6.Sınıf “Kuvvet ve Hareket” Ünitesinde Basamaklı Öğretim Yöntemi ve Yaratıcı Drama Yönteminin Erişiye, Tutuma ve Kalıcılığa Etkisi

The purpose of this study was to compare layered curriculum and creative drama methods on ‘Force and Motion’ unit of Science and Technology at 6th grade course, for the academic achievement, attitude towards Science and Technology courses and the effects of retention of knowledge; and to determine which method is more effective experimentally. The other aim of this study was to reveal students’ opinions related to both methods. In this sense, mixed method strategy with combination of quantitative and qualitative data was used in this study.The research was conducted on 44 students who were attending on 6th classrooms in a primary school placed in south Antalya, in 2011-2012 academic year. In this study, one experimental and one comparison group was constructed. The subjects were taught with creative drama method in I. and with layered curriculum method in II. comparison group. In this research, the quantitative data was collected by using achievement test, the attitude scale and learning scale inventory; qualitative data was collected by using observation forms, process evaluation and semi-structured interviews. Data were collected on both quantitative and qualitative methods , and analyzed by using SPSS program (frequency and percentage calculations, ANCOVA) and qualitative analysis method (coding, thematization) respectively.According to results of the study, both of creative drama and layered curriculum methods have positive effects on academic achievement and retention of knowledge. It was determined that the academic achievement of experimental group of creative drama was higher than the comparison group of layered curriculum. However, it was concluded that both of these methods hadn’t any statistically significant effect on the students attitude towards Science and Technology course, it had seen an significant increase in interest of students, according to information obtained from qualitative data collection tools.Çalışmanın amacı; ilköğretim 6. sınıf Fen ve Teknoloji dersi “Kuvvet ve Hareket” ünitesinde basamaklı öğretim yöntemi ile yaratıcı drama yönteminin, akademik başarıya, fen ve teknoloji dersine karşı tutumuna ve başarı üzerinde kalıcılığa etkilerini araştırmak ve yöntemlerin etkililiğini deneysel yolla sınamaktır. Bu çalışmada ayrıca öğrencilerin her iki yöntemle ilgili görüşleri de ortaya çıkarılmaya çalışılmıştır. Bu anlamda bu çalışmada nicel ve nitel verilerin bir arada yer aldığı karma yöntem kullanılmıştır.Araştırma 2011-2012 eğitim-öğretim yılında Antalya ilinin güneyinde yer alan bir ilçede 6. sınıfta okumakta olan toplam 44 öğrenci üzerinde yürütülmüştür. Bu çalışmada biri deney biri karşılaştırma grubu olarak iki grup seçilmiştir. Konular I. deney grubunda yaratıcı drama yöntemiyle, II. karşılaştırma grubunda ise basamaklı öğretim yöntemi ile işlenmiştir. Araştırmada nicel veriler başarı testi, tutum ölçeği ve öğrenme stili ölçeğiyle; nitel veriler ise öğrenci günlükleri, gözlem formu, süreç değerlendirmeleri ve yarı yapılandırılmış görüşmelerle toplanmıştır. Araştırmada elde edilen nicel veriler SPSS programı kullanılarak (frekans ve yüzde hesapları, ANCOVA), nitel veriler ise nitel analiz yöntemleri kullanılarak (kodlama, temalama) analiz edilmiştir.Araştırma sonuçlarına göre; hem yaratıcı drama yöntemi hem de basamaklı öğretim yönteminin, öğrencilerin akademik başarılarını ve başarı üzerinde kalıcılıklarını olumlu yönde etkilediği görülmüştür. Bununla birlikte yaratıcı drama yönteminin uygulandığı deney grubunun akademik başarısı, basamaklı öğretim yönteminin uygulandığı karşılaştırma grubuna göre daha yüksek olduğu bulunmuştur. Uygulanan her iki yöntemin de, öğrencilerin Fen ve Teknoloji Dersine yönelik tutumları üzerinde istatistiksel anlamda artış görülmemesine karşın, nitel veri toplama araçlarından elde edilen bilgilere göre ilgilerinin arttığı görülmüştür. Nicel ve nitel veriler arasındaki bu farklılığın, uygulama süresinin kısa ve örneklem sayısının az olmasından kaynaklandığı söylenebilir

Evidence of association of vitamin D receptor Apa I gene polymorphism with bone mineral density in postmenopausal women with osteoporosis

The vitamin D receptor (VDR) was the firstcandidate gene to be studied in relation to osteoporosis, andmost attention has focused on polymorphisms situated nearthe 3' flank of VDR. The aim of this study was toinvestigate the association about VDR gene Apa I polymorphismwith bone mineral density (BMD) in postmenopausalwomen with osteoporosis. We studied a total of 136postmenopausal women with a mean age of 56.36±10.29 years. Among them, a total of 75 had osteoporosis,37 had osteopenia, and 24 had normal BMD. Venous bloodsamples were obtained for evaluation of bone metabolismand genotyping. The VDR Apa I genotype was determinedby polymerase chain reaction-restriction fragment lengthpolymorphism. BMDs at the lumbar spine and hip weremeasured by dual-energy X-ray absorptiometry. Postmenopausalwomen with aa genotype had significantly lowerBMD values (grams per centimeter square) at lumbar spinescompared to persons with AA genotype. Also, postmenopausalwomen with AA genotype had significantly higherserum Ca level than the subjects with aa genotype. Inconclusion, our result may indicate that VDR Apa I genepolymorphism may be responsible for a important part ofthe heritable component of lumbar spine BMD in postmenopausalwomen, possibly related to impaired calciumabsorption from the bowel

Metachronous Bilateral Adenoid Cystic Carcinoma of the Lacrimal Gland

Background: To report an aggressive and treatment-resistant adenoid cystic carcinoma (ACC) of the lacrimal gland (LG).Case report: A 29-year-old woman with diagnosis of LG-ACC had operations 7 times, radiotherapy 3 times and systemic chemotherapy 2 times. Although she generally responded therapies, the duration of remissions was short lived and the tumor progressed locally and did hematogen metastases.Conclusion: LG-ACC presents a therapeutic challenge despite its slow growth rate and lower likelihood of lymph-node metastasis. Postoperative radiotherapy with wide margins should be utilized —even after a complete resection— because of persistent recurrences, perineural invasion and hematogenous spread.

Comparison of the Early Results of Preterm Infants who Underwent the Surgical Ligation of Patent Ductus Arteriosus with two Different Surgical Approaches

INTRODUCTION: Patent ductus arteriosus (PDA) is the most common congenital heart disease in preterm infants. Surgical ligation is still the gold standard technique, especially in low birth weight patients. To reduce surgical trauma and possible complications, the anterior mini-thoracotomy (AMT) technique has been defined. However, conventional lateral thoracotomy (LT) is still the method preferred by many centers today. In our study, we aimed to compare the early results of preterm infants who underwent PDA ligation with two different surgical techniques in a newly established center. METHODS: A total of 26 patients (12 males, 14 females; median gestational age at surgery 32 weeks [IQR: 29-37]) who underwent surgical PDA ligation in preterm infants between January 2018 and February 2020 were retrospectively analyzed. PDA closure was performed through the left anterior mini-thoracotomy approach in 15 of the patients and left lateral thoracotomy in 11 patients. The early outcomes of the two groups were compared. RESULTS: The median weight at operation was 1000 gr. (IQR: 720-1200) in AMT group and 1200 gr. (IQR: 1000 – 2800) in the LT group. The difference between weights at operation was found statistically significant (p: 0.03). The operation time of the AMT group was found to be statistically significantly shorter. (p: 0.03) DISCUSSION AND CONCLUSION: Anterior mini-thoracotomy technique provides an effective surgical closure in the low-weight preterm infant at least lateral thoracotomy technique. Based on the results of our series and our opinion, it should be considered the first choice surgical method, especially in very low and extremely low-weight preterm infants

Analysis of proliferative activity in oral gingival epithelium in immunosuppressive medication induced gingival overgrowth

BACKGROUND: Drug-induced gingival overgrowth is a frequent adverse effect associated principally with administration of the immunosuppressive drug cyclosporin A and also certain antiepileptic and antihypertensive drugs. It is characterized by a marked increase in the thickness of the epithelial layer and accumulation of excessive amounts of connective tissue. The mechanism by which the drugs cause gingival overgrowth is not yet understood. The purpose of this study was to compare proliferative activity of normal human gingiva and in cyclosporine A-induced gingival overgrowth. METHODS: Gingival samples were collected from 12 generally healthy individuals and 22 Cyclosporin A-medicated renal transplant recipients. Expression of proliferating cell nuclear antigen was evaluated in formalin-fixed, paraffin-embedded gingival samples using an immunoperoxidase technique and a monoclonal antibody for this antigen. RESULTS: There were differences between the Cyclosporin A group and control group in regard to proliferating cell nuclear antigen and epithelial thickness. In addition, the degree of stromal inflammation was higher in the Cyclosporin A group when compared with the control group. CONCLUSION: The results suggest that the increased epithelial thickness observed in Cyclosporin A-induced gingival overgrowth is associated with increased proliferative activity in keratinocytes

Expression of caspase-3, p53 and Bcl-2 in generalized aggressive periodontitis

BACKGROUND: Apoptosis, or programmed cell death is a form of physiological cell death. It is increased or decreased in the presence of infection, inflammation or tissue remodelling. Previous studies suggest that apoptosis is involved in the pathogenesis of inflammatory periodontal disease. The aim of the present study was to investigate the clinical features and known indicators of apoptosis (p53, Bcl-2, Caspase-3) in patients with generalized aggressive periodontitis (GAP) METHODS: Eight patients with GAP, who had sites with probing depths (PD) > 5 mm, and 10 periodontally-healthy persons were included in the study. Clinical examinations and PD were performed, and the plaque index and gingival index were recorded. Gingival tissues biopsies were obtained from active site of each patient and from healthy individuals. The expression of caspase-3, Bcl-2, and p53 was evaluated by immunohistochemistry RESULTS: There were no significant differences between GAP and control group with respect to levels of caspase-3 and p53 expression (P > 0.05). Contrary, the frequency of grade 3 expression of Bcl-2 was higher in GAP group than the control group. CONCLUSION: The higher frequency of Bcl-2 expression in GAP group indicates and delayed apoptosis can lead to increasing resident inflammatory cells in periodontal tissues and resulting in progressive periodontal destruction

Characteristics of food allergy in children: National multicenter study

Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) Location: Lisbon, PORTUGAL Date: JUN 01-05, 2019Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.European Academy of Allergy and Clinical Immunolog

Self-reported antibiotic stewardship and infection control measures from 57 intensive care units: An international ID-IRI survey

We explored the self-reported antibiotic stewardship (AS), and infection prevention and control (IPC) activities in intensive care units (ICUs) of different income settings. A cross-sectional study was conducted using an online questionnaire to collect data about IPC and AS measures in participating ICUs. The study participants were Infectious Diseases-International Research Initiative (IDI-IR) members, committed as per their institutional agreement form. We analyzed responses from 57 ICUs in 24 countries (Lower-middle income (LMI), n = 13; Upper-middle income (UMI), n = 33; High-income (HI), n = 11). This represented (similar to 5%) of centers represented in the ID-IRI. Surveillance programs were implemented in (76.9%-90.9%) of ICUs with fewer contact precaution measures in LMI ones (p = 0.02); (LMI:69.2%, UMI:97%, HI:100%). Participation in regional antimicrobial resistance programs was more significantly applied in HI (p = 0.02) (LMI:38.4%,UMI:81.8%,HI:72.2%). AS programs are implemented in 77.2% of institutions with AS champions in 66.7%. Infectious diseases physicians and microbiologists are members of many AS teams (59%&50%) respectively. Unqualified healthcare professionals(42.1%), and deficient incentives(28.1%) are the main barriers to implementing AS. We underscore the existing differences in IPC and AS programs' implementation, team composition, and faced barriers. Continuous collaboration and sharing best practices on APM is needed. The role of regional and international organizations should be encouraged. Global support for capacity building of healthcare practitioners is warranted. (C) 2022 Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences

Hemşirelik Öğrencilerinin Uyku Hijyeni Öğretimini Etkileyen Faktörler

Objective: As a part of their clinical practice curriculum, nursing students are expected to provide sleep hygiene (SH) training to their patients. It is important to determine the factors that affect this training program. We aimed to examine the nursing students’ condition of delivering SH training to their patients as well as the relationship between the training program and the students’ SH behaviors, knowledge of sleep, and attitude toward the training program.Materials and Methods: A total of 259 nursing students in their second year of bachelor’s degree education participated in this study. The data were gathered by using the Individual Identification Form, SH index, Sleep Knowledge Assessment form, and Attitude Towards SH Training form.Results: Based on analysis of the data gathered from the forms, all students reported having received SH training and 80.3% of them admitted to delivering the training to their patients. Logistic regression analysis of the data revealed that SH (Wald ?2=7.01, p=0.008), knowledge of sleep (Wald ?2=15.63, p<0.001), and the attitude toward SH training (Wald ?2=36.29, p<0.001) are important determinants of SH training. Conclusion: The results of this study suggest that better sleep hygiene, enhanced information on sleep, and more positive attitude toward SH training increases the likelihood of successful delivery of SH training to patients.Amaç: Klinik uygulamada, hemşirelik öğrencilerinden hastalarına uyku hijyeni (UH) eğitimi vermeleri beklenmektedir. Burada öğrencinin hastaya yönelik yaptığı UH öğretimini etkileyen faktörlerin ne olduğunun belirlenmesi önemlidir. Araştırmanın amacı, hemşirelik öğrencilerinin hastalarına UH eğitimi verme durumu ve UH öğretimi ile UH davranışı, uyku bilgisi ve UH öğretimine ilişkin tutumları arasındaki ilişkiyi incelemektir. Gereç ve Yöntem: Araştırma ikinci sınıfta öğrenim gören 259 hemşirelik öğrencisi ile yürütüldü. Veriler, Birey Tanıtım Formu, UH indeksi, Uyku Bilgisi Değerlendirme formu ve UH Öğretimine Yönelik Tutum formu kullanılarak toplandı. Bulgular: Öğrencilerin tamamı UH ile ilgili eğitim aldıklarını ve %80,3’ü hastalarına uyku eğitimi verdiğini belirtmiştir. Lojistik regresyon analizi sonuçlarına göre, UH (Wald ?2=8,07, p=0,004), uyku bilgisi (Wald ?2=43,24, p=0,000) ve UH öğretimine yönelik tutum (Wald ?2=7,24, p=0,007) UH öğretiminin önemli belirleyicileri olduğu bulunmuştur. Sonuç: Araştırma sonucunda, daha iyi UH, uyku hakkında daha fazla bilgi ve UH öğretimine yönelik daha olumlu tutumların hastalara UH öğretimi verme olasılığını arttırdığı saptanmıştır