Design of Intervention Program for Preventing of Alcohol Misuse in University Students

In the Universidad de Oriente of Santiago de Cuba, recent diagnoses showed there is currently an increase in the rate of young people who consume alcoholic beverages. Therefore, the present research has like General Objective: To design a psychoeducational intervention program to prevent the undue consumption of alcohol in the Student Residence of the University of the East of Santiago de Cuba. Techniques such as Composition, Risk Perception Questionnaire on Alcohol Consumption, Social Skills Questionnaire and Preference Questionnaire for leisure time have used. The main results were that 94% of these young people had a low perception of risk on alcohol consumption and only 15% were able to identify the main negative consequences associated with consumption. 96% had insufficient development of social skills, which is associated with the poor ability to resist the pressure of the group

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review

A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on individual observations. A standard integration task in cancer studies is to identify altered genomic regions that induce changes in the expression of the associated genes based on joint analysis of genome-wide gene expression and copy number profiling measurements. In this review, we provide a comparison among various modeling procedures for integrating genome-wide profiling data of gene copy number and transcriptional alterations and highlight common approaches to genomic data integration. A transparent benchmarking procedure is introduced to quantitatively compare the cancer gene prioritization performance of the alternative methods. The benchmarking algorithms and data sets are available at http://intcomp.r-forge.r-project.orgComment: PDF file including supplementary material. 9 pages. Preprin

Sicole: diagnóstico y tratamiento computarizado de la dislexia en español

En este articulo realizamos un recorrido sobre las investigaciones más relevantes en el campo de la tecnología aplicada al diseño instruccional, las cuales marcan las pautas de diseño de los programas educativos actuales y presentamos los criterios pedagógicos y tecnológicos que hemos seguido en el diseño e implementación de un ITS para la diagnóstico, evaluación y tratamiento de niños con Dislexia en el lenguaje español. Este trabajo se halla dentro del marco de un proyecto de investigación interdisciplinar titulado SICOLE, formado por psicólogos, pedagogos e informáticos.In this paper we present the most significant researchers in the area of technology applied to instructional design. Also, we describe the pedagogical and technological principles followed in the design and implementation of an Intelligent Tutorial System for assessment and treatment of dyslexic children in Spanish language. This work is result of a multidisciplinary research with engineers, teachers and psychologists and it has been funded by «Fondos Europeos para el Desarrollo Regional» (FEDER), 1FD97-1140, and the «Dirección General de Investigación Científica y Técnica» (DIGICYT). This package has being used in several Spanish schools as part of its validation process

Psychological Intervention for Development of Disease Awareness in Addicts: Villa Colibri Therapeutic Community of Santiago De Cuba

In the research, a Mixed Method was used and the execution was through a sequential exploratory design. For the initial diagnosis was used, semi-structured interview, sentence completion test, disease awareness questionnaire, attitude to the disease, interpersonal relationships, and conflict management, were the dimensions of the awareness indicator of the disease. Based on the results of the diagnosis, the Psychological Intervention Program was developed, based on the cognitive-behavioral model with a humanistic approach. with respect to the attitude towards the disease, the subjects predominated in ambivalence in 70.6% and non-consciousness in 23.5%, referring to interpersonal relationships, ambivalent in 58.8% and not healthy in 29.4% and conflict management was inconsistent in 70.6%, and inadequate in 23.5%, after the development of the program, positive attitude increased 52.9% and ambivalence decreased to 41.2%, healthy interpersonal relationships grew to 47.1% and adequate conflict management was imposed in 58.8% of the sample. The lack of awareness of the disease in patients was identified, the preliminary results of the application of the program proved to be very useful to develop awareness of the disease in the subjects studied, thus achieving a better therapeutic adherence

Current Approaches and Controversies: Legalization and Non-legalization of Drugs

When a critical analysis to date has made of, the historical aspects related to the topic of drugs, we could distinguish the existence of contrary positions regarding the possibility of legalizing them or not legalizing them. This dilemma is a very topical and important issue since opting for one position or another has economic, political and social implications that are necessary to keep track of. Therefore, the present study aims to; evaluate the advantages and disadvantages that would imply the legalization and non-legalization of drugs. Scientific journals from five years ago have consulted to date, theses and dissertations on the subject, digital and printed books that appear in libraries. Personal communication has made with researchers in the area of ​​addictions. The main results were that the legalization of drugs is very dangerous for society due to its highly addictive and harmful effects on human beings. Likewise, specialists in addictions affirm that legalization can send the wrong message that consuming marijuana and other illegal drugs does not represent risks, which in turn can generate the wrong perception of safety and promote the promotion of consumption. In conclusion, the legalization would not mean the disappearance of the current drug lords, since prices would fall, but this would have compensated with a higher demand, which would increase the sales-consumption volume

New variable separation approach: application to nonlinear diffusion equations

The concept of the derivative-dependent functional separable solution, as a generalization to the functional separable solution, is proposed. As an application, it is used to discuss the generalized nonlinear diffusion equations based on the generalized conditional symmetry approach. As a consequence, a complete list of canonical forms for such equations which admit the derivative-dependent functional separable solutions is obtained and some exact solutions to the resulting equations are described.Comment: 19 pages, 2 fig

Meat processing and colon carcinogenesis: Cooked, nitrite-treated and oxidized high-heme cured meat promotes mucin depleted foci in rats

Processed meat intake is associated with colorectal cancer risk, but no experimental study supports the epidemiologic evidence. To study the effect of meat processing on carcinogenesis promotion, we first did a 14-day study with 16 models of cured meat. Studied factors, in a 2 × 2 × 2 × 2 design, were muscle color (a proxy for heme level), processing temperature, added nitrite, and packaging. Fischer 344 rats were fed these 16 diets, and we evaluated fecal and urinary fat oxidation and cytotoxicity, three biomarkers of heme-induced carcinogenesis promotion. A principal component analysis allowed for selection of four cured meats for inclusion into a promotion study. These selected diets were given for 100 days to rats pretreated with 1,2-dimethylhydrazine. Colons were scored for preneoplastic lesions: aberrant crypt foci (ACF) and mucin-depleted foci (MDF). Cured meat diets significantly increased the number of ACF/colon compared with a no-meat control diet (P = 0.002). Only the cooked nitrite-treated and oxidized high heme meat significantly increased the fecal level of apparent total N-nitroso compounds (ATNC) and the number of MDF per colon compared with the no-meat control diet (P < 0.05). This nitrite-treated and oxidized cured meat specifically increased the MDF number compared with similar non nitrite-treated meat (P = 0.03) and with similar non oxidized meat (P = 0.004). Thus, a model cured meat, similar to ham stored aerobically, increased the number of preneoplastic lesions, which suggests colon carcinogenesis promotion. Nitrite treatment and oxidation increased this promoting effect, which was linked with increased fecal ATNC level. This study could lead to process modifications to make non promoting processed meat