Investigation of Thyroid Metabolism Diseases in Kütahya Region

Aim: The study was performed on the sera sent for other diagnostic purposes like thyroid function tests (thyroid-stimulating hormone, total triiodothyronine and total thyroxin) to the Laboratory of Kütahya Hıfzısıhha Institute. Material and Method: Patients visiting 13 health care centers province and districts of Kütahya province were included in this study. The study popula-tion consisted of 320 patients. Serum levels of cholesterol, trigliserid, HDL-cholesterol, LDL-cholesterol and lipid were measured. Results: The results of our study showed 250 individuals (78.12%) to be within normal ranges, 42 (13.12%) as hypothyroid, and 28 (8.75%) were hyperthyroid. Hypothyroid pa-tients had significantly higher levels of cholesterol, LDL-cholesterol, lipid and thyroid-stimulating hormone levels (p<0.05). While hyperthyroid patients had significantly lower levels of cholesterol, LDL-cholesterol and lipid levels when compared with patients with normal thyroid hormone levels (p<0.05); Thyroxin levels were significantly higher (p<0.05). Discussion: The results of this study showed that the population under study was at risk of goiter diseases

First records of anomalously white harbour porpoises (Phocoena phocoena) in the Turkish seas with a global review

Dede, Ayhan/0000-0002-7712-615X; YESILCICEK, TUNCAY/0000-0002-3236-8227; Tonay, Arda M./0000-0003-2718-9328; Kose, Ozay/0000-0002-3565-160XWOS: 000320413100012Three anomalously white harbour porpoises (Phocoena phocoena) were reported in Turkish Seas. One of them was bycaught on 19 June 2011 in bottom gill nets off the eastern coast of the Turkish Black Sea. the second one was observed four times in May and early June 2012 in the Istanbul Strait. the last one was stranded alive on 7 July 2012 in the Istanbul Strait. Records (published and unpublished) of anomalously white harbour porpoises in the world were reviewed. in total, 34 records were found from the world seas: the Black Sea, North Sea, Baltic Sea, North Atlantic Ocean and North Eastern Pacific Ocean. According to these records, three patterns of pigmentation were suggested.Recep Tayym Erdogan UniversityRecep Tayyip Erdogan University [BAP 2010.103 03 2]; Istanbul UniversityIstanbul University [BAP 184761, BAP 27942]The authors thank S. Berrow, O K. Didockson, K. Flannery, PG H Evans, A. Gob, Z. Gunelidze, I Hasselmeier, L Hutchings, W Keener, C.C. Kinze, L Morison, S. Pezeril, D. Quigley, K Robinson, D. Schulte, R Sears, A. U for observation data and old photos, A. Beird for photos, A.E. Kutukcu for video in Istanbul Strait, E. Danyer and I Aytemiz for necropsy report, H Bayar for necropsy assistance, 13 Topaloglu for photos of case 3 and logistic, S. Akmermer, K Akmermer and U. Akmermer for help in Size, L Eadie, T de Haas, N. Tonay and Kirecburnu's fishermen in Istanbul, Coast Guard for cooperation in IU/TUDAV Cetacean Stranding Network; V. Onar and P.S C. Turetken for help in fixation case 3, P Korkmazel, K. Guzey/ANIMA for colour grading and video time warping, B. Ozturk, P Gol'din and D Fertl for their valuable advises; A A Ozturk, R. Bilgin, C. Torso for their contributions during editing Case I study was supported by Recep Tayym Erdogan University, Scientific Research Project (BAP 2010.103 03 2). Case 2 study was supported by Istanbul University, Scientific Research Pealed (BAP 184761 Case 3 preserving and exhibit was provided by Istanbul University, Scientific Research Project (BAP 27942

Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study

Purpose: High fructose corn syrup (HFCS) is used commonly in the food industry and has been associated with various diseases including obesity, diabetes and fatty liver. Ghrelin, an orexigenic hormone with widespread receptors in many tissues, exerts various central and peripheral effects. Food intake may reduce its synthesis. Kisspeptin plays a major role in reproductive hormones and its receptors are expressed in tissues with high metabolic activity, such as the liver. This study aims to investigate the effects of HFCS consumption on liver tissue and its relationship with Kisspeptin and Ghrelin levels. Materials and Methods: Fourteen adult male Wistar albino rats, aged eight to ten weeks, were used in this study and divided into two groups; Control and HFCS (n=7). Tumor Necrosis Factor-alpha (TNF-α), Ghrelin, and Kisspeptin levels in the liver tissues of the rats were measured using an immunohistochemical method and subsequently analyzed through histoscoring. Results: Our data revealed a significant increase in Kisspeptin, Caspase 3, and TNF-α levels and a decrease in Ghrelin levels in the HFCS group compared to the Control group. Conclusion: In conclusion, our study demonstrates, for the first time, changes in liver Kisspeptin levels induced by a high fructose diet. Furthermore, the consumption of HFCS in food led to inflammatory activation, tissue damage, and reduced Ghrelin levels

Logistics process improvement of Kapikule border crossing

Önsel Ekici, Şule (Dogus Author) -- Çekyay, Bora (Dogus Author) -- Özaydın, Özay (Dogus Author) -- Toktaş Palut, Peral (Dogus Author) -- Conference full title: The 15th International Logistics and Supply Chain Congress (LMSCM), October 19, 2017 through October 20, 2017 in Istanbul, TurkeyIn this study, logistics process improvement of Kapikule Border Crossing, one of the largest customs gates, has been evaluated. It is obvious that, any decrease in trade time is expected to realize positive impact on the logistics competitiveness of a specific country. In order to reduce time across all dimensions of the border process, the improvement of physical infrastructure and the proliferation of procedures are the most important issues that should be focused on. The aim of the study is to improve the Kapikule border crossing by reducing the process time. For this purpose, first, in-depth interviews were conducted with the Kapikule customs gate authorities in order to reveal explicitly the process flows. Subsequently, the current situation at the gate was simulated using the Arena simulation software. Finally, several improvement scenarios were tested to identify the ones that will have the highest impact on reducing the queues and the delays at the border

Morphology, Myxocarpy, Mineral Content And İn Vitro Antimicrobial And Antiproliferative Activities Of Mericarps Of The Vulnerable Turkish Endemic Salvia Pilifera

Salvia L., the largest genus of the family Lamiaceae, is composed of many well-known plants of medicinal value. This study provides the first data on micromorphology, myxocarpy, mineral content and in vitro antimicrobial and antiproliferative activities of mericarps of Salvia pilifera, considered to be a vulnerable endemic species from Turkey. The macro-and micromorphological mericarp traits were documented and illustrated via stereo microscopy and scanning electron microscopy. Mineral content of mericarps was analyzed using ICP-MS. Ethanol extract of mericarps was tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Acinetobacter baumannii, Aeromonas hydrophila, Candida albicans, Candida tropicalis, and Candida glabrata using broth microdilution method. Antimycobacterial activity was performed against Mycobacterium tuberculosis H37Rv using resazurin microtiter plate method. Ampicillin, Ethambutol, Isoniazid, and Fluconazole were chosen as reference drugs. Antiproliferative effect of the extract was tested against A549 human lung cancer cell lines using MTT test. The size of the mericarps was 4.38±0.17 mm in length and 3.28±0.13 mm in width. The general shape was elliptic to widely elliptic. The abscission scar was nearly rounded. The ornamentation pattern of the surface was colliculate with polygonal exocarp cells. Myxocarpy was observed on the surface of the mericarps when they become hydrated. Transparent mucilaginous cells showed a moderate reaction with extensions more than 0.1 mm long. Potassium and calcium were determined as major minerals (80.662±0.234 and 41.892±0.399 µg/g, respectively). The extract showed greater antibacterial activity against A. baumannii compared to Ampicillin (62.5 and 125 µg/mL MIC values, respectively). Cell viability level of the extract (100 ?g/mL) was found to be statistically lower than control group against A549 human lung cancer cell lines (P<0.05). © 2019 Marmara University Press.Afyon Kocatepe ÜniversitesiWe offer grateful thanks to Lecturer Serhat T?k?z at The Technology Application and Research Centre (TUAM), Afyon Kocatepe University (Afyonkarahisar, Turkey) for taking excellent SEM micrographs; Dr. Erkan Halay at Scientific Analysis and Technological Research and Application Center (UBATAM), Usak University (Usak, Turkey) for ICP analysis

Does glioblastoma cyst fluid promote sciatic nerve regeneration?

Glioblastoma cyst fluid contains growth factors and extracellular matrix proteins which are known as neurotrophic and neurite-promoting agents. Therefore, we hypothesized that glioblastoma cyst fluid can promote the regeneration of injured peripheral nerves. To validate this hypothesis, we transected rat sciatic nerve, performed epineural anastomosis, and wrapped the injured sciatic nerve with glioblastoma cyst fluid- or saline-soaked gelatin sponges. Neurological function and histomorphological examinations showed that compared with the rats receiving local saline treatment, those receiving local glioblastoma cyst fluid treatment had better sciatic nerve function, fewer scars, greater axon area, counts and diameter as well as fiber diameter. These findings suggest that glioblastoma cyst fluid can promote the regeneration of injured sciatic nerve and has the potential for future clinical application in patients with peripheral nerve injury