A methodological guide for retraining courses

Předmětem bakalářské práce je zpracování metodické příručky pro organizaci a pedagogickou přípravu rekvalifikačních kurzů zaměřených na čtení a kreslení technické dokumentace v prostředí počítače. Autorka práce se detailněji věnuje náležitostem akreditace a didaktické stránce rekvalifikačních kurzů. V závěru práce je uveden konkrétní návrh rekvalifikačního kurzu "Čtení a kreslení technické dokumentace" se zaměřením na počítačový software AutoCAD.The purpose of the present bachelor´s thesis is to elaborate a methodological guide for the organization and pedagogical preparation of retraining courses which are focused on reading and drawing technical documentation in the computer environment. The author of the thesis chiefly concentrates on formalities of accreditation and on didactic aspect of retraining courses. The last chapter introduces a specific proposal of retraining course entitled "Reading and drawing of technical documentation" with focalisation in the computer software AutoCAD

BUNDLE BRANCH BLOCKS SIMULATIONS IN VENTRICULAR MODEL WITH REALISTIC GEOMETRY AND CONDUCTION SYSTEM

The goal of the study was to design a model of cardiac ventricles with realistic geometry that enables simulation of the ventricular activation with normal conduction system functions, as well as with bundle branch blocks. In ventricles, electrical activation propagates from the His bundle to the left and right bundle branches and continues to the fascicles and branching fibers of the Purkinje system. The role of these parts of the conduction system is to lead the activation rapidly and synchronously to the left and right ventricle. The velocity of propagation in the conduction system is several times higher than in the surrounding ventricular myocardium. If the conduction system works normally, QRS duration representing the total activation time of the ventricles lies in the physiological range of about 80 to 120 ms but it is more than 120 ms in the case of bundle branch blocks. In our study, the realistic geometry of the ventricles was constructed on the base of a patient CT scan, defining epicardial and endocardial surfaces. The first part of the conduction system (fast-conducting bundle branches, fascicles in the left ventricle and initial parts of the Purkinje fibers) was modeled as polyline pathways isolated from the surrounding ventricular tissue. The remaining part of the Purkinje system was modeled as an endocardial layer with higher conduction velocity. The propagation of the electrical activation in the ventricular model was modeled using reaction-diffusion (RD) equations, except for the first part of the conduction system, where the activation times were evaluated algebraically with respect to predefined velocity of propagation and estimated distance between the His bundle and particular entry point to the layer with higher conduction velocity. Propagation of activation in cardiac ventricles was numerically solved in Comsol Multiphysics environment. Several configurations of the first part of the conduction system with different number of polyline pathways and entry points were proposed and tested to achieve realistic activation propagation. For the model with 9 starting points, realistic total activation time (TAT) of the whole ventricles of about 108 ms was obtained for the model with normal conduction system, and realistic TAT of 126 ms and 149 ms were obtained for the right and left bundle branch block (RBBB, LBBB), respectively. Very similar TAT was found also for the model with 7 starting points, but unrealistically long TAT was obtained in LBBB simulation for the model with only 5 starting points

IMPACT OF THE TORSO MODEL ON THE INVERSE LOCALIZATION OF ISCHEMIA

In this simulation study the accuracy of the inverse localization of an ischemic lesion was investigated if a patientadjusted general torso model and four different approximate heart models were used. Surface ECGs were simulated by a normal heart and by hearts with 18 different ischemic lesions in 7 realistic torso models. Position of each lesion represented by a single dipole was then searched by an inverse solution. Difference QRST integral maps reflecting differences between cardioelectric fields of the ischemic and normal hearts were used. With a standard heart model the mean error of the lesion localization was 3.4 cm. With a standard heart model shifted to an inversely estimated position this error was 3.9 cm, for an equally shifted and properly formed and rotated heart model the error was 2.4 cm and for a heart model properly shifted, formed and rotated the error was 1.1 cm. If realistic CT or MRI-based torso model was used the lesion localization error was 0.7 cm. From the results it can be concluded that use of adjusted standard torso model with properly positioned and formed standard heart model can lead to acceptable accuracy of the inverse localization of an ischemic lesion

Impact of the patient torso model on the solution of the inverse problem of electrocardiography

Cardiac diagnostics based on a solution of the inverse problem of electrocardiography offers new tools for visual assessment of cardiac ischemia. The accuracy of the inverse solution is influenced by fidelity of the patient torso model. As optimum, an individual torso model with real heart shape and position obtained from CT or MRI is desirable. However, imaging is not always available in clinical practice, hence we investigated, if a generic torso shape individually adjusted according to patient†s chest dimensions, with a simplified heart model placed to a vertical position obtained from inverse localization of the early ventricular activation can result in an inverse solution close to the result obtained with an accurate torso model. Simulated inverse localization of 18 ischemic lesions for 9 subjects showed that the use of individually adjusted generic torso instead of real torso shape led to an acceptable increase of the lesion localization error from 0.7±0.7 cm to 1.1±0.7 cm when accurate heart model was used. However, if simplified heart model was used and placed in a vertical position according to the V2 lead level, the lesion localization error increased to 3.5±0.9 cm. Moving the simplified heart model to a position estimated by the inverse solution decreased the vertical heart positioning error from 1.6±2.3 cm to 0.2±1.2 cm but without adjusting the heart shape and rotation the lesion localization error did not improve and reached 3.7±1.0 cm

Evaluation of the Corporate Performance

Bakalářská práce se zabývá hodnocením finanční situace firmy PLASTICO spol. s r.o. v letech 2013–2017. V teoretické části jsou popsány vybrané ukazatele a informační zdroje potřebné pro jejich výpočet. Následně jsou v praktické části hodnoty ukazatelů vypočteny a výsledky vyhodnoceny. Na základě zjištěných hodnot jsou předloženy návrhy na zlepšení situace.The bachelor’s thesis focuses on the evaluation of the financial situation of the company PLASTICO spol. s r.o. in the years 2013–2017. The theoretical part describes selected indicators and information sources necessary for their calculation. Then are indicators used in the practical part and their results evaluated. The suggestions are made to improve the situation.

Mechanisms of insulin resistance in humans with focus on adipose tissue

Endocrine activity of adipose tissue is implicated in the development of insulin resistance (IR). The thesis aimed to extend the knowledge of mechanisms contributing to IR. Study I - To investigate the effect of acute hyperinsulinaemia and acute angiotensin II type 1 receptor blockade (ARB) on plasma concentrations and subcutaneous adipose tissue (SAT) expressions of selected adipokines in patients with type 2 diabetes and healthy controls Study II - To investigate the effect of 3-week telmisartan treatment on insulin resistance and plasma concentrations and SAT expressions of selected adipokines in subjects with metabolic syndrome and impaired fasting glucose (IFG) Study III - To investigate the effect of prolonged hypertriglyceridaemia on plasma concentrations and SAT expressions of selected adipokines in patients with type 2 diabetes and healthy control subjects Study IV - To assess the plasma concentrations and SAT expressions of selected adipokines in subjects with different categories of glucose intolerance Methodology: Hyperinsulinaemic-euglycaemic clamp, Intralipid infusion and saline infusion were used to simulate specific metabolic conditions in vivo in 4 groups: 8 young healthy men, 11 overweight/obese patients with type 2 diabetes, 12 age-matched healthy controls and 12 overweight/obese patients...Units out of CUMimofakultní pracoviště2. lékařská fakultaSecond Faculty of Medicin

Evaluation of the Efficiency of Financial Management of the Selected Municipalities of the Olomouc Region

Diplomová práce se zabývá zhodnocením majetkové efektivity vybraných obcí Olomouckého kraje v letech 2010 – 2019. V teoretické části jsou vymezeny základní pojmy, konkrétně se jedná o postavení obce v rámci veřejné správy a jejich majetkové poměry. Jsou zde charakterizovány jednotlivé náležitosti spojené s obecním rozpočtem. Následně je charakterizován výběrový vzorek a jsou popsány metody, které budou využity pro požadované srovnání vybraných městysů. V poslední části jsou vypočteny a následně zhodnoceny indikátory majetkové efektivity.The thesis deals with evaluation of the efficiency of property of financial management of the selected municipalities of the Olomouc region in years 2010 – 2019. The first part discusses basic concepts, namely the position of the municipality in public administration and their property relations. Then there are characterized the topics connected with the municipal budget. The second part describes selected municipalities and indicators necessary for their calculation. Then are indicators used in practical part of thesis and their results commented.153 - Katedra veřejné ekonomikyvelmi dobř