La correspondència de Cèsar Cui dirigida a Felip Pedrell (1893-1912)

La correspondència de Cèsar Cui (1832-1918) dirigida a Felip Pedrell (1841-1922) és un conjunt de 52 documents epistolars (43 cartes i 9 targetes postals) conservats a la Biblioteca de Catalunya amb la signatura M 964; escrites en francès, la seva cronologia abasta des del 8 de març de 1893 fins al 12 de febrer de 1912. En dues de les cartes Cèsar Cui va ometre la data d'escriptura, però el seu contingut les situa dintre d'aquest interval cronològic. L'estudi d'aquesta correspondència mostra aspectes diversos de la relació d'amistat dels compositors esmenats: la seva mútua admiració i els seus intercanvis d'idees, opinions, composicions, escrits i articles; suposa també un important retracte de la realitat social de la vida musical de finals del segle XIX, mitjançant els seus comentaris sobre aspectes personals, familiars i quotidians, sobre les dificultats per la representació de les seves obres, així com sobre altres personatges i institucions musicals de l'època.La correspondencia de César Cui (1835-1918) dirigida a Felip Pedrell (1841-1922) es un conjunto de 52 documentos epistolares (43 cartas y 9 tarjetas postales) conservados en la Biblioteca de Catalunya con la signatura M 964; escritas en francés, su cronología abarca desde el 8 de marzo de 1893 al 12 de febrero de 1912. En dos de las cartas César Cui omitió la fecha de escritura, pero su contenido las sitúa dentro de este intervalo cronológico. El estudio de esta correspondencia muestra diversos aspectos de la relación de amistad entre ambos compositores: su mutua admiración y los intercambios de ideas, opiniones, composiciones, escritos y artículos; supone también un importante retrato de la realidad social de la vida musical de finales del siglo XIX, a través de sus comentarios sobre aspectos personales, familiares y cotidianos, sobre las dificultades que ambos tenían para la representación de sus obras, así como sobre otros personajes e instituciones musicales de la época.La correspondance de César Cui (1835-1918) adressée à Felip Pedrell (1841-1922) est un ensemble de 52 documents épistolaires (43 lettres et 9 cartes postales) conservés à la Biblioteca de Catalunya sous le signet M 964; écrites en français, leur chronologie s'étend du 8 mars 1893 au 12 février 1912. César Cui a omis la date d'écriture dans deux lettres, mais leur contenu les situe à l'intérieur de cet intervalle chronologique. L'étude de cette correspondance montre divers aspects de la relation d'amitié entre les deux compositeurs : leur admiration mutuelle et les échanges d'idées, d'opinions, de compositions, d'écrits et d'articles ; elle suppose aussi un portrait important de la réalité sociale de la vie musicale à la fin du XIXe siècle, à travers leurs commentaires sur des aspects personnels, familiaux et quotidiens, sur les difficultés qu'ils rencontraient tous les deux pour la représentation de leurs oeuvres, ainsi que sur d'autres personnages et institutions musicales de l'époque.The correspondence of César Cui (1835-1918) addressed to Felip Pedrell (1841-1922) is a set of 52 epistolary documents (43 letters and 9 postcards) conserved in the Biblioteca de Catalunya with the signature M 964; written in French, their chronology covers the period from March 8, 1893 to February 12, 1912. César Cui omits the date when he wrote two of the letters, but their content situates them in this chronological period. A study of this correspondence reveals several aspects of the friendship between these two composers: their mutual admiration and exchanges of ideas, opinions, compositions, writings and articles; it is also an important portrait of the social reality of musical life in the late 19th century, through their comments about personal, family and everyday affairs, about the difficulties that they both faced to perform their works, and about other musical figures and institutions of the era.Die Korrespondenz, die César Cui (1835-1918) an Felip Pedrell (1841-1922) gerichtet hat, besteht aus insgesamt 52 Dokumenten (43 Briefe und 9 Postkarten), die in der Biblioteca de Catalunya unter der Signatur M 964 aufbewahrt werden. Die auf Französisch geschriebenen Schriftstücke umfassen die Zeit zwischen dem 8. März 1893 und dem 12. Februar 1912. Zwei Briefe sind nicht datiert, aber aus ihrem Inhalt geht hervor, dass sie innerhalb dieses Zeitraums geschrieben wurden. Das Studium dieser Korrespondenz legt verschiedene Aspekte der freundschaftlichen Beziehung zwischen beiden Komponisten an den Tag: ihre gegenseitige Bewunderung sowie der Austausch von Gedanken, Meinungen, Kompositionen, Texten und Artikeln. Ihre Kommentare über persönliche, familiäre und alltägliche Aspekte, über die Schwierigkeiten, die beide zur Aufführung ihrer Werke zu überwinden hatten, sowie über andere Musiker und Institutionen der Musik ihrer Epoche, sind gleichzeitig ein wichtiges Porträt der sozialen Wirklichkeit der Welt der Musik um die Jahrhundertwende

La música para piano de Felip Pedrell

La mayor parte de la producción pianística de Pedrell se concentra en los años 1862-1872, durante su juventud en Tortosa. Constituye un corpus importante de piezas que abarcan los géneros pianísticos propios de la época: nocturnos, valses, baladas, impromptus, estudios, fantasías, sonatas, apuntes sinfónicos, temas característicos. El estudio de este repertorio revela su importancia cuantitativa y cualitativa dentro de la producción compositiva de Pedrell; en ellas encontramos elementos desarrollados más tarde en obras de mayores dimensiones, junto a la clara influencia de la música y de la estética románticas del momento. El lenguaje, claramente pianístico, evidencia un conocimiento práctico del instrumento; la estructura compositiva,especialmente en las obras de dimensiones medias, revela un gusto por el desarrollo motívico, las modulaciones audaces y el cromatismo, si bien en un contexto tonal. En algunas ocasiones sobrepasa las características propias de la música de salón. Los diez últimos años de intensa creación pianística cesan súbitamente, abriendo el paso, desde 1873, hacia el Lied y la música escénica, como asimismo, a la búsqueda de un mayor desarrollo tímbrico.The main part of Pedrell’s pianistic production is centred on the years 1862-1871, during his youth in Tortosa. It makes up a considerable corpus of pieces that cover the pianistic genres of the time; nocturnes, waltzes, ballads, improvisations, studies, fantasies, sonnets, symphonic notes, characteristic topics. The study of this repertoire reveals its quantitative and qualitative importance in Pedrell’s production of compositions; in them we find features that were later developed in larger works, together with the clear influence of the romance music and aesthetic of the time. The language, clearly pianistic, shows a practical knowledge of the instrument; the composition structure, especially in the medium sized pieces, reveals a taste for motivic development, audacious modulations and chromatism, although in a tonal context. On some occasions the characteristics of ballroom music are exceeded. The last ten years of intense pianistic creation came to a sudden stop, making way for, from 1873, the Lied and stage music, and also for the search for better timbral development

The correspondence of César Cui addressed to Felip Pedrell (1893-1912)

La correspondència de Cèsar Cui (1832-1918) dirigida a Felip Pedrell (1841-1922) és un conjunt de 52 documents epistolars (43 cartes i 9 targetes postals) conservats a la Biblioteca de Catalunya amb la signatura M 964; escrites en francès, la seva cronologia abasta des del 8 de març de 1893 fins al 12 de febrer de 1912. En dues de les cartes Cèsar Cui va ometre la data d’escriptura, però el seu contingut les situa dintre d’aquest interval cronològic. L’estudi d’aquesta correspondència mostra aspectes diversos de la relació d’amistat dels compositors esmenats: la seva mútua admiració i els seus intercanvis d’idees, opinions, composicions, escrits i articles; suposa també un important retracte de la realitat social de la vida musical de finals del segle xix, mitjançant els seus comentaris sobre aspectes personals, familiars i quotidians, sobre les dificultats per la representació de les seves obres, així com sobre altres personatges i institucions musicals de l’època.La correspondencia de César Cui (1835-1918) dirigida a Felip Pedrell (1841-1922) es un conjunto de 52 documentos epistolares (43 cartas y 9 tarjetas postales) conservados en la Biblioteca de Catalunya con la signatura M 964; escritas en francés, su cronología abarca desde el 8 de marzo de 1893 al 12 de febrero de 1912. En dos de las cartas César Cui omitió la fecha de escritura, pero su contenido las sitúa dentro de este intervalo cronológico. El estudio de esta correspondencia muestra diversos aspectos de la relación de amistad entre ambos compositores: su mutua admiración y los intercambios de ideas, opiniones, composiciones, escritos y artículos; supone también un importante retrato de la realidad social de la vida musical de finales del siglo xix, a través de sus comentarios sobre aspectos personales, familiares y cotidianos, sobre las dificultades que ambos tenían para la representación de sus obras, así como sobre otros personajes e instituciones musicales de la época.The correspondence of César Cui (1835-1918) addressed to Felip Pedrell (1841-1922) is a set of 52 epistolary documents (43 letters and 9 postcards) conserved in the Biblioteca de Catalunya with the signature M 964; written in French, their chronology covers the period from March 8, 1893 to February 12, 1912. César Cui omits the date when he wrote two of the letters, but their content situates them in this chronological period. A study of this correspondence reveals several aspects of the friendship between these two composers: their mutual admiration and exchanges of ideas, opinions, compositions, writings and articles; it is also an important portrait of the social reality of musical life in the late 19th century, through their comments about personal, family and everyday affairs, about the difficulties that they both faced to perform their works, and about other musical figures and institutions of the era

Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.

The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens

Escuela para madres y padres sobre bilingüismo y aprendizaje del inglés

Memoria del proyecto de Aprendizaje y Servicio titulado Escuela para madres y padres sobre bilingüismo y aprendizaje del inglés, dirigido por el Dr. D. Daniel Martín González y financiado por la Oficina de Aprendizaje y Servicio de la UCM en la Convocatoria de Proyectos de Aprendizaje y Servicio 2021-22

Predictors of Loss of Functional Independence in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group

COPPADIS Study Group.[Background and objective] The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson’s disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD).[Patients and Methods] PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%.[Results] In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88.58 ± 10.19 to 84.26 ± 13.38; p < 0.0001; Cohen’s effect size = −0.519) was observed but not in controls (N = 124; from 98.87 ± 6.52 to 99.52 ± 2.15; p = 0.238). When only patients considered functional independent at baseline were included, 55 out of 463 (11.9%) converted to functional dependent at V2. To be a female (OR = 2.908; p = 0.009), have longer disease duration (OR = 1.152; p = 0.002), have a non-tremoric motor phenotype at baseline (OR = 3.574; p = 0.004), have a higher score at baseline in FOGQ (OR = 1.244; p < 0.0001) and BDI-II (OR = 1.080; p = 0.008), have a lower score at baseline in PD-CRS (OR = 0.963; p = 0.008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1.168; p = 0.0.29), FOGQ (OR = 1.348; p < 0.0001) and VAFS-Mental (OR = 1.177; p = 0.013) (adjusted R-squared 0.52; Hosmer and Lemeshow test = 0.94) were all found to be independent predictors of FD at V2.[Conclusions] In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.Fundación Curemos el Parkinson (www.curemoselparkinson.org).Peer reviewe

Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.

The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens

Predictors of clinically significant quality of life impairment in Parkinson’s disease

COPPADIS Study Group.Quality of life (QOL) plays an important role in independent living in Parkinson’s disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson’s disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months ± 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 ≥ 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 ± 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 ± 13 to 20.3 ± 16.4; p < 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829–0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422–12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053–1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027–1.113; p < 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer–Lemeshow test, p = 0.665; R 2 = 0.655). An increase in ≥5 and ≥10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663–17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975–22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.Mir P. has received honoraria from AbbVie, Abbott, Allergan, Bial, Merz, UCB and Zambon and have received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [PI-0437-2012, PI-0471-2013], the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, the Fundación Mutua Madrileña.Peer reviewe

COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied

Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life

Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL: 1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05 +/- 7.84 years old; 59% males) were included. MNCD stage was: stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advanced MNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p < 0.0001) and EUROHIS-QOL8 (p < 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD