Characteristics of school injuries presenting to the emergency department

School injuries account for approximately one-fifth of pediatric injuries. We aimed to investigate the frequency and severity of school injuries among school-aged children and determine clinical diagnoses and surgery requirement data. Methods In this prospective study, children who were admitted to the emergency department due to school accidents over a 5-month period were included. Demographics, activity during trauma, mechanism of trauma, nature, severity, emergency department outcomes, and surgery requirement were evaluated. Results The study included a total of 504 school-aged children, of whom 327 (64.9%) were male and 177 (35.1%) were female. Of the children, 426 (84.5%) had no evidence of injury or minor injury, while 78 (15.5%) had moderate or severe injury. There was a statistically significant difference between these two groups in terms of gender ( p = 0.031). Of the 78 children with moderate or severe injuries, 45 had extremity fractures, 18 had lacerations, 5 had maxillofacial injuries, 4 had cerebral contusion, 1 had lung contusion, and 1 had cervical soft-tissue damage. Two patients with fractures and two with eyelid lacerations were treated surgically, and four patients with brain contusion were hospitalized for a close follow-up. Conclusion This study revealed that the most common moderate or severe injuries in school accidents referred to emergency department were distal radius fractures and lacerations

Prediction of Undrained Shear Strength by the GMDH-Type Neural Network Using SPT-Value and Soil Physical Properties

This study presents a novel method for predicting the undrained shear strength (c(u)) using artificial intelligence technology. The c(u) value is critical in geotechnical applications and difficult to directly determine without laboratory tests. The group method of data handling (GMDH)-type neural network (NN) was utilized for the prediction of c(u). The GMDH-type NN models were designed with various combinations of input parameters. In the prediction, the effective stress (sigma(v)'), standard penetration test result (N-SPT), liquid limit (LL), plastic limit (PL), and plasticity index (PI) were used as input parameters in the design of the prediction models. In addition, the GMDH-type NN models were compared with the most commonly used method (i.e., linear regression) and other regression models such as random forest (RF) and support vector regression (SVR) models as comparative methods. In order to evaluate each model, the correlation coefficient (R-2), mean absolute error (MAE), and root mean square error (RMSE) were calculated for different input parameter combinations. The most effective model, the GMDH-type NN with input parameters (e.g., sigma(v)', N-SPT, LL, PL, PI), had a higher correlation coefficient (R-2 = 0.83) and lower error rates (MAE = 14.64 and RMSE = 22.74) than other methods used in the prediction of c(u) value. Furthermore, the impact of input variables on the model output was investigated using the SHAP (SHApley Additive ExPlanations) technique based on the extreme gradient boosting (XGBoost) ensemble learning algorithm. The results demonstrated that using the GMDH-type NN is an efficient method in obtaining a new empirical mathematical model to provide a reliable prediction of the undrained shear strength of soils.Chungnam National University; National Research Foundation of Korea (NRF) - Korea government (MSIT) [NRF2022R1C1C1011477]This work was supported by research fund of Chungnam National University and National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. NRF2022R1C1C1011477)

Association of adipokines, insulin resistance, hypertension and dyslipidemia in patients with psoriasis vulgaris

Background: Systemic inflammation in psoriasis causes insulin resistance and cardiovascular diseases. Adipokines are adipose-tissue-derived factors that are involved in metabolic processes. It is thought that these adipokines are associated with the development of psoriasis. Objective: The purpose of this study was to determine the changes in adipokine levels, insulin resistance, hypertension, and dyslipidemia over a 12-week period. Methods: The study comprised 35 psoriasis patients and 50 controls. Blood samples were obtained twice from the patients, one sample at the start and one at the end of a 12-week follow-up period. The following parameters were assessed in both groups: serum fasting glucose, fasting insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, serum lipids, adiponectin, leptin, resistin, chemerin, omentin, vaspin, visfatin, retinol-binding protein 4, and high-sensitivity C-reactive protein (hs-CRP) levels; blood pressure; body mass index; and the psoriasis area severity index (PASI) scores. Results: The patients showed an improvement in the PASI score and a significant decrease in serum hs-CRP, omentin, and chemerin values. Moreover, at the start of the follow-up, the psoriasis patients had significantly lower levels of adiponectin and visfatin and significantly higher levels of vaspin and resistin than those of the control group. Visfatin levels correlated negatively with low-density lipoprotein (LDL) and cholesterol, while vaspin and omentin levels correlated positively with diastolic blood pressure. Decreased adiponectin levels correlated negatively with diastolic blood pressure and LDL. Conclusion: Plasma levels of adipokines might be useful for evaluating the disease activity of psoriasis and its comorbidities

Leptin receptor gene polymorphism may affect subclinical atherosclerosis in patients with acromegaly

Background: Acromegaly is associated with increased morbidity and mortality related to cardiovascular diseases. Leptin (LEP) and Leptin Receptor (LEPR) gene polymorphisms can increase cardiovascular risks. The aim of this study was to investigate association between the frequencies of LEP and LEPR gene polymorphisms and subclinical atherosclerosis in acromegalic patients. Methods: Forty-four acromegalic patients and 30 controls were admitted to study. The polymorphisms were identified by using polymerase chain reaction from peripheral blood samples. The levels of systolic and diastolic blood pressure, BMI, fasting plasma glucose, fasting insulin, IGF-I, GH, IGFBP3, leptin, triglyceride, carotid Intima Media Thickness (cIMT) and HDL and LDL cholesterol concentrations were evaluated. Results: There was statistically significant difference between the LEPR genotypes of acromegalic patients (GG 11.4%, GA 52.3%, and AA 36.4%) and controls (GG 33.3%, GA 50%, and AA 16.7%) although their LEP genotype distribution was similar. In addition, the prevalence of the LEPR gene G and A alleles was significantly different between patients and controls. No significant difference was found among the G(-2548) A leptin genotypes of groups in terms of the clinical parameters. cIMT significantly increased homozygote LEPR GG genotype group compared to AA subjects in patients. But the other parameters were not different between LEPR genotypes groups of patients and controls. Conclusion: It can be said that the LEPR gene polymorphism may affect cIMT in patients. The reason is that LEPR GG genotype carriers may have more risk than other genotypes in the development of subclinical atherosclerosis in acromegaly. © 2016, Avicenna Journal of Medical Biotechnology. All rights reserved

Growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) gene polymorphisms in Turkish native cattle breeds

The aim of this study was to determine the genetic diversity of 4 native Turkish cattle breeds, based on the growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) genes. In order to study the polymorphisms in these genes, the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method was performed. A 329-bp fragment and a 223-bp fragment of GH, a 156-bp fragment of PRL, and a 411-bp fragment of DGAT1, thus 4 loci of 3 genes, were amplified via PCR. These fragments were then restricted with the enzymes MspI, Alu1, RsaI, and CfrI, respectively. In this study, 2 types of alleles, (+) and (-) for the GH-MspI, L and V for the GH-Alu1, A and B for the PRL, and K and A for the DGAT1 loci, were observed. The results of the present study will contribute to the polymorphism data on the world's cattle breeds. Furthermore, the above-mentioned allele frequencies of Turkish native breeds are evaluated in relation to their genetic relatedness, and to infer their milk production properties on the basis of the available literature. In turn, these results can be utilized for future breeding programs of dairy cattle in Turkey

Leptin Receptor Gene Polymorphism may Affect Subclinical Atherosclerosis in Patients with Acromegaly

Abstract Background: Acromegaly is associated with increased morbidity and mortality related to cardiovascular diseases. Leptin (LEP) and Leptin Receptor (LEPR) gene polymorphisms can increase cardiovascular risks. The aim of this study was to investigate association between the frequencies of LEP and LEPR gene polymorphisms and subclinical atherosclerosis in acromegalic patients. Methods: Forty-four acromegalic patients and 30 controls were admitted to study. The polymorphisms were identified by using polymerase chain reaction from peripheral blood samples. The levels of systolic and diastolic blood pressure, BMI, fasting plasma glucose, fasting insulin, IGF-I, GH, IGFBP3, leptin, triglyceride, carotid Intima Media Thickness (cIMT) and HDL and LDL cholesterol concentrations were evaluated. Results: There was statistically significant difference between the LEPR genotypes of acromegalic patients (GG 11.4%, GA 52.3%, and AA 36.4%) and controls (GG 33.3%, GA 50%, and AA 16.7%) although their LEP genotype distribution was similar. In addition, the prevalence of the LEPR gene G and A alleles was significantly different between patients and controls. No significant difference was found among the G(-2548) A leptin genotypes of groups in terms of the clinical parameters. cIMT significantly increased homozygote LEPR GG genotype group compared to AA subjects in patients. But the other parameters were not different between LEPR genotypes groups of patients and controls. Conclusion: It can be said that the LEPR gene polymorphism may affect cIMT in patients. The reason is that LEPR GG genotype carriers may have more risk than other genotypes in the development of subclinical atherosclerosis in acromegaly

Hypertension Awareness İn Namik Kemal University Faculty Of Medicine Students And Employees

Hipertansiyon (HT) tüm dünyada ve Türkiye’de yaygın görülen bir hastalıktır. Türkiye’de HT prevelansı % 31.8’dir. HT aynı zamanda önemli hayati organları etkileyen, önemli morbidite ve mortaliteye yol açan, maliyeti yüksek bir hastalıktır. HT’un belki de en önemli özelliği semptomlarının silik olması nedeniyle farkındalığının düşük olmasıdır. Türk Hipertansiyon ve Böbrek Hastalıkları derneği tarafından yapılan HT prevelans çalışmasında, Türkiye’de HT farkındalığı %40 olarak saptanırken, Hipertansif bireylerin % 31’inin antihipertansif tedavi aldığı ve % 8’inin kan basıncının (KB) kontrol altında olduğu saptanmıştır. Biz çalışmamızda Tıp fakültesi öğrencileri ve çalışanları arasındaki HT farkındalığını değerlendirmeyi amaçladık.Hypertension (HT) is a common disease worldwide and in Turkey. The prevalence of HT in Turkey is 31.8%. HT is also a costly disease that affects important vital organs, leading to significant morbidity and mortality. The most important feature of HT is its low awareness because of its symptoms are faint. In the HT prevalence study conducted by the Turkish Hypertension and Kidney Disease Association, HT awareness was determined as 40%, 31% of the hypertensive individuals used antihypertensive medications and 8% of them were under control of blood pressure (BP). In our study, we aimed to evaluate HT awareness among medical faculty students and employee

Hypertension Awareness in Namik Kemal University Faculty of Medicine Students And Employees

Aim:Hypertension (HT) is a common disease worldwide and in Turkey. The prevalence of HT in Turkey is 31.8%. HT is also a costly disease that affects important vital organs, leading to significant morbidity and mortality. The most important feature of HT is its low awareness because of its symptoms are faint. In the HT prevalence study conducted by the Turkish Hypertension and Kidney Disease Association, HT awareness was determined as 40%, 31% of the hypertensive individuals used antihypertensive medications and 8% of them were under control of blood pressure (BP). In our study, we aimed to evaluate HT awareness among medical faculty students and employees.Material and Methods:A number of questions were asked to the employees and students in order to evaluate the knowledge of HT. Our question briefly; Is there HT in the family, have you ever done the BP measurement, where did you get the BP measurement, Do you have a BP measurement device at home, do you know the brand name of the BP measuring device? ın which case the BP measurement should be made, do you know about the HT frequency, Do you know the effects of HT, If you have HT and you are taking antihypertensive medications. After the questionnaire forms were completed, the data were analyzed.Results:A total of 456 people responded to the survey questions. The average age of the participants was 21.49 ± 4.10 (39.5% female) while 85.5% were university students. 45% in family with HT, 67.5% had a BP measurement, 42.8% had BP measurements in the hospital, 47.4% had the BP measuring device at home, 11.8% indicated that the measurement was performed routinely without any symptoms, 27% have knowledge about HT frequency , 45.8% had knowledge of HT effects, while 54 of those with high BP were receiving antihypertensive treatment. In the logistic regression analysis, those who had HT in the family, had a home BP measuring device, had information about the HT frequency, and knew the effects of HT were determined as parameters affecting the BP measurement.Conclusion:For the first time in our work, we evaluated HT awareness in NKU Medical faculty students and employees. We have found that our knowledge of HT frequency and effectiveness is very low. We think that awareness should be increased with training meetings

Preliminary results of the Sofalaca-Şehitkamil Gaziantep (Mw:7.7) and Ekinözü Kahramanmaraş (Mw:7.6) earthquakes based on GNSS observations on February 6, 2023

Bu çalışmada 6 Şubat 2023 tarihinde sırasıyla yerel saat ile 04:17 ve 13:24’te artarda meydana gelen Sofalaca-Şehitkamil Gaziantep (Mw:7.7) ve Ekinözü Kahramanmaraş (Mw:7.6) depremlerinin öncül jeodezik sonuçları verilmiştir. Öncül jeodezik sonuçları elde etmek için deprem odak merkezleri etrafındaki ve etkili olduğu alandaki TUSAGA-Aktif istasyonlarına ait GNSS alıcılarından 30 sn (0,033 Hz) ve 1 sn’lik (1 Hz) GNSS gözlemleri kullanılmıştır. Deprem kaynaklı kosismik yer değiştirmeleri belirlemek için bağıl statik çözümler GAMIT/GLOBK yazılım takımında 30 sn’lik RINEX verileri kullanılarak yapılmıştır. Statik çözümlerde değerlendirmeye alınan istasyonlarda Sofalaca-Şehitkamil Gaziantep depreminde doğu bileşende atımın 1.1-23.4 cm, kuzey bileşende 1.1-30.9 cm aralığında değiştiği görülmüştür. Ekinözü Kahramanmaraş depreminde ise atım miktarı doğu bileşende 1.2-440.4 cm, kuzey bileşende 1.4-69.6 cm aralığında değişmiştir. Kinematik çözümler ise PPP yöntemiyle CSRS-PPP ve PRIDE PPP-AR yazılımları ile 1 sn’lik RINEX verileri kullanılarak elde edilmiştir. Her iki yazılımda seçilen istasyonlardaki deprem anı yer değiştirmeler (deplasman) ve ardışık epok farkları (hız) hesaplanmıştır. Seçilen tüm istasyonlarda hızlar Sofalaca-Şehitkamil Gaziantep depreminde doğu bileşen için 3-12.5 cm/sn, kuzey bileşen için 3.8 - 37.7 cm/sn aralığında; Ekinözü Kahramanmaraş depreminde ise doğu bileşende 3.7-20.5 cm/sn, kuzey bileşende 4.1-20.1 cm/sn tespit edilmiştir. Öncül sonuçların elde edilmesinden sonra bölgenin daha yakından takibi ve yeni noktalarda atımların tespiti için yeni bir GNSS ağı kurulmuştur. Kurulan yeni ağda TÜBİTAK 1002-C Doğal Afetler Odaklı Saha Çalışması Acil Destek Programı çağrısı kapsamında arazi çalışmalarına başlanmıştır.In this study, the earthquakes which took place on 6 February 2023, respectively at local time 04:17 and 13:24 preliminary geodetic results are given that occurred of Sofalaca-Şehitkamil (Gaziantep) (Mw:7.7) and of Ekinözü (Kahramanmaraş) (Mw: 7.6). In order to obtain preliminary geodetic results the GNSS observations were used at 30 s (0.033 Hz) and 1 s (1 Hz) intervals from the GNSS receivers in the network of Continuously Operating Reference Stations, Turkey (CORS-TR). Relative static solutions to determine earthquake-induced coseismic displacements were performed using 30-second RINEX data in the GAMIT/GLOBK software. In the GNSS stations evaluated in the static solutions, it was observed that the coseismic displacement in the Sofalaca-Şehitkamil Gaziantep earthquake varied between 1.1 - 23.4 cm in the eastern component and 1.1 - 30.9 cm and northern component. In the Ekinözü Kahramanmaraş earthquake, the amount of coseismic displacement varied between 1.2 - 440.4 cm in the eastern component and 1.4-69.6 cm in the northern component. Kinematic solutions were obtained by PPP method using CSRS-PPP and PRIDE PPP-AR software and 1 second RINEX data. In both software, earthquake displacements and consecutive epoch differences (velocity) at selected stations were calculated.During the Sofalaca Şehitkamil-Gaziantep earthquake velocities for all selected stations were detected approximately between 3.0-12.5 cm/s for the eastern component and 3.8 - 37.7 cm/sn for the northern component; during the Ekinözü Kahramanmaraş earthquake were detected approximately between 3.7-20.5 cm/sn for the eastern component and 4.1-20.1 cm/sn for the northern component. After the preliminary results were obtained, a new GNSS network was established to observation the region more closely and to detect displacement at new GNSS points. In study area has started new GNSS observations within the scope of TÜBİTAK 1002-C Natural Disasters Focused Field Study Emergency Support Program call in the new network established

Investigation of synthesis, characterization, dielectric, electrokinetic and electrorheological properties of poly(3-aminophenylboronic acid)

İletken polimerlerin dikkat çekici optik ve elektronik özelliklerinin yanı sıra, borik asit türevleriyle birleşerek, daha dayanıklı ve işlevsel malzeme üretiminde kullanımları son yıllarda oldukça dikkat çekmektedir. Bu çalışmada yarı iletken malzeme özelliği gösteren ve geliştirilmiş kolloidal ve elektroreolojik özellikler sağlayabileceği öngörülen poli(3-aminofenilboronik asit) (PABA) polimeri sentezlendi. PABA'nın yapısal, morfolojik ve yüzey karakterizasyonları element analizi, ATR-FTIR, X-ışınları kırınımı (XRD), termogravimetrik analiz (TGA), taramalı elektron mikroskobu (SEM), geçirimli elektron mikroskobu (TEM), yoğunluk, iletkenlik ve temas açısı ölçümleri ile gerçekleştirildi. PABA taneciklerin dinamik ışık saçılımı (DLS) ile hidrodinamik ortalama tanecik büyüklükleri 254 nm olarak belirlendi. PABA(aq) dispersiyonların elektrokinetik özellikleri zeta()-potansiyeli ölçümleri ile çeşitli elektrolit ortamlarında araştırıldı. PABA'nın silikon yağı (SO) içerisinde, %1,25 Triton-X içerecek şekilde, %5 hacim kesrinde, ( = %5V/V) dispersiyonları hazırlandı. Hazırlanan dispersiyonların dielektrik özellikleri LCR metre ile ölçüldü. PABA/SO/Triton-X dispersiyonların yer çekimine karşı çökelmeme kararlılığı oranının %100 olduğu tespit edildi. Dispersiyonların uygulanan dış elektrik alan kuvveti altında polarlanabilirliği optik mikroskop ile gözlendi. PABA/SO/Triton-X dispersiyonların elektroreolojik (ER) akış davranışları üzerine kayma hızı, kayma gerilimi, elektrik alan kuvveti ve sıcaklık gibi farklı parametrelerin etkisi elektroreometre ile incelendi ve Newtonian olmayan kayma incelmesi türünden viskoelastik akış davranışı gözlendi. PABA/SO/Triton-X dispersiyonların elastik modülü üzerine kayma gerilimi, frekans ve zamanın etkisi viskoelastik ölçümler ile incelenerek malzemelerin titreşim sönümleme özelliklerinin olduğu tespit edildi. Ayrıca PABA/SO/Triton-X dispersiyonlara sürünme-geri kazanım testleri uygulandı ve tersinir viskoelastik deformasyon gösterdikleri belirlendi.In recent years, conducting polymers, besides their remarkable optical and electronic properties, have been used for the production of durable and functional materials by combining with boric acid derivatives. In this study, semiconducting poly(3-aminophenylboronic acid), PABA was synthesized with the expectations of enhanced colloidal and electrorheological properties. Structural, morphological and surface characterizations of PABA was carried out by elemental analysis, ATR-FTIR spectroscopy, X-Ray Diffraction analysis, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, density, conductivity and contact angle measurements. Average hydrodynamic particle size of PABA particles was measured to be 254 nm by dynamic light scattering. Electrokinetic properties of PABA(aq) dispersions were determined by zeta()-potantial measurements in various electrolyte media. Then, PABA/silicone oil (SO) dispersions, containing 1.25% Triton-X, were prepared with 5% volume fraction. Dielectric properties of PABA/SO/Triton-X dispersions were determined by an LCR meter. Antisedimentation stability of PABA/SO/Triton-X dispersion was determined to be 100%. Polarizabilitiy of PABA/SO dispersion was observed under an optical microscope. Electrorheological flow behaviors of PABA/SO/Triton-X dispersions were determined by taking the effects of shear rate, shear stress, electric field strength and temperature using an electrorheometer. Non-Newtonian shear thinning flow behavior was determined for PABA/SO/Triton-X dispersions. Vibration damping capabilities of PABA/SO/Triton-X dispersions were investigating by measuring their elastic and viscous modulus as functions of frequency and, time and electric field strengths. Creep and creep-recovery tests were also applied to PABA/SO/Triton-X dispersions and reversible viscoelastic deformations observed. Due to these properties PABA/SO/Triton-X dispersions were classified as smart materials and suggested as a good candidate for potential industrial vibration damping applications