads  to  decontamination  and  resolution  of  these  symptoms.  However,  in  thehyperthyroidism, more bacteria of the genus Bifidobacterium, Lactobacillus and Clostridiumand Enterococcus were observed in relation to the healthy population. [6]The most common thyroid dysfunction is Hashimoto disease, involving about 5% ofworld population. It is a chronic, autoimmune thyroiditis leads to hypothyroidim.  In patientswith Hashimoto's disease morphological changes in the distal part of the duodenum wereshown. In the electron microscope, an increased distance between adjacent microvilli and achange in microvilli thickness was observed. These patients have also been diagnosed with377intestinal leakage by a lactulose/mannitol test, resulting in increased permeability to toxins,antigens or bacterial metabolites from the intestine into the bloodstream as compared tothe control group. In this mechanism the effect of microbiota on thyroid disease is quested.[4]The relationship between microbiota and thyroid homeostasis is still not sufficientlystudied. Currently, the "Investigation of Novel biomarkers and Definition of the microbiomeIn Graves' Orbitopathy" (INDIGO) project is being carried out. The aim of the project is toidentify prognostic biomarkers to facilitate early prophylactic intervention, examine the roleof  the  microbiome  in  disease  progression,  and  assess  the  impact  of  probiotics  on  thereduction of Graves' disease. [5]Bibliography:1. J.  Hardina,  A.Banning.,  A  Kipp  i.in:  The  gastrointestinal  microbiota  affects  theselenium status and selenoprotein expression in mice. J.Nutr. Biochem. 2009;20:638-648. 2. C.Virili,  M.Centanni:  Does  microbiota  composition  affect  thyroid  homeostasis?.Endocrine. 2015; 49:583-5873. F. Zhao, J.Feng, J.Li,  L.Zhao I in.: Alterations of the Gut Microbiota in Hashimoto’sThyroiditis Patients. Thyroid. 2018: 2(28): 175-1864. C.Virili,  P  Fallahi,  A.Antonelli,  S.Benvenga,  M.Centanni:  Gut  microbiota  andHashimoto’s thyroiditis. Rev Endocr Metab Disord. Publish online: 08 October 2018.5. H.Kohling,  S.Plummer,  J.  Marchesi,  K.Davidge,  M.Ludgate:  The  microbiota  andautoimmunity:  Their  role  in  thyroid  autoimmune  diseases.  Clinical  Immunology.2017; 183: 63-743786. C.Virili, M. Centanni: “With a little help from my friends” - The role of microbiota inthyroid  hormone metabolism and enterohepatic recycling.  Molecular  and CellularEndocrinology.2017; 458: 39-437. H.  Karakuła-Juchnowicz,  H.  Pankowicz,  D.  Juchnowicz,  J.L.V.  Piedra,  T.  Małecka-Massalska:  Intestinal  microbiota – a  key to understanding the pathophysiology ofanorexia nervosa?. Psychatr. Pol. 2017; 51(5): 859-870.379

Relationship between intestinal microbiota and thyroid homeostasis

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