The didactic strategy in germanicus’ translation of aratus’ phaenomena

Germanicus Iulius Caesar translated Aratus’ Phaenomena when the Roman interest in astronomy and astrology was on the rise. The Romans, including the imperator, were amazed by the fact that with the knowledge of the motion of celestial objects one can predict the future. And people wanted to learn more about the stars and the constellations. Did Germanicus’ work perform the task of teaching its readers about the heavens? Did he manage to play his role as a teacher? Did he only translate the information contained in Aratus’ text, or did he transfer even the didactic aspect of the poem? And how did he try to make the lecture more interesting? Did he make an attempt to interact with the reader? In this paper, Germanicus’ text will be examined focusing on his didactic strategy. The core of the paper is the analysis of manners used by Germanicus to meet characteristic constituent features of the genre of didactic poetry, which will be briefly introduced in the beginning

Nursing process in a woman with monochorionic twin pregnancy.

Tématem této bakalářské práce je monochoriální dvojčetná gravidita. Práce je členěna na část teoretickou a část praktickou. V teoretické části je nejprve uvedena stručná klasifikace jednotlivých typů dvojčat. Dále se práce zaměřuje na monochoriální graviditu ̶ na prenatální péči, charakteristické komplikace a rizika, vedení a časování porodu. V praktické části práce je uvedena kazuistika ženy s monochoriální dvojčetnou graviditou, u které byl diagnostikován transfuzní syndrom dvojčat (twin to twin transfusion syndrom; TTTS). Kazuistika obsahuje základní identifikační údaje o těhotné, anamnézu, popis průběhu hospitalizace a plán ošetřovatelské péče o ženu s monochoriální dvojčetnou graviditou. Cílem práce je komplexně a přehledně popsat problematiku monochoriální dvojčetné gravidity. Cílem praktické části je na konkrétním kazuistickém případu demonstrovat průběh péče a realizaci ošetřovatelského procesu u ženy s touto diagnózou. Ošetřovatelský proces je realizován podle modelu ošetřovatelské péče dle Marjory Gordonové. Práce je určena studentkám porodní asistence a porodním asistentkám v praxi zajímajícím se o danou problematiku. Klíčová slova: vícečetné těhotenství, monochoriální dvojčata, komplikace monochoriální gravidity, twin to twin transfusion syndromThe topic of this bachelor thesis is monochorionic twin pregnancy. The thesis is divided into a theoretical and a practical part. The theoretical part briefly introduces different types of twins. Then it concerns itself with monochorionic twin pregnancy ̶ with prenatal care, typical complications and risks related to this type of pregnancy and also with timing and conduction of labour. In the practical part of this thesis, we are presented with a case study of monochorionic diamniotic twin pregnancy complicated by twin to twin transfusion syndrome (TTTS). The case study contains basic identification of the pregnant woman, her medical history, a description of her hospital stay and a nursing plan for the pregnant woman. The objective of this thesis is to comprehensively describe monochorionic twin pregnancy. The practical part then aims to illustrate the hospital care and the execution of a nursing plan on a case study of a woman diagnosed with monochorionic twin pregnancy. The nursing plan is executed in line with the Gordon's functional health patterns model. This thesis is intended for midwifery students and midwives interested in this matter. Keywords: multiple pregnancy, monochorionic twins, complications of monochorionic twin pregnancy, twin to twin transfusion syndromGynekologicko-porodnická klinika 1. LF UK a VFNDepartment of Obstetrics and Gynaecology First Faculty of Medicine and General University Hospital1. lékařská fakultaFirst Faculty of Medicin

Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins

Objective: Oral squamous cell carcinoma (OSCC) originates from the mucosal lining of the oral cavity. Almost half of newly diagnosed cases are classified as advanced stage IV disease, which makes resection difficult. In this study, we investigated the pathological features and mutation profiles of tumor margins in OSCC. Methods: We performed hierarchical clustering of principal components to identify distinct patterns of tumor growth and their association with patient prognosis. We also used next-generation sequencing to analyze somatic mutations in tumor and marginal tissue samples. Results: Our analyses uncovered that the grade of worst pattern of invasion (WPOI) is strongly associated with depth of invasion and patient survival in multivariable analysis. Mutations were primarily detected in the DNA isolated from tumors, but several mutations were also identified in marginal tissue. In total, we uncovered 29 mutated genes, mainly tumor suppressor genes involved in DNA repair including BRCA genes; however none of these mutations significantly correlated with a higher chance of relapse in our medium-size cohort. Some resection margins that appeared histologically normal harbored tumorigenic mutations in TP53 and CDKN2A genes. Conclusion: Even histologically normal margins may contain molecular alterations that are not detectable by conventional histopathological methods, but NCCN classification system still outperforms other methods in the prediction of the probability of disease relapse.Web of Science13art. no. 128765

Updating algal evolutionary relationships through plastid genome sequencing: did alveolate plastids emerge through endosymbiosis of an ochrophyte?

Algae with secondary plastids of a red algal origin, such as ochrophytes (photosynthetic stramenopiles), are diverse and ecologically important, yet their evolutionary history remains controversial. We sequenced plastid genomes of two ochrophytes, Ochromonas sp. CCMP1393 (Chrysophyceae) and Trachydiscus minutus (Eustigmatophyceae). A shared split of the clpC gene as well as phylogenomic analyses of concatenated protein sequences demonstrated that chrysophytes and eustigmatophytes form a clade, the Limnista, exhibiting an unexpectedly elevated rate of plastid gene evolution. Our analyses also indicate that the root of the ochrophyte phylogeny falls between the recently redefined Khakista and Phaeista assemblages. Taking advantage of the expanded sampling of plastid genome sequences, we revisited the phylogenetic position of the plastid of Vitrella brassicaformis, a member of Alveolata with the least derived plastid genome known for the whole group. The results varied depending on the dataset and phylogenetic method employed, but suggested that the Vitrella plastids emerged from a deep ochrophyte lineage rather than being derived vertically from a hypothetical plastid-bearing common ancestor of alveolates and stramenopiles. Thus, we hypothesize that the plastid in Vitrella, and potentially in other alveolates, may have been acquired by an endosymbiosis of an early ochrophyte

Three Periods of the Magazine Vlasta - Its Reflection of the Social and Political Situation

Liberal Arts and Humanities - Social Sciences ModuleStudium humanitní vzdělanosti - Společenskovědní modulFaculty of HumanitiesFakulta humanitních studi