Primitive neuroectodermal tumor coexistent with anaplastic ganglioglioma

Abstract Primitive neuroectodermal tumors are among the most common tumors of childhood and th

Evaluation of serum prolactin le-vels in children with febrile and afebrile convulsions

Bu çalışmada, konvülziyon geçiren çocuklarda serum prolaktin düzeyine bakarak epileptik durumları nonepileptik durumlardan ayırt etmede bu ölçütü kullanıp kullanamayacağımızı değerlendirmek istedik. Gereç ve yöntem: Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Çocuk Sağlığı ve Hastalıkları Kliniği’ne febril ve afebril konvülziyon geçirerek getirilen 2 yıllık süreçteki toplam 51 olgu analiz edildi. Febril konvülziyon geçiren 8 erkek, 9 kız yaşları 32,8+- 22,9 ay olan toplam 17 çocuk grup 1’i oluşturdu. Grup 2 de ise ortalama yaş 76,4+- 48,4 ay olan 20 erkek, 14 kız toplam 34 çocuktan oluştu. Grup 3 ise 24 erkek, 26 kız poliklini ğimize konvülziyon dışı yakınmayla başvuran toplam 50 çocuktan oluşan kontrol grubuydu. Olgularda konvülziyon sonrası 1. saatte, 2. saatte ve 24. saatte venöz kan alınarak serum prolaktin düzeyi bakıldı. Bulgular: Serum prolaktin birinci saat değerleri afebril grupta (grup 2), febril gruba (grup 1) göre anlamlı yüksek bulundu. Serum prolaktininin postkonvulzif 24. saat değeri açısından 3 grup karşılaştırıldığında istatistiksel açıdan anlamlı farklılık tespit edilmedi. Sonuç: Çalışmamız afebril konvülziyonda birinci saatte bakılan prolaktin düzeyinin anlamlı yüksekliği bize epileptik nöbetlerin nonepileptik durumlardan ayrımında, EEG monitorizasyonu zor ula- şılabilir bir yöntem olduğu için, bu yöntemi kullanabileceğimizi göstermektedir.In this study, we wanted to evaluate if we can use the serum prolactin levels as a marker in differential diagnosis epileptic syndromes and non epileptic ones. Materials and methods We analyzed totally 51 children during two years who were admitted to our clinic by having experienced febrile or afebrile convulsions. Group 1 included 8 male and 9 female totally 17 children whose mean ages were 32.8+/- 22.9 months and had febrile convulsions. Group 2 had 20 males and 14 females 76.4 +/- 48.4 months aged totally 34 children who had experienced afebrile convulsions. Group 3 included 24 males 26 females who had no neurologic symptoms or convulsions but taken to our clinic by other symptomatologies. Blood samples of cases were evaluated in the first hour, in the second and 24.hour of post convulsive follow-up. Results: We found that serum prolactin levels were significantly higher in the afebril convulsive group (group 2) than in the febrile convulsive group (group1). Serum prolactin levels of post convulsive 24.hour determination revealed no statistically difference between the three groups. Conclusion: In this study, we concluded that, we can use serum prolactin levels in the first hour of post convulsive follow-up for differential diagnosis of epileptic syndromes and non epileptic ones, since EEG monitorization is a hardly performed evaluation

Epidemiology of Pediatric Brain Tumors Epidemiology of Pediatric Brain Tumors

Abstract Malignant brain tumors are one of the most important causes of death i

150-60 Management of Pediatric Severe Head Trauma

Abstrac

Decompression, spinal distraction and fusion in nerve root compression due to Paget's disease

Ağrı ve kas zaafına yol açan kök basısı bulunan Paget hastalıklı bir olgu sunularak manyetik rezonans görüntüleri ve tedavi yöntemleri üzerinde durulmuştur. Paget hastalığındaki kontrolsüz ve fazla kemikleşme, manyetik rezonans görüntülemede kortikal bölgede kalınlaşma olarak görülür. Omur cismi yayvanlaşmıştır. İlik dokusu azalmış ve bağ dokusuyla bölünmüştür. Muhtemelen artmış dolaşım ve venöz göllenmeye bağlı olarak kontrast madde tutar. Paget hastalıklı omur nöral dokuya bası yaparsa cerrahi serbestleştirme yapılabilir. Hastamızda hem tanıyı doğrulamak hem de kökü serbestleştirmek için hemilaminektomi ve foraminotomi yapıldı. Ayrıca pedikül vidası yardımıyla omurga gerilerek köklerin daha da rahatlaması sağlandı ve füzyon uygulandı. Omurganın gerilmesinin kanalı genişlettiği bilinmektedir. İç sabitleyiciyle germe ve arka elemanlara füzyon işlemi hastalıklı ön ve orta kolonlara binecek yükü azaltarak çökme ve yayvanlaşmanın önüne geçecektir. Paget hastalığında artmış osteoblastik aktiviteyle hiperostoz ile blok omurgaya eğilim vardır ve bu sayede füzyon oluşması da kolaydır. Bu girişimlerden yararlanan hastanın tedavisi kalsitonin ile sürdürüldü ve takip edildiği sürede yakınması olmadı.A case of Paget's disease causing radicular pain and reduced muscle power is presented. MR imaging and therapeutic features are discussed. Excessive and uncontrolled bone reformation is imaged as decreased signal intensity in enlarged cortical areas on MR. The vertebra is flattened. The marrow is reduced and divided by connective tissue and is enhanced probably because of increased circulation and venous pooling. Surgical decompression is considered if Paget's disease of the vertebral column causes neural compression. We performed hemilaminectomy and foraminotomy to decompress the nerve root and for histological confirmation. Further root decompression is obtained by vertebral distraction by pedicle screw system, and osseous fusion is added. It is known that distraction improves the stenotic canal and foramen; besides internal fixation and fusion of the posterior elements reduce the pressure on the affected anterior and medial columns. Diffuse idiopathic skeletal hyperostosis has been reported in Pagetic patients and this may facilitate vertebral fusion. The patient benefited from the surgical procedure and remained asymptomatic during the follow-up under calcitonin treatment

Evaluation of the Seroprevalence of Hepatit A and Vaccination Status in Children Aged Two and Sixteen Years

Objective: In this study; the aim was to evaluate the seroprevalence of hepatitis A virus (HAV) in 2-16 year age group, and the rate of hepatitis A vaccination.\ud Materials and Methods: This study was conducted on 400 children aged between 2 and 16 years with no chronic diseases who attended the pediatrics outpatient clinic in Health Sciences University, Haydarpaşa Numune Training and Research Hospital. After obtaining informed consent from the parents, blood samples were taken for investigating serological markers for hepatitis A in the microbiology laboratory using the ELISA method. The parents were asked whether or not their children had been vaccinated against hepatitis A. \ud Results: In this study 44.3% of the participants included were girls and 55.8% were boys. The mean age of the children was 10.8±4.18 years. 27.3% of patients were anti-HAV IgG-positive, and 11% had been vaccinated against hepatitis A. When we compared preschool and school age patients, anti-HAV IgG positivity was detected in all children who were vaccinated in the preschool group; while 5.9% of unvaccinated children were anti-HAV IgG-positive and 94.1% were negative. It was found that school age children were unvaccinated, and anti-HAV IgG was positive in 19.6% of the children and negative in 80.4% of the children.\ud Conclusion: In our study, although the prevalence of hepatitis A was found to be low compared to the eastern and southeastern cities of our country, it is still higher than in the developed countries. In order to prevent hepatitis A infection, it is necessary to improve the socio-economic conditions of the country, to create better sanitary conditions and hygienic practices, and raise awareness of the infection

Immunomodulator effect of topical zinc oxide application in tuberculin skin test

WOS: 000433094100008PubMed ID: 29607430OBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. METHODS: We performed this study in 100 children aged 6-14 years, and plasma zinc levels were analyzed after 10-12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later. RESULTS: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels. CONCLUSION: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis