1,159 research outputs found
JAK2V617F-homozigosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant clone
Te covered Si(001): a variable surface reconstruction
At a given temperature, clean and adatom covered silicon surfaces usually
exhibit well-defined reconstruction patterns. Our finite temperature ab-initio
molecular dynamics calculations show that the tellurium covered Si(001) surface
is an exception. Soft longitudinal modes of surface phonons due to the strongly
anharmonic potential of the bridged tellurium atoms prevent the reconstruction
structure from attaining any permanent, two dimensional periodic geometry. This
explains why experiments attempting to find a definite model for the
reconstruction have reached conflicting conclusions.Comment: 4 pages, 3 gif figure
Clinical and disease characteristics from REVEAL at time of enrollment (baseline): Prospective observational study of patients with polycythemia vera in the United States
Real-time monitoring of stress evolution during thin film growth by in situ substrate curvature measurement
Strain engineering is the art of inducing controlled lattice distortions in a
material to modify specific physicochemical properties. Strain engineering is
applied for basic fundamental studies of physics and chemistry of solids but
also for device fabrication through the development of materials with new
functionalities. Thin films are one of the most important tools for strain
engineering. Thin films can in fact develop large strain due to the crystalline
constrains at the interface with the substrate and/or as the result of specific
morphological features that can be selected by an appropriate tuning of the
deposition parameters. Within this context, the in situ measurement of the
substrate curvature is a powerful diagnostic tool allowing a real time
monitoring of the stress state of the growing film. This manuscript reviews a
few recent applications of this technique and presents new measurements that
point out the great potentials of the substrate curvature measurement in strain
engineering. Our study also shows how, due to the high sensitivity of the
technique, the correct interpretation of the results can be in certain cases
not trivial and require complementary characterizations and an accurate
knowledge of the physicochemical properties of the materials under
investigation
Surfactant induced smooth and symmetric interfaces in Cu/Co multilayers
In this work we studied Ag surfactant induced growth of Cu/Co multilayers.
The Cu/Co multilayers were deposited using Ag surfactant by ion beam sputtering
technique. It was found that Ag surfactant balances the asymmetry between the
surface free energy of Cu and Co. As a result, the Co-on-Cu and Cu-on-Co
interfaces become sharp and symmetric and thereby improve the thermal stability
of the multilayer. On the basis of obtained results, a mechanism leading to
symmetric and stable interfaces in Cu/Co multilayers is discussed.Comment: 7 Pages, 7 Figure
The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA
Alterations in genetic programs required for terminal myeloid differentiation and aberrant proliferation characterize acute myeloid leukemia (AML) cells. Here, we identify the host transcript of miR-223, linc-223, as a novel functional long non-coding RNA (lncRNA) in AML. We show that from the primary nuclear transcript, the alternative production of miR-223 and linc-223 is finely regulated during monocytic differentiation. Moreover, linc-223 expression inhibits cell cycle progression and promotes monocytic differentiation of AML cells. We also demonstrate that endogenous linc-223 localizes in the cytoplasm and acts as a competing endogenous RNA for miR-125-5p, an oncogenic microRNA in leukemia. In particular, we show that linc-223 directly binds to miR-125-5p and that its knockdown increases the repressing activity of miR-125-5p resulting in the downregulation of its target interferon regulatory factor 4 (IRF4), which it was previously shown to inhibit the oncogenic activity of miR-125-5p in vivo. Furthermore, data from primary AML samples show significant downregulation of linc-223 in different AML subtypes. Therein, these findings indicate that the newly identified lncRNA linc-223 may have an important role in myeloid differentiation and leukemogenesis, at least in part, by cross-talking with IRF4 mRNA
Red-Emitting Tetracoordinate Organoboron Chelates: Synthesis, Photophysical Properties, and Fluorescence Microscopy
Seven tetracoordinate organoboron fluorophores with heterobiaryl N,O- or N,N-chelate ligands were prepared and photophysically characterized (in toluene). The electronic variation of the heteroaromatic moiety provided a means for the fine-tuning of the UV/vis absorption and emission spectra. In the most interesting cases, the spectra were red-shifted to maximum absorbance at wavelengths longer than 500 nm and emission maxima between 620 and 660 nm. The pronounced intramolecular charge-transfer character of the dyes yielded large Stokes shifts (3500-5100 cm), while maintaining appreciable fluorescence quantum yields of up to 0.2 for emission maxima longer than 600 nm. The lipophilic character of the dyes enabled their application as stains of vesicle substructures in confocal fluorescence microscopy imaging.Ministerio de EconomĂa y Competitividad CTQ2014-54729 - C2 - 1 - P for U.P., CTQ2013 - 48164 - C2 - 1 - P , CTQ2013 - 48164 - C2 - 2 - P for A.R., CTQ2013 - 41339 - P, CTQ2015 - 71896 - REDT for E.P.I., RamĂłn y Cajal contract RYC - 2013 - 12585 for A.R.FEDER FundJunta de AndalucĂa 2012/FQM - 2140 for U.P., 2009/FQM - 4537 and 2012/FQM - 1078 for A.R
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