Experimental data in support of continuous microwave effect on emulsion polymerization of styrene

AbstractThis article contains original experimental data, figures and methods to the study of Microwave-assisted emulsion polymerization of styrene under the frame of “Enhanced Microwave Synthesis” (EMS), has been examined to investigate the advantages of Microwave (MW) power use in emulsion polymerization (Ergan et al., Eur. Polym. J. 69, 2015, 374–384). For comparative purpose, MW and conventional heating (CH) method experiments were conducted under similar conditions. By externally cooling the reaction vessel with 1,4-dioxane, constant and continuous MW power was successfully applied at isothermal condition during the polymerization. Here we give the MW power calibration data of MW-experimental system, the complete set of the experimental polymerization data and the analysis data obtained from different polymer characterization test devices (GPC, DSC and Viscometer)

Konvansiyonel Tedavilere ve Splenektomiye Refrakter Primer Myelofibrozisli Olguda Ruxolitinib Deneyimi

A 67-year-old male patient who was diagnosed with primary myelofibrosis 4 years ago did not respond to conventional therapies. The splenomegaly progressively increased, which caused spleen infarctions and led to the decision to perform a splenectomy procedure. After splenectomy, the patient started treatment with ruxolitinib. In the first month of ruxolitinib treatment, the patient became transfusion-free and all constitutional symptoms disappeared. However, in the sixth month of ruxolitinib treatment, the disease transformed to acute myeloblastic leukemia, and the patient died 1 month later. This is the first case report that shows the effects of ruxolitinib in a splenectomized patient

Bedeutung des Risikofaktors „Lebensalter“ für die chirurgische Behandlung des kolorektalen Karzinoms: postoperative Komplikationen und Langzeitüberleben

Das Ziel dieser retrospektiven Studie war zu ermitteln, ob das Lebensalter ein Risikofaktor für die chirurgische Behandlung des Darmkrebses darstellt. Hierfür wurden 517 Patienten, die von Januar 2000 bis Dezember 2004 an einem kolorektalen Karzinom im Universitätsklinikum Rostock radikal operiert wurden, in 2 Altersgruppen eingeteilt, wobei als Grenze das 75. Lebensjahr gewählt wurde. Altersabhängige Analysen der perioperativen Daten ergaben keinen signifikanten Unterschied in der p.o. Morbidität sowie Mortalität, und die niedrigere tumorbezogene Überlebensrate in der älteren Gruppe konnte auf die inkonsequentere adjuvante bzw. palliative Nachbehandlung zurückgeführt werden

TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis

Objective: Nasal Polyp (NP) is a benign mass of the paranasal sinuses that protrudes into the nasal cavity. The exact underlying pathogenesis is not known. In this study we aimed to determine the genetic susceptibility of NP formation in relation to TNF-α-308 and IL-1β-511 promoter region gene polymorphisms.Methods: A total of 71 patients with NP with asthma (n=21) or without asthma (n=50) were taken as the study group, and 91 healthy volunteers were taken as the control group. Blood was gathered into EDTA-containing tubes, and patient DNA was extracted. The polymorphisms of the IL-β and TNF-α cytokine genes were analyzed using real time polymerase chain reaction.Results: The GG genotype in the TNF-α-308 region and the CC genotype in the IL-1β-511 region were found to be risk factors for NP formation (OR: 9.2, p=0.007 and OR: 33.3, p=0.001, respectively). Regarding allelic frequencies, the G allele at the TNF-α-308 promoter region was a risk factor for NP formation (OR: 6.06, p<0.001).Conclusion: TNF-α GG genotype in the -308 promoter region and the IL-1β CC genotype in the -511 region are genetic risk factors for NP formation

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

İstanbul Vakıflar Halı Müzesinin markalaşma süreci

ÖZETMüzecilik, Halı Müzesi ve marka konusunun incelendiği bu çalışmada müzecilik konusundaki gelişmeler, değişimler, yeni yaklaşımlar ve markalaşma deneyimleri, Halı Müzesi örneğinden hareketle irdelenmektedir. Tarih boyunca kültürel mirasa çok önemli katkılarda bulunan müzecilik anlayışı, 21. yüzyıl dünyasında önemli bir eğitim ve iletişim kurumu olarak karşımıza çıkmaktadır. Müzeler, günümüzün devasa modern yaşam merkezleri gibi kentlerin en önemli sosyal çekim alanlarından biri olmuş durumdadırlar. Literatürde uluslararası anlaşmazlıkları çözüme kavuşturabilmenin başlıca yöntemi savaş veya diplomasidir. Diplomasi devletler arasındaki ilişkileri bir orkestra şefi titizliğiyle idare etme sanatıdır. Çok hızlı gelişen kitle iletişim vasıtaları ve dünyadaki küreselleşme süreci, 1990 öncesi Soğuk Savaş dö¬neminden çok farklı bir uluslararası sistem ortaya çıkarmıştır. Artık sadece devletlerin ve hükümetlerin değil, bunların yanında milli ve uluslararası sahada hükümet harici organizasyonların, sivil toplum kuruluşlarının ve medyanın da etkili olduğu bir dünyada yaşanmaktadır. Kamu diplo-masisi çalışmaları içinde en etkili olan tekniklerden olan kültürel diplomasi daha kalıcı ve kesin sonuçlar elde edilmesi açısından önemlidir. Kültürel diplomasi, bir aktörün, kültürel kaynaklarını ve başarılarını ülke dı¬şına taşıyarak, uluslararası platformu yönetme girişimi olarak tanımlanabilir. Farklı toplumlarda kalıcı bir etki elde etmek büyük ölçüde kültürel diplomasinin aktif uygulamaları ile mümkündür. Bir ülkenin başka ülkeleri kültürel ögeleriyle etki altına alması anlamında kullanılan “yumuşak güç” sosyal bütünlük içerisinde kültürüyle diğer ülkeleri etkileyişini anlatan bir kavramdır. Günümüzde, uluslararası arenada kültürel miras, yumuşak güç kavramı içerisinde en etkin unsurlardan biri olarak değerlendirilmektedir.Bir tarafta kültüre ait kurumların en üst sırasında yer alan müzecilik anlayışı, diğer tarafta ise piyasa odaklı, sektörel bir terim olan markayı bir araya getirmek çok kolay olmasa da dünyada başarılı örnekleri görüldüğünden, ülkemizde Halı Müzesi çağdaş müzecilik anlamında gelişmeye açık bir konumdadır.ABSTRACTIn this study examining museology, the Carpet Museum and branding, the developments, changes, new approaches in and branding experiences of museums are examined through the example of the Carpet Museum. The concept of museology, which has made very important contributions to cultural heritage throughout the history, emerges as an important educational and communication institution in the 21st century. Museums, just like the gigantic and modern urban living centers of today, have become one of the most important social attractions of cities. The main method in the literature for solving international disagreements is war or diplomacy. Diplomacy is the art of manipulating relations between states with an orchestra chief's meticulousness. The rapidly developing mass media and the globalization process in the world have created an international system that is very different from the pre-1990s Cold War era. Today, a world, where not only the states and governments but also national and international non-governmental and civil society organizations and the media are influential, exists. Cultural diplomacy, one of the most effective techniques in public diplomacy work, is important in terms of obtaining more permanent and precise results. Cultural diplomacy can be defined as an actor’s attempt to lead the international platform by carrying its cultural resources and achievements out of the country. Achieving a lasting impact in different societies is to a great extent possible with the active application of cultural diplomacy. A concept that is defined as a country’s influencing other countries with its cultural elements, “soft power” is a concept that tells about a country’s socially cohesive cultural impact on others. Today, cultural heritage is regarded as one of the most effective elements within the scope of the concept of soft power in the international arena.While it is not easy to bring together the concept of museology on the one hand, which is located at the top of cultural institutions, and a sector-oriented term, branding on the other hand, since successful examples are witnessed around the world, the Carpet Museum in Turkey is in an open to development position in the sense of contemporary museology

İstanbul Vakıflar Halı Müzesi’ nin markalaşma süreci

Müzecilik, Halı Müzesi ve marka konusunun incelendiği bu çalışmada müzecilik konusundaki gelişmeler, değişimler, yeni yaklaşımlar ve markalaşma deneyimleri, Halı Müzesi örneğinden hareketle irdelenmektedir. Tarih boyunca kültürel mirasa çok önemli katkılarda bulunan müzecilik anlayışı, 21. yüzyıl dünyasında önemli bir eğitim ve iletişim kurumu olarak karşımıza çıkmaktadır. Müzeler, günümüzün devasa modern yaşam merkezleri gibi kentlerin en önemli sosyal çekim alanlarından biri olmuş durumdadırlar. Literatürde uluslararası anlaşmazlıkları çözüme kavuşturabilmenin başlıca yöntemi savaş veya diplomasidir. Diplomasi devletler arasındaki ilişkileri bir orkestra şefi titizliğiyle idare etme sanatıdır. Çok hızlı gelişen kitle iletişim vasıtaları ve dünyadaki küreselleşme süreci, 1990 öncesi Soğuk Savaş dö¬neminden çok farklı bir uluslararası sistem ortaya çıkarmıştır. Artık sadece devletlerin ve hükümetlerin değil, bunların yanında milli ve uluslararası sahada hükümet harici organizasyonların, sivil toplum kuruluşlarının ve medyanın da etkili olduğu bir dünyada yaşanmaktadır. Kamu diplo-masisi çalışmaları içinde en etkili olan tekniklerden olan kültürel diplomasi daha kalıcı ve kesin sonuçlar elde edilmesi açısından önemlidir. Kültürel diplomasi, bir aktörün, kültürel kaynaklarını ve başarılarını ülke dı¬şına taşıyarak, uluslararası platformu yönetme girişimi olarak tanımlanabilir. Farklı toplumlarda kalıcı bir etki elde etmek büyük ölçüde kültürel diplomasinin aktif uygulamaları ile mümkündür. Bir ülkenin başka ülkeleri kültürel ögeleriyle etki altına alması anlamında kullanılan “yumuşak güç” sosyal bütünlük içerisinde kültürüyle diğer ülkeleri etkileyişini anlatan bir kavramdır. Günümüzde, uluslararası arenada kültürel miras, yumuşak güç kavramı içerisinde en etkin unsurlardan biri olarak değerlendirilmektedir. Bir tarafta kültüre ait kurumların en üst sırasında yer alan müzecilik anlayışı, diğer tarafta ise piyasa odaklı, sektörel bir terim olan markayı bir araya getirmek çok kolay olmasa da dünyada başarılı örnekleri görüldüğünden, ülkemizde Halı Müzesi çağdaş müzecilik anlamında gelişmeye açık bir konumdadır. ABSTRACT In this study examining museology, the Carpet Museum and branding, the developments, changes, new approaches in and branding experiences of museums are examined through the example of the Carpet Museum. The concept of museology, which has made very important contributions to cultural heritage throughout the history, emerges as an important educational and communication institution in the 21st century. Museums, just like the gigantic and modern urban living centers of today, have become one of the most important social attractions of cities. The main method in the literature for solving international disagreements is war or diplomacy. Diplomacy is the art of manipulating relations between states with an orchestra chief's meticulousness. The rapidly developing mass media and the globalization process in the world have created an international system that is very different from the pre-1990s Cold War era. Today, a world, where not only the states and governments but also national and international non-governmental and civil society organizations and the media are influential, exists. Cultural diplomacy, one of the most effective techniques in public diplomacy work, is important in terms of obtaining more permanent and precise results. Cultural diplomacy can be defined as an actor’s attempt to lead the international platform by carrying its cultural resources and achievements out of the country. Achieving a lasting impact in different societies is to a great extent possible with the active application of cultural diplomacy. A concept that is defined as a country’s influencing other countries with its cultural elements, “soft power” is a concept that tells about a country’s socially cohesive cultural impact on others. Today, cultural heritage is regarded as one of the most effective elements within the scope of the concept of soft power in the international arena. While it is not easy to bring together the concept of museology on the one hand, which is located at the top of cultural institutions, and a sector-oriented term, branding on the other hand, since successful examples are witnessed around the world, the Carpet Museum in Turkey is in an open to development position in the sense of contemporary museology

Ruxolitinib Treatment in a Patient with Primary Myelofibrosis Resistant to Conventional Therapies and Splenectomy: A Case Report

A 67-year-old male patient who was diagnosed with primary myelofibrosis 4 years ago did not respond to conventional therapies. The splenomegaly progressively increased, which caused spleen infarctions and led to the decision to perform a splenectomy procedure. After splenectomy, the patient started treatment with ruxolitinib. In the first month of ruxolitinib treatment, the patient became transfusion-free and all constitutional symptoms disappeared. However, in the sixth month of ruxolitinib treatment, the disease transformed to acute myeloblastic leukemia, and the patient died 1 month later. This is the first case report that shows the effects of ruxolitinib in a splenectomized patient