Ru(III), Cr(III), Fe(III) complexes of Schiff base ligands bearing phenoxy Groups: Application as catalysts in the synthesis of vitamin K3

Two polydentade Schiff base ligands and their Ru(III), Cr(III) and Fe(III) complexes were synthesized and characterized by elemental analysis (C, H, N), UV/Vis, FT IR, 1H and 13C NMR, LC–MS/MS, molar conductivity and magnetic susceptibility techniques. The absorption bands in the electronic spectra and magnetic moment measurements verified an octahedral environment around the metal ions in the complexes. The thermal stabilities were investigated using TGA. The synthesized complexes were used in the catalytic oxidation of 2-methyl naphthalene (2MN) to 2-methyl-1,4-naphthoquinone; vitamin K3, menadione, 2MNQ; using hydrogen peroxide, acetic acid and sulfuric acid. L1-Fe(III) complex showed very efficient catalytic activity with 58.54% selectivity in the conversions of 79.11%. Keywords: Schiff base, Ru(III), Cr(III) and Fe(III) complexes, Catalyst, Vitamin K, Menadion

A Case with Mega Cisterna Magna Renal and Ear Anomalies: Is This a New Syndrome?

Background. Extrarenal pathologies may be associated with renal position and fusion anomalies. According to the literature, our patient is the first horseshoe kidney case that had mega cisterna magna, arachnodactyly, and mild mental retardation. Case Report. A 9-year-old boy admitted because of the myoclonic jerks. He had a dysmorphic face, low-set and cup-shaped ears, arachnodactyly, and mild mental retardation. The patient’s laboratory findings were normal except for a mild leucocytosis and hypochromic microcytic anemia. His cerebrospinal fluid was cytologically and biochemically normal. Cranial MRI revealed 1.5 cm diametered mega cisterna magna in the retrocerebellar region. Although there were no significant epileptical discharges in the electroencephalography, there were slow wave discharges arising from the anterior regions of both hemispheres. Because he had stomachache, abdominal ultrasonography was performed, and horseshoe kidney was determined. Abdominal CT did not reveal any abnormalities except the horseshoe kidney. There were not any cardiac pathologies in echocardiography. He had normal 46XY karyotype and there were no repeated chromosomal derangements, but we could not evaluate for molecular and submicroscopic somatic changes. He was treated with valproic acid and myoclonic jerks did not repeat. Conclusion. We suggest that the presence of these novel findings may represent a newly recognized, separate syndrome

Childhood brucellosis in southeastern region of Turkey : a retrospective analysis

Amaç: Bu çalışmada dört yıllık süreçte brusellozis tanısıyla yatırılarak takip ve teda- vi edilen hastaların demografik ve klinik özelliklerinin değerlendirilmesi amaçlandı. Yöntemler: Retrospektif olarak yapılan bu çalışmaya 2003-2007 yılları arasında Dicle Üniversitesi Çocuk İnfeksiyon Hastalıkları Servisine brusellozis tanısı ile yatırılan 34 olgu alındı. Hastaların demografik özellikleri, klinik yakınmaları, fizik muayene ve laboratuvar bulguları değerlendirildi. Standart tüp aglütinasyon testi, Rose Bengal testi ve klinik bulgular tanı kriteri olarak kullanıldı. Bulgular: Hastaların 12 (%35)’si kız, 22 (%65)’si erkekti. Hastaların ortalama yaşı 9,2±3,4 yıl idi. 21 (%61,7) hasta kırsal alandan başvurmuştu. İki hasta dışında tüm hastalar, çiğ süt ve süt ürünleri tüketmişti. Hastaların yakınma ve bulguların arasın- da ateş (30, %88,2) ve kas-iskelet sistem yakınmaları (26, %76,4) ön plandaydı. Laboratuvar incelemelerinde hematolojik tutulum belirgindi. Tedavide sekiz yaşın- dan küçük çocuklara trimetoprim-sulfametoksazol+rifampisin, sekiz yaşından büyük- lere doksisiklin+rifampisin 6 hafta boyunca uygulandı. Dört hastada relaps görüldü. Sonuç: Brusellozisin başvuru nedenleri arasında kas iskelet sistem yakınmaları ve ateş ilk sıradadır. Hematolojik sistem bulguları olan hastada brusellozis ayırıcı tanı- lar arasında olmalıdır. Tedavinin başarılı olması ve relaps oluşmaması için kombine tedaviler yeterli süre verilmelidir.Objective: To evaluate the clinical and laboratory findings, treatment modalities and outcomes of children with brucellosis in a four-year period Methods: This retrospective study included 34 children who were admitted to Dicle University Pediatric Infectious Diseases Service with brucellosis between 2003-2007. Demographic features, clinical symptoms, physical examination and laboratory fin- dings of patients were evaluated. The standard tube agglutination test, Rose Bengal test and clinical findings were used as diagnostic criteria for brucellosis. Results: In the study, twelve patients (35%) were female and 22 (65%) were male. The mean age was 9.2±3.4 years. Twenty-one patients (61.7%) were from rural areas of Turkey. All of the children except two patients have reported to consume unprocessed milk and dairy products. The most frequent complaints and clinical findings were fever (88.2%) and musculo-skeletal system symptoms (76.4%). Hematological invol- vement was significantly apparent in laboratory results. Trimethoprim- sulfamethoxazole+rifampicin were administered to children smaller than 8 years and doxycycline+rifampicin to children older than 8 years during 6 weeks for treatment. Four patients were relapsed. Conclusion: Musculoskeletal system complaints and fever are the most common symptoms in brucellosis. Brucellosis should be considered in the differential diagnosis of patients with hematological signs. Combined treatments should be administered within a sufficient period to provide successful treatment and prevent relapse

Splenectomy in patients with thalassemia major: Evaluation of 35 cases

Amaç: Beta talasemi, b globin sentezinin azalması veya hiç üretilememesi sonucunda oluşan, otozomal resesif geçişli ve yeryüzünde yaygın görülen kalıtsal anemi tipidir. Splenektomi, birçok hematolojik hastalıkta tedavi amaçlı uygulanabilmektedir. Bu çalış- mada, kliniğimizden takipli talasemi major hastalarından splenektomi yapılan hastaların kayıtlı bilgilerinin tartışılması amaçlandı. Yöntemler: Takipli 782 talasemi major hastasının kayıtları geriye dönük olarak tarandı. Bu hastalardan splenektomi yapılmış ve kayıtlı bilgilerine ulaşılabilen 35 hasta çalışmaya dâhil edildi. Hastaların kayıtlı bilgileri, tanı alma yaşları, cinsiyet durumları, operasyon yaşları, operasyon endikasyonları, şelasyon tedavisi, transfüzyon sıklıkları ve ameliyat sonrası klinik yanıt durumları açısından detaylı incelendi. İstatistiksel incelemede SPSS 13.0 İstatistik programı kullanıldı. Bulgular: Hastaların 22si (%63) erkek, 13ü (%37) kız idi. Ortalama tanı alma yaşı 82 ay, splenektomi yaşı 8,5 yıl idi. En önemli splenektomi endikasyonu artmış transfüzyon gereksinimiydi (%57,14). Ameliyat öncesi transfüzyon gereksinimi, 23530 mL/kg/yıl iken; ameliyat sonrası gözlemlerde 11515 mL/kg/yıla kadar gerilemişti. Splenektomi öncesi ortalama serum ferritin düzeyi 1745761 ng/mL, splenektomi sonrası 1985570 ng/mL idi. İzlemlerde hiçbir hastada sepsis veya pıhtılaşma bozukluğu gibi herhangi bir komplikasyon gelişmedi. Sonuç: Talasemi hastalarında splenektomi yakınmaların azaltılması ve transfüyon sıklığının azaltılmasında faydalıdır. Demir şelasyon tedavisinin yetersiz uygulanması ile splenektomiye gidiş zamanı arasında bir korelasyon olabilir.Objective: Beta-thalassemia is common, worldwide, autosomal recessive and inherited type of anemia which results from absent or reduced synthesis of b globin. Splenectomy may be performed for the treatment of many hematologic diseases. The aim of this study is to discuss recorded data of thalassemia major patients who underwent splenectomy. Methods: The records of 782 patients with thalassemia major were reviewed retrospectively. Of these patients, 35 splenectomized patients with available data were included in the study. Recorded data of patients were evaluated as for age at diagnosis, gender, age at splenectomy, surgical indications, chelation therapy, annual transfusion requirements, and postoperative clinical response. Statistical analyses were performed with statistical package of SPSS version 13.0. Results: Twenty-two (63%) male and 13 (37%) female patients were included in the study. Mean age at diagnosis was 8±2 months and splenectomy was 8.5 years. The main indication for splenectomy was increased transfusion requirement (57.14%). The annual transfusion requirement reduced from preoperative 235±30 mL/kg to 115±15 mL/kg postoperatively. Mean serum ferritin levels were 1745±761 ng/mL, and 1985±570 ng/mL before, and after splenectomy. None of the patients developed any complications such as sepsis or coagulation disorder. Conclusion: These results suggest that splenectomy is beneficial to improve the quality of the lives of patients and significantly reducing blood consumption. Inadequate iron chelation therapy may be associated with progression to splenectomy

Splenectomy in patients with thalassemia major: Evaluation of 35 cases

Amaç: Beta talasemi, b globin sentezinin azalması veya hiç üretilememesi sonucunda oluşan, otozomal resesif geçişli ve yeryüzünde yaygın görülen kalıtsal anemi tipidir. Splenektomi, birçok hematolojik hastalıkta tedavi amaçlı uygulanabilmektedir. Bu çalış- mada, kliniğimizden takipli talasemi major hastalarından splenektomi yapılan hastaların kayıtlı bilgilerinin tartışılması amaçlandı. Yöntemler: Takipli 782 talasemi major hastasının kayıtları geriye dönük olarak tarandı. Bu hastalardan splenektomi yapılmış ve kayıtlı bilgilerine ulaşılabilen 35 hasta çalışmaya dâhil edildi. Hastaların kayıtlı bilgileri, tanı alma yaşları, cinsiyet durumları, operasyon yaşları, operasyon endikasyonları, şelasyon tedavisi, transfüzyon sıklıkları ve ameliyat sonrası klinik yanıt durumları açısından detaylı incelendi. İstatistiksel incelemede SPSS 13.0 İstatistik programı kullanıldı. Bulgular: Hastaların 22si (%63) erkek, 13ü (%37) kız idi. Ortalama tanı alma yaşı 82 ay, splenektomi yaşı 8,5 yıl idi. En önemli splenektomi endikasyonu artmış transfüzyon gereksinimiydi (%57,14). Ameliyat öncesi transfüzyon gereksinimi, 23530 mL/kg/yıl iken; ameliyat sonrası gözlemlerde 11515 mL/kg/yıla kadar gerilemişti. Splenektomi öncesi ortalama serum ferritin düzeyi 1745761 ng/mL, splenektomi sonrası 1985570 ng/mL idi. İzlemlerde hiçbir hastada sepsis veya pıhtılaşma bozukluğu gibi herhangi bir komplikasyon gelişmedi. Sonuç: Talasemi hastalarında splenektomi yakınmaların azaltılması ve transfüyon sıklığının azaltılmasında faydalıdır. Demir şelasyon tedavisinin yetersiz uygulanması ile splenektomiye gidiş zamanı arasında bir korelasyon olabilir.Objective: Beta-thalassemia is common, worldwide, autosomal recessive and inherited type of anemia which results from absent or reduced synthesis of b globin. Splenectomy may be performed for the treatment of many hematologic diseases. The aim of this study is to discuss recorded data of thalassemia major patients who underwent splenectomy. Methods: The records of 782 patients with thalassemia major were reviewed retrospectively. Of these patients, 35 splenectomized patients with available data were included in the study. Recorded data of patients were evaluated as for age at diagnosis, gender, age at splenectomy, surgical indications, chelation therapy, annual transfusion requirements, and postoperative clinical response. Statistical analyses were performed with statistical package of SPSS version 13.0. Results: Twenty-two (63%) male and 13 (37%) female patients were included in the study. Mean age at diagnosis was 8±2 months and splenectomy was 8.5 years. The main indication for splenectomy was increased transfusion requirement (57.14%). The annual transfusion requirement reduced from preoperative 235±30 mL/kg to 115±15 mL/kg postoperatively. Mean serum ferritin levels were 1745±761 ng/mL, and 1985±570 ng/mL before, and after splenectomy. None of the patients developed any complications such as sepsis or coagulation disorder. Conclusion: These results suggest that splenectomy is beneficial to improve the quality of the lives of patients and significantly reducing blood consumption. Inadequate iron chelation therapy may be associated with progression to splenectomy

Vibrational spectroscopic and thermo dynamical property studies, Fukui functions, HOMO-LUMO, NLO, NBO and crystal structure analysis of a new Schiff base bearing phenoxy-imine group

This study covers the synthesis, structural characterization by experimental FT-IR, H-1 NMR and C-13 NMR, UV-Vis and single crystal XRD and comparison with theoretical calculations of a Schiff base compound bearing phenoxy group, C34H28N2O4 by using the DFT method 6-311G(d,p) basis set. The molecular geometry, the dipole moments, electrostatic potential, vibrational frequencies, HOMO-LUMO energy were calculated. NBO, NLO, thermodynamic properties and Fukui function were studied. In this work, theoretical values show good agreement with experimental values. (C) 2017 Elsevier B.V. All rights reserved