Fragility Analysis of Atmospheric Storage Tanks by Observational and Analytical Data

In this research, seismic fragility analysis of storage tanks is carried out with a large damage database from past earthquakes and analytical studies. At the fragility analysis, a new damage state has been defined. Peak ground acceleration is employed as an intensity measure. Epistemic and aleatory uncertainties are considered. At the observational fragility analysis, logit, probit and cumulative lognormal model and maximum likelihood method are utilized. In this research, Finite Element Analysis is also performed. As a result, new seismic fragility curves for storage tanks obtained and compared with the existing tank fragility curves in the literature

Meyerson Phenomenon as a Component of Melanoma in situ

No abstract available</p

Meyerson Phenomenon as a Component of Melanoma in situ

No abstract available</p

Düzlem Çubuk Eleman Rijitlik Matrisinin Deneysel Olarak Belirlenmesi

Konferans Bildirisi -- Teorik ve Uygulamalı Mekanik Türk Milli Komitesi, 2015Conference Paper -- Theoretical and Applied Mechanical Turkish National Committee, 2015Yapısal sistemlerin sayısal analizleri içinde en yaygın kullanım alanına sahip olan sonlu elemanlar metodunun uygulanması sırasında her bir elemana ait serbestlik derecelerinde oluşan deplasman ve kuvvetlerin ilişkisi eleman rijitlik matrisleri ile oluşturulur. Bu çalışmanın amacı, elastik bölgede davranış gösteren çelik malzemeli bir düzlem çubuk elemanına ait rijitlik matrisinin deneysel çalışmalarla elde edilmesi ve teorik rijitlik matrisiyle karşılaştırılarak oluşan farklılıkların irdelenmesidir. Deneysel çalışmalar iki aşamalı olarak yürütülmüştür. Çalışmanın ilk aşamasında deneylerde kullanılacak numunelere ait mekanik malzeme özellikleri çekme testleri yapılarak belirlenmiştir. İkinci aşamada ise altı serbestlik dereceli yük ve deplasman hücresi kullanılarak deney düzeneği hazırlanmış ve rijitlik matrisinin ilgili terimleri birim yüklemeler yapılarak deneysel olarak belirlenmiştir. Ardından deneysel olarak belirlenen rijitlik matrisi teorik sonuçlarla karşılaştırılmış ve oluşan farklılıkların nedenleri irdelenmiştir. Yapılan deneyler sonucunda elde edilen rijitlik matrisi ve teorik rijitlik matrisinin ilgili terimlerinin birbirlerine oldukça yakın olduğu görülmüştür.In finite element method which is one of the most widely used numerical analysis method of structural systems, forces and displacements are related by stiffness matrix. The aim of this study is to determine the stiffness matrix of plane frame element by experimentally. Experimental studies are performed in two stages. In the first stage, tensile tests are done to determine the mechanical properties of the specimens. In the second stage, coefficients of stiffness matrix is determined experimentally using Load and Boundary Conditions Box (LBCB) which has ability to generate displacements and rotations in six degree of freedom by applying unit displacements. Then the related coefficients of stiffness matrix is compared with theoretical ones and reasons of deviations are examined. According to the results, it is observed that the values of related coefficients are quite close to each other

Application of Fractional SPRSPR Psychological Disease Model in Turkey and Stability Analysis

Psychological diseases and their treatment are problems related to public health. According to data from the World Health Organization, about a billion people have either mental illness or substance use disorder problems in 2017. Mental, neurological diseases and substance use disorders account for 30 percent of the global non-fatal disease burden and 10 percent of the global disease burden. It is noted that in the world Dec 2005 and 2015, the incidence of mental health diseases increased by about 16 percent. In this study, we have created a fractional-order mathematical modeling for the population of individuals suering from psychological diseases in a society. In this model, the total population was divided into three compartments: individuals who did not receive psychological treatment (S), individuals who received psychological support (P) and individuals who recovered after completing psychological treatment (R). As a fractional derivative, we used the Caputo derivative definitions. Numerical solutions were obtained with the help of Euler method by performing stability analysis related to the fractional SPR model created for the mathematical model of psychological patients. Thus, it was interpreted by creating dynamics for the number of individuals with psychological problems in a population

Evaluation of Sleep and Television Viewing Habits of Primary School Students

Objective: Sleep is crucial for healthy growth and development of children. Unsuitable television viewing habits are one of the important factors that disturb sleep patterns. This study was conducted to evaluate the sleep and television viewing habits of primary school students. Materials and Methods: The study was conducted as a descriptive study. The data were collected from parents of students aged 6-11 years, who were studying at a primary school between December 2016 and February 2017. The study sample consisted of 299 parents. In order to collect data, a personal information form, an information form to determine television viewing habits and the Children’s Sleeping Habits Questionnaire were administered to the study subjects. Percentages, means, standard deviations, frequencies, and analysis of variance were used to evaluate the data. Ethical permission and consent from the parents were taken for conducting the study. Results: The mean age of the children was 8.64±1.16, and the parents’ mean age was 35.55±6.23. The mean number of hours spent viewing television was 5.62 hours per day. The mean sleep time of the children was 9.37 hours. The mean total score obtained from Children’s Sleeping Habits Questionnaire was determined to be 47.92±8.18. Conclusion: It was found that the child’s success at school, the television viewing time during the weekday, the child’s preference for viewing time, the response to being asked to turn the television off, and the parents’ viewing time significantly affected the total Children’s Sleeping Habits Questionnaire score. A significant difference was found between parental income status, educational status, school success, bedtime resistance, and sleep duration. Also, a significant difference was found between television viewing habits and at least one sleep problem, except night wakes

Onychomatricoma masquerading as candidal onychomycosis and paronychia

Onychomatricoma is a benign slow-growing fibroepithelial tumor arising from the nail matrix. The tumor has been described as a new entity almost two decades ago. Although the clinical appearance is typical, most cases are probably misdiagnosed by physicians because of unfamiliarity with the condition. Herein we describe a case of onychomatricoma masquerading as candidal onychomycosis and paronychia and treated erroneously as such. We believe that OM is still an unrecognized entity and probably more common than cited in the relevant literature. Awareness of the condition not only offers accurate diagnosis and appropriate management but also precludes the long-term use of potentially toxic oral antifungal medications. </span

COMPARISON OF THE ANTHROPOMETRIC DATA AND NUTRITIONAL CHARACTERISTICS AMONG THE BREASTFED AND FORMULA-FED BABIES AND THE RELATION OF THESE PARAMETERS TO INSULIN AND IGF-1 IN EARLY INFANCY

Amaç: Anne sütü ve formüla ile beslenen erken süt çocukluğu dönemindeki bebeklerin antropometrik verilerinin ve beslenme özelliklerinin karşılaştırılması ve bu verilerle beslenme davranışının ve enerji metabolizmasının düzenlenmesinde görev alan insülin ve IGF-1 hormonları arasındaki ilişkinin araştırılması. Gereç ve yöntem: Dokuz Eylül Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Çocuk Polikliniği'ne kontrol amacı ile getirilen ve yaşları 3-4 ay arasında değişen sağlıklı bebekler çalışmaya alındı. Bebekler yalnızca anne sütü (AS) ile beslenenler ve çeşitli nedenlerden dolayı ilk ay içinde anne sütü kesilip formüla ile beslenenler (F) olarak iki gruba ayrıldı; doğum haftaları, doğum ağırlıkları, bebeklerin beslenme özellikleri sorgulandı; vücut ağırlığı, boyu, baş çevresi ve triseps cilt kıvrım kalınlığı (TCKK) ölçüldü ve vücut kitle indeksi (VKİ) hesaplandı. Bebeklerin beslenme öncesi insülin, IGF-1 ve kan şekeri düzeylerini belirlemek üzere venöz kan örnekleri alındı. Bebeklerin 6. ay kontrollerinde, ek gıdalara geçiş zamanı, beslenme özellikleri ve dışkılama paterni sorgulandı; vücut ağırlığı, boyu, baş çevresi ve TSF'si ölçüldü; VKİ, enerji ve protein alımları hesaplandı. Bulgular: Çalışmada yer alan 47 sağlıklı bebeğin (erkek/kız=25/22) 24'ü AS, 23'ü F grubunda idi. İki grup arasında cinsiyet, doğum ağırlığı ve doğum haftası özellikleri bakımından fark yoktu. Üçüncü ayda yapılan ilk değerlendirmede AS grubundaki bebeklerin vücut ağırlığı, boy, TSF, postnatal kilo artışı, beslenme sıklığı ve süresi daha fazla idi (p<0,05). Altıncı ayda AS grubundaki bebeklerin 16'sında (%73), F grubundakilerin 19'unda (%95) ek gıdaya geçilmişti. Ek gıdalardan alınan enerji ve protein F grubunda daha fazla idi (p<0,05). Bu dönemde iki grup arasındaki antropometrik ölçüm farkları ortadan kalkmıştı. Anne sütü ve F grubundaki bebeklerin kan şekeri düzeyleri arasında fark olmamasına ve F grubundakilerin daha zayıf olmalarına karşın, serum insülin düzeyleri F grubunda istatistiksel olarak anlamlı olmamakla birlikte daha yüksek idi. Formüla grubunun ortalama serum IGF-1 düzeyi daha yüksek olarak bulundu (p<0,05). Tüm bebeklerde serum IGF-1 düzeyi arttıkça, 6. ayda ek gıdalardan alınan enerji ve protein miktarı, vücut ağırlığı, VKİ, TCKK ve 3.aydan 6. aya kadar alınan kilo miktarı da artmakta idi (sırasıyla r=0,350, p<0,05; r=0,400, p<0,05; r=0,455, p<0,05; r=0,524, p<0,05; r=0,461, p<0,05). Sonuç: Serumdaki IGF-1 düzeylerinin ikinci üç aylık dönemde enerji, protein ve kilo alımı ile ilişkili olması, bu hormonun ileri yaşlarda vücut ağırlığının düzenlenmesinde önemli rol oynadığını düşündürmektedir. Formüla alan bebeklerde relatif olarak daha yüksek bulunan insülin düzeyleri, bu bebeklerin ek gıdalardan neden daha yüksek enerji ve protein aldıklarının açıklaması olabilir. Objective: Comparison of the anthropometric data and nutritional characteristics among the breastfed and formula-fed babies in early infancy and evaluation of the relation of these parameters to the hormones insulin and IGF-1that are involved in the regulation of nutritional habits and energy metabolism. Materıal and method: Three to four month-old healthy babies evaluated during routine clinical visits in Dokuz Eylül University Medical Faculty Department of Pediatrics were enrolled in the study. The babies were splitted into two groups as breastfed (BF) and formula-fed (FF). Gestational age, birth weight, and nutritional characteristics of the babies were asked; weight, height, head circumference and triceps skin fold thickness (TSF) were measured and body mass index (BMI) was calculated. While fasting venous blood samples of all the babies were obtained for insulin, IGF-1 and glucose measurement. The babies were re-evaluated at 6th postnatal month for weaning time, nutritional characteristics, weight, height, head circumference, TSF, BMI and daily protein intake. Results: There were 47 babies (male/female = 25/22), 24 in BF and 23 in FF groups. Two groups were not different with respect to sex, birth weight and gestational age. Weight, height, TSF, postnatal weight gain, feeding frequency and length were higher in BF group than FF group at first visit in 3-4 months of age (p<0.05). At 6th month, 16 (73%) and 19 (95%) of the babies had weaned in the BF and FF groups, respectively. The energy and protein intake by supplemental foods was higher in FF group (p<0.05). At that time, the differences in anthropometric measurements were over among two groups. Although blood glucose levels were not different among the BF and FF group and the babies in FF group were leaner, serum insulin levels were higher, although not significantly, in FF group. IGF-1 levels were significantly higher in the FF group (p<0.05). As the serum IGF-1 level increased, energy and protein intake by supplemental foods, weight, BMI, TSF and weight gain from 3 to 6 months of age increased in all babies (r=0.350, p<0.05; r=0.400, p<0.05; r=0.455, p<0.05; r=0.524, p<0.05 and r=0.461, p<0.05, respectively). Conclusion: The relation of serum IGF-1 level to energy and protein intake and weight gain in the second 3 month-period of life implies that this hormone play a role in regulation of body weight similar to leptin in later life. Relatively higher levels of serum insulin in FF group might explain the higher energy and protein intake from the supplemental foods in these babies

The impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors

Objective: The development of bioinformatics and comprehensive genomic profiling (CGP) has provided insights into the ap-plicability and functionality of the genomic alterations (GA). In this study, we evaluated the impact of CGP on the treatment plan and outcomes in a significant number of patients. Material and Methods: We carried out a retrospective case-control study on 164 adult patients with advanced solid tumors from 15 oncology centers in Türkiye. Results: In all cases, CGP was performed within 23.8 [standard deviation (SD)±32.1] months of initial diagnosis. Non-small cell lung carcinoma, breast cancer, unknown primary carcinoma, colorectal carcinoma, and sarcoma were among the most common tumor types, accounting for 61.5% of all cases. CGP was performed immediately after the diagnosis of advanced cancer in 13 patients (7.9%). In 158 patients (96.4%), at least one GA was found as per the CGP report. Also, in the reports, the average tumor mutational burden (TMB) and GAs were 7.3 (SD±8.7) mut/Mb and 3.5 (SD±2.0), respectively. According to CGP reports, 58 patients had 79 evidence-based drug suggestions for their particular tumor type, whereas 97 patients had 153 evidence-based drug suggestions for another tumor type. After the primary oncologist interpreted the CGP reports, significant changes were made to the treatment of 35 (21.3%) patients. Conclusion: We strongly believe that in the future, high-TMB or other tumor-agnostic biomarkers will become much more afford-able, and CGP will serve as one of the major decision-making tools for the treatment of patients along with pathological, radiological or lab-oratory tests