Turbocharger Test Stand

Diplomová práce se zabývá problematikou testování turbodmychadel. Úkolem práce je provést dostupnou rešerši o zkušebních stanovištích. Dále navrhnout konstrukci měřícího stanoviště. Součástí práce je vytvoření obslužného programového vybavení pro dostupné měření. Vytvořený program bude sloužit jako základ pro kontrolu měřených dat turbodmychadla.The Diploma thesis deals with the testing of turbochargers. Aim of this work is to perform a search on a teststands. Further suggest the teststand's construction. Part of the work is the creation of software for utility measurements available. The program will serve as a basis for checking the measurement data of the turbocharger.

Experimental Evaluation of Modified Groundhook Car Suspension with Fast Magnetorheological Damper

The car suspension setting is always a trade-off between comfort and handling. The semi-active damper system seems to be an option for reducing the compromise between the two demands. This paper deals with the effect of the magnetorheological damper setting on a car’s suspension performance, especially tire grip, which was directly measured. A unique test rig was developed, and an experimental trolley with a fast magnetorheological damper (response time of 3 µs) was used in the paper. The damper was controlled by a modified Groundhook algorithm. Compared with the passive regime, the experiments showed a 30% improvement when using the Groundhook algorithm and when the damper was adequately set. The experiments proved the trends that were set by simulations

The Taiwan-China economic relationship

This thesis summarizes the development of economic relations between the PRC and Taiwan with an emphasis on the last three decades. The main objective is to answer the question of how the development of the political status of Taiwan affected the economic relations with the PRC and what the consequences for both countries are.Tato bakalářská práce pojednává o vývoji hospodářských vztahů mezi ČLR a Tchaj-wanem s důrazem na poslední tři dekády. Hlavním cílem je odpovědět na o otázku, jaký vliv měl vývoj politického statusu Tchaj-wanu na vzájemné hospodářské vztahy s ČLR a jaké důsledky z toho pro obě země plynou

Výpočetní studie interakcí organokovových komplexů s modely DNK/RNK a proteinů s využitím nástrojů kvantové chemie a molekulové mechaniky .

Methods of computational chemistry represent an important tool in development of novel materials or drugs. In this thesis, they are used for investigation of Pt anticancer drugs. Interaction of five hydrated Pt(II) complexes with guanine as a small model of DNA is studied at the DFT level. Several Pt(IV) complexes exhibit less side effects and overcome some resistances of cisplatin, nevertheless they must be reduced to their Pt(II) analogues to obtain anticancer activity due to their high kinetic inertness. Therefore, reduction potentials for eleven Pt(IV) complexes are determined using DFT and post-Hartree-Fock methods. The kinetics of reduction play more important role. Thus, we study reaction mechanisms for reduction of tetraplatin by deoxyguanosine monophosphate and satraplatin by ascorbic acid. In both mechanisms the kinetic model for side reactions is employed since reducing agents occur in different protonation states. From the perspective of interaction of metals with thymine, proton transfer is of great importance. It is shown that the presence of hydrated metal cations - Mg2+ , Zn2+ , Hg2+ leads to a significant decrease of activation barriers for the N3↔O3 proton transfer. The QM/MM umbrella sampling MD method is employed in a study of binding of the hydrated mercury cation to the N3 position in...Při vývoji nových materiálů či léčiv zaujímají v poslední době kvantově-chemické metody důležitou roli. V rámci této disertační práce jsou využity při studiu platinových komplexů představujících potencionální protirakovinná léčiva. Interakce pěti hydratovaných Pt(II) komplexů s guaninem je studována pomocí DFT metod. U cytostatik na bázi Pt(IV) komplexů je však pozorováno méně vedlejších účinků a zároveň překonávají rezistenci některých nádorů vůči cisplatině. Obecně jsou ale vysoce kinecky inertní, a proto musí být v organismu redukovány, aby bylo dosaženo jejich protirakovinné aktivity. Z tohoto důvodu jsou stanoveny redukční potenciály pro jedenáct Pt(IV) komplexů pomocí DFT výpočtů a post-Harteeho-Fockových metod. Kinetika však hraje zásadní roli v případě redukce těchto sloučenin, a proto je zkoumán reakční mechanismus odpovídající redukci tetraplatiny v přítomnosti deoxyguanosin monofosfátu a redukci satraplatiny pomocí kyseliny askorbové. Jelikož se uvažovaná redukční činidla vyskytují při neutrálním pH v různých protonačních stavech, efektivní rychlostní konstanty jsou stanoveny pomocí vztahů pro boční reakce. Při interakci kovových kationtů s thyminem představují přenosy protonů velmi důležitou část reakce. Přítomnost hydratovaných Mg2+ , Zn2+ , Hg2+ kationtů vede k výraznému snížení aktivační...Katedra chemické fyziky a optikyDepartment of Chemical Physics and OpticsFaculty of Mathematics and PhysicsMatematicko-fyzikální fakult

Computational Study of the Interactions of Transition Metal Complexes with Biomolecules Using Quantum Chemical Methods.

It has been proven that platinum complexes are active in anticancer treatment as well as several other transition metals. There is an effort in recent medicine to replace cisplatin complexes by drugs with smaller side effects. This work focuses on the reaction of 5'-dGMP (2'-deoxyguanosine- 5'˗monophosphate) with a platinum complex PtIV (dach)Cl4 (dach=diaminocyclohexane) forming PtIV (dach)Cl3(N7-cGMP) complex. The explored reaction can be divided into two (independent) steps: cyclization of phosphate and substitution reaction where a new complex with coordinate- covalent bond between platinum atom and nitrogen N7 of guanine is formed releasing chloride particle. Here I studied geometry parameters which are important in the above mentioned reaction. The reaction course is observed from the thermodynamic point of view. The structures were optimized at the DFT level with B3LYP functional in basis set 6-31G* and PCM/UA0 solvation model. The energy parameters and electron density distribution were computed at the B3LYP/6˗311++G(2df,2pd) level in the D˗PCM/sUAKS solvation model

Computational Study of Organometallic Interactions with Models of DNA/RNA and Proteins Using Tools of Quantum Chemistry and Molecular Mechanics.

Methods of computational chemistry represent an important tool in development of novel materials or drugs. In this thesis, they are used for investigation of Pt anticancer drugs. Interaction of five hydrated Pt(II) complexes with guanine as a small model of DNA is studied at the DFT level. Several Pt(IV) complexes exhibit less side effects and overcome some resistances of cisplatin, nevertheless they must be reduced to their Pt(II) analogues to obtain anticancer activity due to their high kinetic inertness. Therefore, reduction potentials for eleven Pt(IV) complexes are determined using DFT and post-Hartree-Fock methods. The kinetics of reduction play more important role. Thus, we study reaction mechanisms for reduction of tetraplatin by deoxyguanosine monophosphate and satraplatin by ascorbic acid. In both mechanisms the kinetic model for side reactions is employed since reducing agents occur in different protonation states. From the perspective of interaction of metals with thymine, proton transfer is of great importance. It is shown that the presence of hydrated metal cations - Mg2+ , Zn2+ , Hg2+ leads to a significant decrease of activation barriers for the N3↔O3 proton transfer. The QM/MM umbrella sampling MD method is employed in a study of binding of the hydrated mercury cation to the N3 position in..

Computational Study of the Interactions of Transition Metal Complexes with Biomolecules Using Quantum Chemical Methods.

It has been proven that platinum complexes are active in anticancer treatment as well as several other transition metals. There is an effort in recent medicine to replace cisplatin complexes by drugs with smaller side effects. This work focuses on the reaction of 5'-dGMP (2'-deoxyguanosine- 5'˗monophosphate) with a platinum complex PtIV (dach)Cl4 (dach=diaminocyclohexane) forming PtIV (dach)Cl3(N7-cGMP) complex. The explored reaction can be divided into two (independent) steps: cyclization of phosphate and substitution reaction where a new complex with coordinate- covalent bond between platinum atom and nitrogen N7 of guanine is formed releasing chloride particle. Here I studied geometry parameters which are important in the above mentioned reaction. The reaction course is observed from the thermodynamic point of view. The structures were optimized at the DFT level with B3LYP functional in basis set 6-31G* and PCM/UA0 solvation model. The energy parameters and electron density distribution were computed at the B3LYP/6˗311++G(2df,2pd) level in the D˗PCM/sUAKS solvation model

Quantum chemical study of the electron properties of various platinum(IV) complexes and their reaction mechanisms

It has been proven that platinum complexes are active in anticancer treatment as well as several other transition metals complexes. There is an effort in recent medicine to replace cisplatin complexes by drugs with smaller side effects. This work focuses on the reaction of 5'-dGMP (2'-deoxyguanosine-5'˗monophosphate) and cGMP (cyclic 2'-deoxyguanosine- monophosphate) with a platinum complex PtIV (dach)Cl4 (dach=diaminocyclohexane). In these two cases the Pt(IV) complex is only reduced in the presence of 5'-dGMP. The first part of the explored mechanism is the substitution reaction where a coordinate-covalent bond between platinum and nitrogen N7 of guanine is formed. In the next step oxygen of phosphate group is transferred to the C8 site. Subsequently the Pt(IV) complex is reduced. The final products represent 8˗oxo˗GMP and PtII (dach)Cl2, which are active in anticancer treatment in comparison with the kineticly inert reactant. The substitution of a chloride anion ends the reaction path for cGMP forming PtIV (dach)Cl3(N7-cGMP) complex. The structures were optimized at the DFT level with B3LYP functional in the basis set 6-31G(d) and PCM/UA0 solvation model. The energy parameters were computed at the B3LYP/6˗311++G(2df,2pd) level in the IEFPCM/sUAKS solvation model. Finally, the rate constants were..

The Taiwan-China economic relationship

This thesis summarizes the development of economic relations between the PRC and Taiwan with an emphasis on the last three decades. The main objective is to answer the question of how the development of the political status of Taiwan affected the economic relations with the PRC and what the consequences for both countries are

New Cryptographic Key Management for Smart Grid

A smart grid is a simple upgrade of a power grid, which delivers electricity from suppliers to consumers. It uses two-way digital communication in order to control appliances at consumers’ households. Such system saves energy, reduces costs and increases reliability and transparency. It includes smart meters, which enable communication with the central system. Unlike home energy monitors, smart meters can gather data for remote reporting. In spite of the fact that deployment of a smart grid is enormously beneficial, several security and privacy concerns arise. An attacker could possibly intercept traffic going to the central system, send commands to the smart meters or inject code into the backend control system. Security for such systems covers both key management on a scale involving a large number of credentials and keys, and local cryptographic processing on the sensors such as encryption and digital signatures. Current practice for smart meters utilizes several methods for maintaining security, however none of them is considered to be sufficiently efficient. In this study, contemporary methods for key management in a smart grid will be examined and evaluated for one specific scenario. Due to the fact that the current systems have to operate with a large amount of data, the key factor for this analysis will be limited space and computation power. Consequently, design of a new economic key management in combination with efficient cryptography will be designed