Evaluation of serum prolactin le-vels in children with febrile and afebrile convulsions

Bu çalışmada, konvülziyon geçiren çocuklarda serum prolaktin düzeyine bakarak epileptik durumları nonepileptik durumlardan ayırt etmede bu ölçütü kullanıp kullanamayacağımızı değerlendirmek istedik. Gereç ve yöntem: Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Çocuk Sağlığı ve Hastalıkları Kliniği’ne febril ve afebril konvülziyon geçirerek getirilen 2 yıllık süreçteki toplam 51 olgu analiz edildi. Febril konvülziyon geçiren 8 erkek, 9 kız yaşları 32,8+- 22,9 ay olan toplam 17 çocuk grup 1’i oluşturdu. Grup 2 de ise ortalama yaş 76,4+- 48,4 ay olan 20 erkek, 14 kız toplam 34 çocuktan oluştu. Grup 3 ise 24 erkek, 26 kız poliklini ğimize konvülziyon dışı yakınmayla başvuran toplam 50 çocuktan oluşan kontrol grubuydu. Olgularda konvülziyon sonrası 1. saatte, 2. saatte ve 24. saatte venöz kan alınarak serum prolaktin düzeyi bakıldı. Bulgular: Serum prolaktin birinci saat değerleri afebril grupta (grup 2), febril gruba (grup 1) göre anlamlı yüksek bulundu. Serum prolaktininin postkonvulzif 24. saat değeri açısından 3 grup karşılaştırıldığında istatistiksel açıdan anlamlı farklılık tespit edilmedi. Sonuç: Çalışmamız afebril konvülziyonda birinci saatte bakılan prolaktin düzeyinin anlamlı yüksekliği bize epileptik nöbetlerin nonepileptik durumlardan ayrımında, EEG monitorizasyonu zor ula- şılabilir bir yöntem olduğu için, bu yöntemi kullanabileceğimizi göstermektedir.In this study, we wanted to evaluate if we can use the serum prolactin levels as a marker in differential diagnosis epileptic syndromes and non epileptic ones. Materials and methods We analyzed totally 51 children during two years who were admitted to our clinic by having experienced febrile or afebrile convulsions. Group 1 included 8 male and 9 female totally 17 children whose mean ages were 32.8+/- 22.9 months and had febrile convulsions. Group 2 had 20 males and 14 females 76.4 +/- 48.4 months aged totally 34 children who had experienced afebrile convulsions. Group 3 included 24 males 26 females who had no neurologic symptoms or convulsions but taken to our clinic by other symptomatologies. Blood samples of cases were evaluated in the first hour, in the second and 24.hour of post convulsive follow-up. Results: We found that serum prolactin levels were significantly higher in the afebril convulsive group (group 2) than in the febrile convulsive group (group1). Serum prolactin levels of post convulsive 24.hour determination revealed no statistically difference between the three groups. Conclusion: In this study, we concluded that, we can use serum prolactin levels in the first hour of post convulsive follow-up for differential diagnosis of epileptic syndromes and non epileptic ones, since EEG monitorization is a hardly performed evaluation

The evaluation of vitamin K status in children with febrile seizure

Background: Febrile seizure is the most common neurological disorder in childhood. The exact pathophysiology of febrile seizures is unknown. Recent studies showed the role of vitamin K in nonhematological and inflammatory disorders. This study aimed to investigate the serum vitamin K levels in children with febrile seizures. Aims: To evaluate vitamin K levels in children with febrile seizures. Study Design: Prospective case-control study. Methods: This multicenter study examined representative populations in 8 different cities in Turkey between April 1, 2018 and April 1, 2019. Blood samples were taken from all children at presentation. Vitamin K1, vitamin K2, tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels were determined by enzyme-linked immunosorbent assay. Results: A total of 155 children were included in the study—84 children with febrile seizures and 71 children in febrile control group. Serum vitamin K1 and vitamin K2 levels were also higher in children with febrile seizures than in the controls. The results of statistical analysis showed that vitamin K1 and vitamin K2 levels were correlated with tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels. The median vitamin K1 and vitamin K2 levels of children experiencing their first febrile seizure were higher than those in children with recurrent febrile seizures. Type of febrile seizure has no effect on serum vitamin K1 and vitamin K2 levels. Conclusion: In children with febrile seizures, vitamin K levels are higher than those in the control group. These new findings may contribute to elucidating the etiopathogenesis of febrile seizures

Retrospective evaluation of the autoacoustic emission test and auditory brainstem response in risky newborns

Introduction: The early development of the sense of hearing in the baby affects both language and language development considerably, as well as emotional, social and mental development. Hearing loss, which higher in newborns with risk factors, is 1-2% incidence in 1000 live births. Evoked Otoacoustic Emissions (EOAE) and Auditory Brainstem Response (ABR) methods are used in neonatal hearing screenings. We aimed to evaluate the EOAE and ABR results of the newborns in this study and the comparison of the two tests. Methods: Between January 2011 and July 2011, 104 newborns with a high-risk factor in our hospital were evaluated retrospectively. Results: The risk factors for the congenital anomaly, be in intensive care and neonatal hyperbilirubinemia, were found to be statistically significantly higher in the Hearing Loss group (+) than in the Hearing Loss group (-). In logistic regression analysis, it was determined that neonatal hyperbilirubinemia was a significant risk factor for hearing loss. Discussion and Conclusion: Our findings contributed to the national data and our findings suggest that neonatal hyperbilirubinemia increases the risk of hearing loss

Evaluation of the Seroprevalence of Hepatit A and Vaccination Status in Children Aged Two and Sixteen Years

Objective: In this study; the aim was to evaluate the seroprevalence of hepatitis A virus (HAV) in 2-16 year age group, and the rate of hepatitis A vaccination.\ud Materials and Methods: This study was conducted on 400 children aged between 2 and 16 years with no chronic diseases who attended the pediatrics outpatient clinic in Health Sciences University, Haydarpaşa Numune Training and Research Hospital. After obtaining informed consent from the parents, blood samples were taken for investigating serological markers for hepatitis A in the microbiology laboratory using the ELISA method. The parents were asked whether or not their children had been vaccinated against hepatitis A. \ud Results: In this study 44.3% of the participants included were girls and 55.8% were boys. The mean age of the children was 10.8±4.18 years. 27.3% of patients were anti-HAV IgG-positive, and 11% had been vaccinated against hepatitis A. When we compared preschool and school age patients, anti-HAV IgG positivity was detected in all children who were vaccinated in the preschool group; while 5.9% of unvaccinated children were anti-HAV IgG-positive and 94.1% were negative. It was found that school age children were unvaccinated, and anti-HAV IgG was positive in 19.6% of the children and negative in 80.4% of the children.\ud Conclusion: In our study, although the prevalence of hepatitis A was found to be low compared to the eastern and southeastern cities of our country, it is still higher than in the developed countries. In order to prevent hepatitis A infection, it is necessary to improve the socio-economic conditions of the country, to create better sanitary conditions and hygienic practices, and raise awareness of the infection

Immunomodulator effect of topical zinc oxide application in tuberculin skin test

WOS: 000433094100008PubMed ID: 29607430OBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. METHODS: We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later. RESULTS: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels. CONCLUSION: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis

The effects of antiepileptic therapies on se-rum lipid levels in childhood

Amaç: Biz bu çalışmayı, epileptik çocukların uzun süreli izleminde uygulanan antiepileptik tedavinin, lipid profiline etkisini araştırmak için yaptık. Materyal Metod: Bu çalışma, yaşları 2.5 ile 14 yaş arası değişen 56 çocuğu kapsamaktadır. Bunların ,ortalama yaş aralığı 8.71±3.3 yaştır. Çocukların 24’ü kız, 32’si erkektir. Çalışmaya alınan 19 çocuk generalize epilepsi, 37’si parsiyel epilepsi geçirmişti. Karbamazepin kullanan 16 çocuk grup I’i, okskarbazepin kullanan 21 çocuk grup II’yi, sodyum valproat kullanan 19 çocuk grup III’ü oluşturdu. Tedavinin başlangıcında, 3., 6. ve 12. aylarında, venöz kan alınarak serum kolesterol, VLDL, LDL, HDL, trigliserit seviyeleri bakıldı. Bulgular: Gruplar arasında başlangıç, 3., 6. ve 12. serum total kolesterol, VLDL, LDL, HDLve trigliserit seviyeleri açısından anlamlı farklılık bulunmadı. Sonuç: Oniki ay boyunca uygulanan antiepileptik tedavi, gruplar arasında lipid seviyeleri ( kolesterol, HDL, LDL, VLDL, trigliserit )üzerine anlamlı değişiklik göstermedi. Bir yıllık,izlemde serum lipid seviyelerinin etkilenmediği sonucuna vardık.Objective: We performed this study, in order to investigate the effects of antiepileptic therapies on serum lipid levels during long term follow- up of epileptic children. Material and Method: This study included 56 children, whose ages were 8.71±3.3 years. Twentyfour of children were female and 32 of whom were male. When 19 children had generalize epilpsies, 37 had parsiyel ones. Carbamazepin has been experienced on 16 ( grup I ), Okskarbazepin on 21 ( grup II ) and sodium valproat has been experienced on 19 children .At beginning and during, the third, sixth and twelfth months of antiepileptic therapies, serum lipid levels were evaluated. Results: There was no statiscially difference for serum total colesterol levels among the groups during the 3., 6., 12. months controls. Serum trigliserit LDL, HDL, VLDLcholesterol levels revealed no significant difference as well, among the groups during monthly (3., 6., 12. month) controls. Conclusion : The groups who were followed by different antiepileptic therapies revealed no significant difference for serum lipid levels during 12 months.We concluded that, antiepileptic therapies did not affect serum lipid levels during one year follow-up