New Antimicrobial Polymeric Microspheres Containing Azomethine

Herein, new polymeric microspheres containing azomethine (PS-OPA, PS-OPA-Pt, PS-OPA-Ni, PS-OPA-Mn and PS- OPA-Cu) were synthesized and investigated by elemental analysis, FT-IR, SEM-EDX, TGA-DTA, UV-Vis, GPC and magnetic susceptibility. Antibacterial and antifungal activities of the synthesized polymeric microspheres were evaluated against pathogenic bacteria (Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Staphylococcus aureus ATCC25923, Enterobacter aerogenes, Pseudomonas aeroginosa sp., Klebsiella pneumonia ATCC27853, Salmonella type H NCTC9018394, Proteus vulgaris RSKK96026, Escherichia coli ATCC1280) and yeast (Candida albicans Y-1200-NIH) by the well-diffusion method for potential biomedical applications. It was determined that polymeric microspheres exhibited higher inhibition effect against B. cereus, E. aerogenes, P. aeruginosa, P. vulgaris and showed higher antifungal activity than standard nystatin. [GRAPHICS

Ortografi sonrası tasarım ortamı olarak görselleme.

This thesis initially aims to reveal representational processes considered as “natural” to architecture. Based on the fact that architecture is reliant on its image, these processes are revisited in their technical terms in order to be able to “denaturalize” architectural design process. Particularly, the consideration of drawing and its technical qualities as inherent to architecture disguises the limitations they impose on the architectural work. Also, the institutionalization of drawing in the educational settings of architecture obscures the necessity to re-question these limitations. The thesis reasons these limitations through the linear rule of drawing and its reliance on bodily performance. Following John May’s proposition that “Everything is Already an Image,” image manipulation is explored as a “post-orthographic” design medium eliminating the fragmentation and mechanization of design process, which are the consequences of linearity and embodiment of drawing. The thesis also speculates on how imaging techniques render certain practices of contemporary architectural education redundant, incompatible, or even detrimental.Thesis (M.Arch.) -- Graduate School of Natural and Applied Sciences. Architecture

Yüksek duyarlıklı C-reaktif protein düzeyleri ve safen ven greft hastalığı arasındaki ilişkinin değerlendirilmesi

Amaç: Bu çalışmada safen ven greft hastalığı (SVGH) ile yüksek duyarlıklı C-reaktif protein (hs-CRP) seviyeleri arasındaki ilişki değerlendirildi. Çalışma planı: Çalışmaya koroner arter baypas greft ameliyatı öyküsü olan, önceden belirlenen objektif kriterlere göre koroner anjiyografi yapılan toplam 78 hasta (54 erkek, 24 kadın; ort. yaş 60.4±9.4 yıl; dağılım 37-78 yıl) dahil edildi. Ateroskleroza neden olan risk faktörleri sorgulandı ve tüm hastaların biyokimyasal testleri çalışıldı. Safen ven greftlerden herhangi birinde %50 ve daha fazla darlık olması SVGH olarak tanımlandı. Hastalar SVGH olan (grup 1) ve SVGH olmayanlar (grup 2) olmak üzere iki gruba ayrıldı. Bulgular: Her iki grubun demografik özellikleri ve laboratuvar değerleri karşılaştırıldığında, grup 1’de vücut kütle indeksi (VKİ), total kolesterol/yüksek yoğunluklu lipoprotein (HDL) kolesterol, ürik asit (ÜA) ve hs-CRP düzeyleri anlamlı oranda yüksek olup, HDL kolesterol düzeyi anlamlı oranda düşüktü. Yapılan çok değişkenli lojistik regresyon analizinde VKİ, ÜA ve hs-CRP düzeylerinin SVGH’yi öngörmede bağımsız belirteçler olduğu tespit edildi (hs-CRP OR: 1.522, p<0.01, ÜA OR: 1.48, p=0.01, VKİ OR: 1.31, p=0.04). Yapılan ROC analizinde hs-CRP düzeyi 0.8 mg/dL ‘‘kesim değeri’’ olarak alındığında %80 duyarlılık ve %85 özgüllük oranı ile SVGH’yi belirlediği bulundu. Sonuç: Çalışmamızda SVGH’yi öngördüren en güçlü belirtecin hs-CRP olduğu saptandı. Yüksek duyarlıklı C-reaktif protein, SVGH varlığını öngörme ve izleminde noninvaziv, güvenilir ve yararlı bir belirteçtir.Background: In this study, we aimed to evaluate the relationship between the levels of high-sensitivity C-reactive protein (hs-CRP) and saphenous venous graft disease (SVGD). Methods: A total of 78 patients (54 males, 24 females; mean age 60.4&plusmn;9.4 years; range 37 to 78 years) with previous history of coronary artery bypass graft (CABG) surgery who underwent coronary angiography based on predetermined objective clinical criteria were included. Risk factors leading to atherosclerosis were questioned and biochemical tests were studied in all patients. A 50% or more stenosis in at least one of the saphenous vein grafts was defined as SVGD. The patients were divided in two groups according to the presence of SVGD (group 1), and the absence of SVGD (group 2). Results: When we compared the demographic characteristics and laboratory findings of both groups, body mass index (BMI), total cholesterol/high-density lipoprotein (HDL) cholesterol ratio, uric acid (UA) and hs-CRP levels were significantly higher, while HDL cholesterol level was significantly lower in group 1. Multivariate logistic regression analysis showed that BMI, UA and hs-CRP levels were independent predictors of SVGD (hs-CRP OR: 1.522, p&lt;0.01, UA OR: 1.48, p=0.01, BMI OR: 1.31, p=0.04). The ROC analysis demonstrated that a 0.8 mg/dL hs-CRP cut-off value indicated SVGH with a 80% sensitivity and 85% specificity rate. Conclusion: In our study, hs-CRP was found to be the most powerful predictor of SVGD. High-sensitivity-C-reactive protein is a noninvasive, reliable and useful parameter in the prediction and monitoring of SVGD

Identification and quantification of phenolic and volatile constituents in five different Anatolian thyme species using LC–MS/MS and GC-MS, with biological activities

Being widely used in the food industry, thyme is one of the most valuable plants in many aspects, and Turkey is one of the hotspots for thyme industry. Five thyme species,Thymus convolutus(endemic),Thymus fallax,Thymus haussknechtiiVelen (endemic),Thymus kotschyanusvar.kotschyanus, andThymus sipyleusfrom Turkey were subjected in this study. Their essential oils and the extracts of aerial and root parts were obtained. GC-MS analyses showed that camphor was the major compound inT. convolutus(12.7%), and inT. sipyleus(13.1%) essential oils. The major volatile compound ofT. fallaxwas bicyclogermacrene (21.5%), whereas theT. kotschyanusvar.kotschyanusessential oil showed a predominance of carvacrol (48.5%), and thymol (22.5%). Carvacrol was also the major compound ofT. haussknechtiiwith 28.2%. LC-MS/MS analyses showed that nicotiflorin (293.28–4201.15μg/mL), caffeic (516.41–851.28μg/mL), quinic (344.37–4410.94μg/mL), rosmarinic (1800.18–9631.71μg/mL), and fumaric acid (350.88–682.10μg/mL) were detected as the main compounds in the extracts. All extracts exerted strong antioxidant activity, and the highest radical scavenging activity was demonstrated byT. haussknechtiiroot extract.T. convolutusandT. haussknechtiiaerial parts extracts showed significant antimicrobial activity againstC. tropicalisat MIC of 19.53μg/mL.The extracts were found to be non-toxic against COLO205 and KM12 human colon, and UO-31, and A498 human renal cell lines. Their enzyme inhibitory activities were also evaluated against cholinesterase, tyrosinase and urease enzymes andT. fallaxaerial part extract was the most effective with 34.48±0.60% in antibutyrylcholinesterase activity.These species with strong antioxidant and antifungal properties and no toxicity could be beneficial to be used as preservatives in the food processing industry