Pseudobullous Anetodermic Pilomatricoma

Pilomatricoma (PM) is an asymptomatic, slowly growing, benign skin tumour originating from primitive cells of the hair matrix and hair shaft and appears mostly on the head, neck, and the upper extremities. Typical lesion is usually characterized by a solitary, firm, deep-seated dermal or subcutaneous nodule, covered by normal or erythematous skin, and usually varying in size from 0.5 to 3 cm. Bullous appearance can occur on the lesions of bullous PM and anetodermic PM which are located in the rare atypical forms of PM. Here, we present an 11-year-old girl with an anetodermic PM on her right arm that showed thick-walled flaccid bullous formation over it

High dose zoledronic acid increases ischemia-reperfusion damage of the liver

OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been reported to exhibit a protective effect against cancers and prevent bone fractures. It also induces apoptosis by increasing proinflammatory cytokines and oxidative stress. Oxidative stress increases significantly during ischemia-reperfusion (IR) injury. The liver is highly sensitive to IR injury. In this study, we aim to investigate whether high-dose ZA treatment affects the liver during IR. MATERIALS AND METHODS: We used twenty-one Sprague-Dawley male rats in our study. and they were subdivided randomly into three groups, each containing seven rats. A single dose of 100 pg/kg ZA was administered via the intraperitoneal route in the ZA group. Forty-eight hours after the ZA administration, infrarenal abdominal aortic cross ligation was performed on the ZA and IR groups. After 2 hours of ischemia, 2 hours of reperfusion was applied. RESULTS: The malondialdehyde (MDA) level of the control group was significantly lower than the IR (p = 0.006) and ZA (p<0.001) groups. However, the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) values of the control group were significantly higher than the values of the IR group (p<0.05. p<0.001, and p<0.05) and ZA group (p = 0.002, p<0.001, and p<0.001). Caspase-3 activity was significantly higher in the IR group as compared to the control group (p<0.001). The caspase-3 activity in the ZA group, on the other hand, was higher than both the control (p<0.001) and IR groups (p<0.001). CONCLUSIONS: High-dose ZA may exacerbate liver injury during IR by increasing reactive oxygen species production and apoptosis

Tick bite cases among hazelnut farm workers in Giresun

Ticks are arthropod vectors of many diseases. The prevalence of Lyme disease transmitted by Ixodes is not known in Turkey. The disease is caused by Borrelia species and can also be seen in domestic animals. The aim of this study is to identify the ticks, which are collected from the agricultural workers who admitted to hospitals during the hazelnut harvest season between August and September 2015, at species and genus level and investigate whether these ticks vector of Borrelia spp. Method: In this study, 152 ticks collected from 134 patients were investigated. Of all samples including larvae and nymphs, 95.24% were collected in September. All patients who admitted with complaints of tick bites were agricultural workers collecting nuts in the gardens at sea level. The ticks were identified at species and genus level with stereomicroskop, hemolymph fluid examined directly by dark-field microscope and cultured in the Borellia BarbourStoenner-Kelly (BSK-H) medium. Results: Of all the ticks, 126 (82.9%) were adults, 13 (8.55%) were nymphs and 13 (8.55%) were larvae. Stereoscopic examination of the ticks revealed that 125 (82.2%) of the adults were Ixodes ricinus and 1 (0.65%) was Rhipicephalus sanguineus. All of the 13 nymphs (8.55%) and 13 larvae (8.55%) were identified as Ixodes spp.. All forms of development cycle were detected in the samples and the forms were inconsistent with the expected development cycle. Borrelia spp., the agent of Lyme disease, was investigated in the 146 ticks defined as I. ricinus and Ixodes spp. Borrelia spp were detected by dark field microscope in 3 (2.05%) of the 146 Ixodes and Borrelia spp. were identified in 5 (3.4%) of the cultures. Conclusions: These results demonstrate that Lyme disease can be seen in our region and the most probable vector is Ixodes ricinus

Growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) gene polymorphisms in Turkish native cattle breeds

The aim of this study was to determine the genetic diversity of 4 native Turkish cattle breeds, based on the growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) genes. In order to study the polymorphisms in these genes, the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method was performed. A 329-bp fragment and a 223-bp fragment of GH, a 156-bp fragment of PRL, and a 411-bp fragment of DGAT1, thus 4 loci of 3 genes, were amplified via PCR. These fragments were then restricted with the enzymes MspI, Alu1, RsaI, and CfrI, respectively. In this study, 2 types of alleles, (+) and (-) for the GH-MspI, L and V for the GH-Alu1, A and B for the PRL, and K and A for the DGAT1 loci, were observed. The results of the present study will contribute to the polymorphism data on the world's cattle breeds. Furthermore, the above-mentioned allele frequencies of Turkish native breeds are evaluated in relation to their genetic relatedness, and to infer their milk production properties on the basis of the available literature. In turn, these results can be utilized for future breeding programs of dairy cattle in Turkey

Recent Advances in Health Biotechnology During Pandemic

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in 2019, cut the epoch that will make profound fluctuates in the history of the world in social, economic, and scientific fields. Urgent needs in public health have brought with them innovative approaches, including diagnosis, prevention, and treatment. To exceed the coronavirus disease 2019 (COVID-19) pandemic, various scientific authorities in the world have procreated advances in real time polymerase chain reaction (RT-PCR) based diagnostic tests, rapid diagnostic kits, the development of vaccines for immunization, and the purposing pharmaceuticals for treatment. Diagnosis, treatment, and immunization approaches put for- ward by scientific communities are cross-fed from the accrued knowledge of multidisciplinary sciences in health biotechnology. So much so that the pandemic, urgently prioritized in the world, is not only viral infections but also has been the pulsion in the development of novel approaches in many fields such as diagnosis, treatment, translational medicine, virology, mi- crobiology, immunology, functional nano- and bio-materials, bioinformatics, molecular biol- ogy, genetics, tissue engineering, biomedical devices, and artificial intelligence technologies. In this review, the effects of the COVID-19 pandemic on the development of various scientific areas of health biotechnology are discussed

Acıyı Dizelere Dökmek: Servet-İ Fünun Dönemi Şiirlerinde Acı Çeken Beden

In this study, we examined which sources of pain were taken up by poets in Servet-i Fünun Period poetry, how these changes led to changes in the body and how poets reflected this in their poems. in this period, instead of examining every poet who wrote poetry, we identified a few poets who were popular according to their degree of influence. We tried to draw the general profile of the period with the data we obtained from them. We identified the sources of pain, divided them into groups, ordered them from less to the most preferred, and included two representative examples instead of addressing all the poems in the same group one by one. But we have taken all of them into consideration when making our evaluations. As a general conclusion, in this period, the pain of individual origin mostly destroys the body. in this period, the source of pain is mostly disease. Even love, which is the second most common source of pain, is often described as an illness. Diseases in the poetry to enter this degree is influenced by the change from Western poetry. This change in particular affects the way the patient looks at the body. Because the sick body, which is normally approached with pity or disgust, is described as having a distinct beauty due to its proximity to death in this period. This pale skin and weakness adds a separate, spiritual beauty to the body.Bu çalışmada Servet-i Fünun dönemi şiirlerinde acının hangi kaynaklarının şairler tarafından ele alındığını, bunların bedende nasıl değişikliklere yol açtığını ve şairlerin bunu şiirlerine nasıl yansıttığını inceledik. Bu dönemde şiir kaleme almış her şairi incelemek yerine döneme etki derecesine göre popüler olan birkaç şairi belirledik. Onlardan elde ettiğimiz verilerle genellemeye gitmeye çalıştık. Acının kaynaklarını tespit ettik, gruplara ayırdık, en çok işlenenden aza doğru sıraladık ve aynı grupta yer alan tüm şiirleri tek tek ele almak yerine temsilî bir iki örneğe yer verdik. Fakat değerlendirmelerimizi yaparken hepsini göz önünde bulundurduk. Genel bir sonuç olarak söylemek gerekirse bu dönemde çoğunlukla bireysel kökenli acılar bedeni tahrip eder. Bu dönemde acının kaynağı çoğunlukla hastalıktır. Hatta acının en çok işlenen ikinci kaynağı olan aşk bile çoğunlukla bir hastalık gibi anlatılır. Hastalıkların şiirlere bu derecede yoğun girmesinde Batı şiirinden gelen değişimin etkisi görülür. Bu değişim özellikle hasta bedene bakışı etkiler. Çünkü normalde acıma ya da iğrenme duygusuyla yaklaşılan hasta beden, bu dönemde ölüme yakınlığı dolayısıyla ayrı bir güzelliğe sahip olarak tasvir edilir. Bu solgunluk ve güçsüzlük bedene ayrı, ruhani bir güzellik katar

Ofset baskı mürekkeplerine yapılan fiziksel testlerin uygulamalı incelenmesi

ÖZETOFSET BASKI MÜREKKEPLERİNE YAPILAN FİZİKSEL TESTLERİN UYGULAMALI İNCELENMESİ Ofset baskı mürekkeplerinin üretimi sırasında yapılan fiziksel testler mürekkebin baskı sırasındaki performansı ile doğrudan ilgilidir. Mürekkep standardındaki bir sapma baskı sırasında baskı altı malzemesiyle uyumsuzluklara, su mürekkep dengesizliğine kısacası büyük problemlere sebep olabilmekte, baskı operatörleri de bu problemlerin çözümünde çaresiz kalabilmektedir. Bu projede ofset baskı mürekkeplerine fiziksel testlerin nasıl yapılacağı ayrıntılarıyla anlatılmış, uygulamalı olarak yapılmış ve testlerin yapımı sırasında hata yapılaması için alınabilecek tedbirler belirtilmiştir.Çalışmada fiziksel testlerin yapımı sırasında izlenilecek yol maddelerle anlatılmıştır. Cold-set, heat-set, sheet-fed mürekkep çeşitlerinin öncelikli olarak yaş numunelerine vizkozite ölçümü ve sıçratma testi, tack ölçümü yapılmıştır. Bu mürekkepler ile prüfbau test baskı cihazında baskıları alınmış, bu baskılara densite, parlaklık, ışık haslığı ölçümü, sürtünme testi yapılarak pigmet yapılarına ve yağ yapılarına göre farklı olan mürekkepler karşılaştırılmıştır. Baskıları yapılan ve pigment yapılarına göre karşılaştırılan mürekkepler verimlilik, parlaklık açısından karşılaştırılmış ve mürekkebin yapısal farklılıkların ne gibi sonuçlar getirdiği ortaya çıkarılmıştır.ABSTRACTTHE APPLIED INVESTIGATION OF THE PHYSICAL TESTS OF THE OFFSET PRINTING INKDuring the production of offset printing inks, performed physical tests are directly related with the performance of inks during the printing process. A deviation from the standard printing ink can cause major problems like ink-substrate incompatibilities, ink-water imbalances, etc. In the solution of this problems printing operators may be helpless.In this Project, How to do physical tests of offset printing inks have been described in detail, and tests have been applied and measures can be taken to not make mistakes during tests have been indicated.In this study, itineraries during the performing tests have been described. Primarily, viscosity measurement, tack measurement and splash test were made with the samples of cold-set, heat-set and sheet-fed offset printing inks. Test prints of theese ink samples were printed on the printing test equipment. Density, gloss/brightness, light fastness, lab measurements and friction test were made to the test prints, and so different inks according the their pigment and oil structures were compared. And also theese test prints and ink samples were compared in terms of efficiency and brightness. Eventually, structural differencies of offset printing inks are what make as a result has been uncovered

Ofset baskı mürekkeplerine yapılan fiziksel testlerin uygulamalı incelenmesi

OFSET BASKI MÜREKKEPLERİNE YAPILAN FİZİKSEL TESTLERİN UYGULAMALI İNCELENMESİ Ofset baskı mürekkeplerinin üretimi sırasında yapılan fiziksel testler mürekkebin baskı sırasındaki performansı ile doğrudan ilgilidir. Mürekkep standardındaki bir sapma baskı sırasında baskı altı malzemesiyle uyumsuzluklara, su mürekkep dengesizliğine kısacası büyük problemlere sebep olabilmekte, baskı operatörleri de bu problemlerin çözümünde çaresiz kalabilmektedir. Bu projede ofset baskı mürekkeplerine fiziksel testlerin nasıl yapılacağı ayrıntılarıyla anlatılmış, uygulamalı olarak yapılmış ve testlerin yapımı sırasında hata yapılaması için alınabilecek tedbirler belirtilmiştir. Çalışmada fiziksel testlerin yapımı sırasında izlenilecek yol maddelerle anlatılmıştır. Cold-set, heat-set, sheet-fed mürekkep çeşitlerinin öncelikli olarak yaş numunelerine vizkozite ölçümü ve sıçratma testi, tack ölçümü yapılmıştır. Bu mürekkepler ile prüfbau test baskı cihazında baskıları alınmış, bu baskılara densite, parlaklık, ışık haslığı ölçümü, sürtünme testi yapılarak pigmet yapılarına ve yağ yapılarına göre farklı olan mürekkepler karşılaştırılmıştır. Baskıları yapılan ve pigment yapılarına göre karşılaştırılan mürekkepler verimlilik, parlaklık açısından karşılaştırılmış ve mürekkebin yapısal farklılıkların ne gibi sonuçlar getirdiği ortaya çıkarılmıştır. ABSTRACT THE APPLIED INVESTIGATION OF THE PHYSICAL TESTS OF THE OFFSET PRINTING INK During the production of offset printing inks, performed physical tests are directly related with the performance of inks during the printing process. A deviation from the standard printing ink can cause major problems like ink-substrate incompatibilities, ink-water imbalances, etc. In the solution of this problems printing operators may be helpless. In this Project, How to do physical tests of offset printing inks have been described in detail, and tests have been applied and measures can be taken to not make mistakes during tests have been indicated. In this study, itineraries during the performing tests have been described. Primarily, viscosity measurement, tack measurement and splash test were made with the samples of cold-set, heat-set and sheet-fed offset printing inks. Test prints of theese ink samples were printed on the printing test equipment. Density, gloss/brightness, light fastness, lab measurements and friction test were made to the test prints, and so different inks according the their pigment and oil structures were compared. And also theese test prints and ink samples were compared in terms of efficiency and brightness. Eventually, structural differencies of offset printing inks are what make as a result has been uncovered