Creation of an integrated transport system in Frýdek - Místek region

Import 06/11/2014Tato disertační práce se zabývá tvorbou integrovaného dopravního systému na Frýdecko – Místecku a zavedením systému „MHD zdarma“ ve Frýdku - Místku, včetně jeho podrobného popisu. V práci je popsán vývoj počtu přepravených cestujících a výše tržeb z jízdného a jsou zde pojmenovány důvody takového vývoje. Dále je zde podrobně popsán tarif a zdůvodněna jeho struktura, jsou zmíněny pozitivní a negativní vlivy projektu „MHD zdarma“ ve všech oblastech života. Frýdecko – Místecký systém je porovnáván s jinými systémy jak v České republice, tak i ve světě. Vývoj myšlenky „MHD zdarma“ je v práci podrobně popsán a jsou uvedeny možnosti zavedení obdobného systému i v jiných městech. Práce se také zabývá tvorbou integrovaného dopravního systému. Jsou popsány současné integrované dopravní systémy v České republice. V okolí města Frýdek – Místek je navrženo vytvoření dopravního a tarifního řešení integrovaného systému, jehož základem je městská hromadná doprava ve Frýdku – Místku a následně jsou popsány všechny směry, ve kterých integrace probíhá. Všechna data jsou statisticky zpracována. Součástí výpočtů je také výpočet výše dotace od jednotlivých samospráv. Důraz je kladen především na to, aby výše dotace z veřejných rozpočtů nestoupla. V závěru práce jsou popsány možnosti dalšího vývoje systému „MHD zdarma“ a další možnosti integrace okolí města Frýdek – Místek.This dissertation deals with the creation of an integrated transport system in Frýdek-Místek and its surroundings, focusing on and describing the introduction of free public transport in Frýdek – Místek. The paper studies the development of the number of passengers and fare revenues as well the background of its development. The tariff structure with its positive and negative effects is described in detail. Next to this, this dissertation compares other free public transport systems in the Czech Republic and the world. Possibilities of introducing a similar system of free public transport in other towns and cities are discussed as well. My work also deals with the creation of an integrated transport system in general and in comparison with other current integrated transport systems in the Czech Republic. Tariff and transport solutions of the integrated system in Frýdek - Místek and its surroundings are described in detail. All data are statistically processed. The calculations also include the amount of subsidies from various governments on all levels. The emphasis is primarily focused on public budgets, without rising the particular amount of subsidies. In the end, I present the possibilities of further development of the free public transportation and a deepener integration in Frýdek–Místek and its surroundings.Prezenční342 - Institut dopravyvyhově

Mathematical Methods in Traffic Net of Urban Mass Transport Frýdek-Místek City Aplication

Import 31/08/2009Prezenční342 - Institut dopravyvýborn

Line system of Urban Mass Tramsport Frýdek-Místek optimalization

Import 14/08/2007Prezenční342 - Institut doprav

Business report of company Lučební závody a. s. Kolín

Práce se zabývá podrobnou analýzou akciové společnosti. Hlavním cílem této práce je zjištění skutečného stavu podniku, odhalit problémy a navrhnout nápravná opatření k dosažení žádoucího stavu.Ústav ekonomieDokončená práce s úspěšnou obhajobo

Doppler parameters of myocardial dysfunction in very low birth weight infants

Preterm neonate is exposed to significant hemodynamic changes after delivery. Cardiac and extracardiac shunts, especially ductus arteriosus, play an important role in this process. Failure of postnatal adaptation and persistent patent ductus arteriosus (PDA) may lead to cardiac overload and circulatory failure with hypoperfusion of vital organs and in turn adversely affect the short-term and long-term morbidity and mortality of these patients. Newborns with very low birth weight are at highest risk, however the possibilities for diagnosing circulatory failure in this patient group are limited. Clinical presentation and physical examination are nonspecific and involve subjective measures. Functional echocardiography provides information on systolic and diastolic heart function as well as the possibility to measure cardiac output and superior vena cava flow (SVC flow). Much of what is known about ventricular function pertains to systole rather than diastole. Near infrared spectroscopy provides another noninvasive method, enabling the measurement of tissue oxygenation including that of the brain. Cerebral oxygenation can be measured by placing the probe on the head of the neonate. Further possibility to help diagnose circulatory system failure are biochemical markers, commonly used in diagnosing..

Quality system implementation according to ISO 9000/2000 into firm Lučební závody a.s. Kolín

Tato diplomová práce se věnuje zavádění systému jakosti dle ISO 9000 do akciové společnosti Lučební závody a. s. Kolín. Úvodní část se zabývá obecným popisem pojmu jakost – jeho historií a vývojem, požadavky na ni, řízením jakosti, politikou jakosti a tak dále. Ve druhé části je charakterizována akciová společnost, zhodnocena analýza současného stavu systému jakosti. Systém jakosti ve společnosti je certifikován podle normy ISO 9001. Hlavní částí této práce je zavádění systému jakosti do společnosti a jeho dokumentace – jako například příručka jakosti. V poslední části jsou shrnuty přínosy tohoto systému jakosti pro společnost a naznačen jeho další vývoj.This thesis is devoted to implementing a quality system according to ISO 9000 into the firm Lučební závody a.s. Kolín. The exordium concerns general description of quality – its history and development, demands on it, quality control, politics of quality and so on. In the second part the joint-stock company is characterized as well as the analysis of current situation of the quality system. The quality system according to ISO 9001 is certificated. The main part of this work is in the implementation of quality system to the company and its documentation – for example, as quality manual. The last part summarizes benefits of this system for the company and future needed procedures are proposed.Ústav ekonomiky a managementuDokončená práce s úspěšnou obhajobo

Cord Blood Extracellular Vesicles Analyzed by Flow Cytometry with Thresholding Using 405 nm or 488 nm Laser Leads to Concurrent Results

Extracellular vesicles (EVs) from liquid biopsies are extensively analyzed by flow cytometry, a technology that is continuously evolving. Thresholding utilizing a violet 405 nm laser side scatter (VSSC) has recently been implemented. Here, we collected set of large EV (lEV) samples from cord blood, which we analyzed using a standard flow cytometer improved via a 405 nm laser side scatter. Samples were analyzed using two distinct thresholding methods—one based on VSSC, and one based on VSSC combined with fluorescence thresholding on stained phosphatidylserine. Through these thresholding methods, we compared lEVs from pre-term births and control cord blood. Double-labeled lEVs with platelet CD36+/CD41+, activated platelet CD41+/CD62P+ and endothelial CD31+/CD105+ antibodies were used. Apart from comparing the two groups together, we also correlated measured lEVs with the thresholding methods. We also correlated the results of this study with data analyzed in our previous study in which we used a conventional 488 nm laser SSC. We did not find any difference between the two cord blood groups. However, we found highly concurrent data via our correlation of the thresholding methods, with correlation coefficients ranging from 0.80 to 0.96 even though the numbers of detected lEVs differed between thresholding methods. In conclusion, our approaches to thresholding provided concurrent data and it seems that improving the cytometer with the use of a VSSC increases its sensitivity, despite not being particularly critical to the validity of flow cytometric studies that compare pathological and physiological conditions in liquid biopsies

Cerebral Oximetry Monitoring in Extremely Preterm Infants

BACKGROUND The use of cerebral oximetry monitoring in the care of extremely preterm infants is increasing. However, evidence that its use improves clinical outcomes is lacking. METHODS In this randomized, phase 3 trial conducted at 70 sites in 17 countries, we assigned extremely preterm infants (gestational age, <28 weeks), within 6 hours after birth, to receive treatment guided by cerebral oximetry monitoring for the first 72 hours after birth or to receive usual care. The primary outcome was a composite of death or severe brain injury on cerebral ultrasonography at 36 weeks' postmenstrual age. Serious adverse events that were assessed were death, severe brain injury, bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and late-onset sepsis. RESULTS A total of 1601 infants underwent randomization and 1579 (98.6%) were evaluated for the primary outcome. At 36 weeks' postmenstrual age, death or severe brain injury had occurred in 272 of 772 infants (35.2%) in the cerebral oximetry group, as compared with 274 of 807 infants (34.0%) in the usual-care group (relative risk with cerebral oximetry, 1.03; 95% confidence interval, 0.90 to 1.18; P = 0.64). The incidence of serious adverse events did not differ between the two groups. CONCLUSIONS In extremely preterm infants, treatment guided by cerebral oximetry monitoring for the first 72 hours after birth was not associated with a lower incidence of death or severe brain injury at 36 weeks' postmenstrual age than usual care. (Funded by the Elsass Foundation and others; SafeBoosC-III ClinicalTrials.gov number, NCT03770741.)

Cerebral Oximetry Monitoring in Extremely Preterm Infants

Background: The use of cerebral oximetry monitoring in the care of extremely preterm infants is increasing. However, evidence that its use improves clinical outcomes is lacking. Methods: In this randomized, phase 3 trial conducted at 70 sites in 17 countries, we assigned extremely preterm infants (gestational age, &lt;28 weeks), within 6 hours after birth, to receive treatment guided by cerebral oximetry monitoring for the first 72 hours after birth or to receive usual care. The primary outcome was a composite of death or severe brain injury on cerebral ultrasonography at 36 weeks' postmenstrual age. Serious adverse events that were assessed were death, severe brain injury, bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and late-onset sepsis. Results: A total of 1601 infants underwent randomization and 1579 (98.6%) were evaluated for the primary outcome. At 36 weeks' postmenstrual age, death or severe brain injury had occurred in 272 of 772 infants (35.2%) in the cerebral oximetry group, as compared with 274 of 807 infants (34.0%) in the usual-care group (relative risk with cerebral oximetry, 1.03; 95% confidence interval, 0.90 to 1.18; P = 0.64). The incidence of serious adverse events did not differ between the two groups. Conclusions: In extremely preterm infants, treatment guided by cerebral oximetry monitoring for the first 72 hours after birth was not associated with a lower incidence of death or severe brain injury at 36 weeks' postmenstrual age than usual care. (Funded by the Elsass Foundation and others; SafeBoosC-III ClinicalTrials.gov number, NCT03770741.)