Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice

Sulfonylureas are a class of antidiabetes medications prescribed to millions of individuals worldwide. Rodents have been used extensively to study sulfonylureas in the laboratory. Here, we report the results of studies treating mice with a sulfonylurea (glimepiride) in order to understand how the drug affects glucose homeostasis and tolerance. We tested the effect of glimepiride on fasting blood glucose, glucose tolerance, and insulin secretion, using glimepiride sourced from a local pharmacy. We also examined the effect on glucagon, gluconeogenesis, and insulin sensitivity. Unexpectedly, glimepiride exposure in mice was associated with fasting hyperglycemia, glucose intolerance, and decreased insulin. There was no change in circulating glucagon levels or gluconeogenesis. The effect was dose-dependent, took effect by two weeks, and was reversed within three weeks after removal. Glimepiride elicited the same effects in all strains evaluated: four wild-type strains, as well as the transgenic Grn−/− and diabetic db/db mice. Our findings suggest that the use of glimepiride as a hypoglycemic agent in mice should proceed with caution and may have broader implications about mouse models as a proxy to study the human pharmacopeia

Higgsless electroweak symmetry breaking at the LHC

While the Higgs model is the best studied scenario of electroweak symmetry breaking, a number strongly-coupled models exist, predicting new signatures. Recent studies of WW and WZ final states at the ATLAS and CMS experiments are summarized and expected sensitivities are presented within the frameworks of the technicolor straw-man model and the electroweak chiral Lagrangian.Comment: Proceedings for the EPS HEP 2007 conference, Manchester, U.K., on behalf of the ATLAS and CMS Collaboration

Symmetric Teleparallel Gravity: Some exact solutions and spinor couplings

In this paper we elaborate on the symmetric teleparallel gravity (STPG) written in a non-Riemannian spacetime with nonzero nonmetricity, but zero torsion and zero curvature. Firstly we give a prescription for obtaining the nonmetricity from the metric in a peculiar gauge. Then we state that under a novel prescription of parallel transportation of a tangent vector in this non-Riemannian geometry the autoparallel curves coincides with those of the Riemannian spacetimes. Subsequently we represent the symmetric teleparallel theory of gravity by the most general quadratic and parity conserving lagrangian with lagrange multipliers for vanishing torsion and curvature. We show that our lagrangian is equivalent to the Einstein-Hilbert lagrangian for certain values of coupling coefficients. Thus we arrive at calculating the field equations via independent variations. Then we obtain in turn conformal, spherically symmetric static, cosmological and pp-wave solutions exactly. Finally we discuss a minimal coupling of a spin-1/2 field to STPG.Comment: Accepted for publication in the International Journal of Modern Physics

Dirac field in topologically massive gravity

We consider a Dirac field coupled minimally to the Mielke-Baekler model of gravity and investigate cosmological solutions in three dimensions. We arrive at a family of solutions which exists even in the limit of vanishing cosmological constant.Comment: 12 pages. Title changed. Conclusion extended. Appendix added. To appear in Gen. Rel. Gra

A stochastic local search algorithm with adaptive acceptance for high-school timetabling

Automating high school timetabling is a challenging task. This problem is a well known hard computational problem which has been of interest to practitioners as well as researchers. High schools need to timetable their regular activities once per year, or even more frequently. The exact solvers might fail to find a solution for a given instance of the problem. A selection hyper-heuristic can be defined as an easy-to-implement, easy-to-maintain and effective 'heuristic to choose heuristics' to solve such computationally hard problems. This paper describes the approach of the team hyper-heuristic search strategies and timetabling (HySST) to high school timetabling which competed in all three rounds of the third international timetabling competition. HySST generated the best new solutions for three given instances in Round 1 and gained the second place in Rounds 2 and 3. It achieved this by using a fairly standard stochastic search method but significantly enhanced by a selection hyper-heuristic with an adaptive acceptance mechanism. © 2014 Springer Science+Business Media New York

Short communication: Serranus cabrilla (Linnaeus, 1758) (Perciformes, Serranidae) a new host record for Nerocila orbigyni (Guérin-Mèneville, 1832) (Isopoda, Cymothoidae)

Cymothoids are among the largest parasites of fishes in the world. These isopods associate with many commercially important fish species and attach themselves to the body or fins of the fishes. The isopods cause significant economic losses to fisheries by killing, stunting, or damaging these fishes. ... The serranid fish, Serranus cabrilla (Linnaeus, 1758) (the comber) is a commercial species and has a wide distribution (north Atlantic Sea [sic], North Sea and Mediterranean Sea). The comber is a demersal species found on rocks, and on sandy and muddy bottoms at depths of 1-500 [meters]. This is the main species captured by trawlers fishing in the Aegean Sea of the Turkish coast. N. orbignyi has been determined for the first time on S. cabrilla from the Turkish coasts within the frame of the present study

Soft-bottom decapod and stomatopod crustaceans of Northern Cyprus coast

The first study on decapod and stomatopod crustacean fauna of Cyprus was carried out by Heller (1863). According to research studies, until recently 156 species of decapods are recorded (47 Natantia, 12 Macrura Reptantia, 24 Anomura, 73 Brachyura) (Kocataş et al., 2001; Doğan et al., 2008; Christodoulou et al., 2009). Cyprus is the only island in Levantine Basin and is surrounded by waters of Levantine Basin, eastern Mediterranean, which are characterized by higher temperature and salinity, in comparison to the rest of Mediterranean (Kocataş et al., 2001). Recently, one study was done on the nearshore soft bottom macrofauna around Cyprus (Hadjichristophorou et al., 1997). They analysed macrobenthic fauna of soft-bottoms in Cyprus coasts, and reported 429 species with 73 Crustacea (71 Decapods and 2 Stomatopods)

Socioeconomic inequalities in psychological distress among urban adults

__Background:__ Various studies have reported socioeconomic inequalities in mental health among urban residents. This study aimed at investigating whether neighborhood social cohesion influences the associations between socio-economic factors and psychological distress. __Methods:__ Cross-sectional questionnaire study on a random sample of 18,173 residents aged 16 years and older from 211 neighborhoods in the four largest cities in the Netherlands. Psychological distress was the dependent variable (scale range 10-50). Neighborhood social cohesion was measured by five statements and aggregated to the neighborhood level using ecometrics methodology. Multilevel linear regression analyses were used to investigate cross-level interactions, adjusted for neighborhood deprivation, between individual characteristics and social cohesion with psychological distress. __Results:__ The mean level of psychological distress among urban residents was 17.2. Recipients of disability, social assistance or unemployment benefits reported higher psychological distress (β = 5.6, 95%CI 5.2 to 5.9) than those in paid employment. Persons with some or great financial difficulties reported higher psychological distress (β = 3.4, 95%CI 3.2 to 3.6) than those with little or no financial problems. Socio-demographic factors were also associated with psychological distress, albeit with much lower influence. Living in a neighborhood with high social cohesion instead of low social cohesion was associated with a lower psychological distress of 22% among recipients of disability, social assistance or unemployment benefits and of 13% among citizens with financial difficulties. __Conclusions:__ Residing in socially cohesive neighborhoods may reduce the influence of lack of paid employment and financial difficulties on psychological distress among urban adults. Urban policies aimed at improving neighborhood social cohesion may contribute to decreasing socio-economic inequalities in mental health

Investment Opportunities Forecasting: Extending the Grammar of a GP-based Tool

In this paper we present a new version of a GP financial forecasting tool, called EDDIE 8. The novelty of this version is that it allows the GP to search in the space of indicators, instead of using pre-specified ones. We compare EDDIE 8 with its predecessor, EDDIE 7, and find that new and improved solutions can be found. Analysis also shows that, on average, EDDIE 8's best tree performs better than the one of EDDIE 7. The above allows us to characterize EDDIE 8 as a valuable forecasting tool