Weakness of shim¡¦s New ID-based tripartite multiple-key agreement protocol

In this article we show that Shim¡¦s new ID-based tripartite multiple-key agreement protocol still suffers from the impersonation attack, a malicious user can launch an impersonation attack on their protocol

Cryptographic Schemes based on Elliptic Curve Pairings

This thesis introduces the concept of certificateless public key cryptography (CLPKC). Elliptic curve pairings are then used to make concrete CL-PKC schemes and are also used to make other efficient key agreement protocols. CL-PKC can be viewed as a model for the use of public key cryptography that is intermediate between traditional certificated PKC and ID-PKC. This is because, in contrast to traditional public key cryptographic systems, CL-PKC does not require the use of certificates to guarantee the authenticity of public keys. It does rely on the use of a trusted authority (TA) who is in possession of a master key. In this respect, CL-PKC is similar to identity-based public key cryptography (ID-PKC). On the other hand, CL-PKC does not suffer from the key escrow property that is inherent in ID-PKC. Applications for the new infrastructure are discussed. We exemplify how CL-PKC schemes can be constructed by constructing several certificateless public key encryption schemes and modifying other existing ID based schemes. The lack of certificates and the desire to prove the schemes secure in the presence of an adversary who has access to the master key or has the ability to replace public keys, requires the careful development of new security models. We prove that some of our schemes are secure, provided that the Bilinear Diffie-Hellman Problem is hard. We then examine Joux’s protocol, which is a one round, tripartite key agreement protocol that is more bandwidth-efficient than any previous three-party key agreement protocol, however, Joux’s protocol is insecure, suffering from a simple man-in-the-middle attack. We show how to make Joux’s protocol secure, presenting several tripartite, authenticated key agreement protocols that still require only one round of communication. The security properties of the new protocols are studied. Applications for the protocols are also discussed

Pairing-based cryptosystems and key agreement protocols.

For a long time, pairings on elliptic curves have been considered to be destructive in elliptic curve cryptography. Only recently after some pioneering works, particularly the well-known Boneh-Franklin identity-based encryption (IBE), pairings have quickly become an important tool to construct novel cryptographic schemes. In this thesis, several new cryptographic schemes with pairings are proposed, which are both efficient and secure with respect to a properly defined security model, and some relevant previous schemes are revisited. IBE provides a public key encryption mechanism where a public key can be an arbitrary string such as an entity identifier and unwieldy certificates are unnecessary. Based on the Sakai-Kasahara key construction, an IBE scheme which is secure in the Boneh-Franklin IBE model is constructed, and two identity-based key encapsulation mechanisms are proposed. These schemes achieve the best efficiency among the existing schemes to date. Recently Al-Riyami and Paterson introduced the certificateless public key encryption (CL-PKE) paradigm, which eliminates the need of certificates and at the same time retains the desirable properties of IBE without the key escrow problem. The security formulation of CL-PKE is revisited and a strong security model for this type of mechanism is defined. Following a heuristic approach, three efficient CL-PKE schemes which are secure in the defined strong security model are proposed. Identity-based two-party key agreement protocols from pairings are also investigated. The Bellare-Rogaway key agreement model is enhanced and within the model several previously unproven protocols in the literature are formally analysed. In considering that the user identity may be sensitive information in many environments, an identity-based key agreement protocol with unilateral identity privacy is proposed

Pairing-based cryptosystems and key agreement protocols

For a long time, pairings on elliptic curves have been considered to be destructive in elliptic curve cryptography. Only recently after some pioneering works, particularly the well-known Boneh-Franklin identity-based encryption (IBE), pairings have quickly become an important tool to construct novel cryptographic schemes. In this thesis, several new cryptographic schemes with pairings are proposed, which are both efficient and secure with respect to a properly defined security model, and some relevant previous schemes are revisited. IBE provides a public key encryption mechanism where a public key can be an arbitrary string such as an entity identifier and unwieldy certificates are unnecessary. Based on the Sakai-Kasahara key construction, an IBE scheme which is secure in the Boneh-Franklin IBE model is constructed, and two identity-based key encapsulation mechanisms are proposed. These schemes achieve the best efficiency among the existing schemes to date. Recently Al-Riyami and Paterson introduced the certificateless public key encryption (CL-PKE) paradigm, which eliminates the need of certificates and at the same time retains the desirable properties of IBE without the key escrow problem. The security formulation of CL-PKE is revisited and a strong security model for this type of mechanism is defined. Following a heuristic approach, three efficient CL-PKE schemes which are secure in the defined strong security model are proposed. Identity-based two-party key agreement protocols from pairings are also investigated. The Bellare-Rogaway key agreement model is enhanced and within the model several previously unproven protocols in the literature are formally analysed. In considering that the user identity may be sensitive information in many environments, an identity-based key agreement protocol with unilateral identity privacy is proposed.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Despite worldwide prescription, the mechanistic basis for superiority of second-generation HIV integrase (IN) strand transfer inhibitors (INSTIs) is poorly understood. We use single-particle cryo-electron microscopy to visualize the mode of action of the advanced INSTIs dolutegravir and bictegravir at near atomic resolution. Q148H/G140S amino acid substitutions in IN that pervade clinical INSTI failure perturb optimal magnesium ion coordination in the enzyme active site. The expanded chemical scaffolds of second-generation compounds mediate interactions with the protein backbone, which are critical for antagonizing Q148H/G140S mutant virus. Our results reveal that binding to magnesium ions underpins a fundamental weakness of the INSTI pharmacophore that is exploited by the virus to engender resistance and provide a structural framework for the development of this important class of anti-HIV/AIDS therapeutics

Genetic mapping of metabolic biomarkers of cardiometabolic diseases

Cardiometabolic disorders (CMDs) are a major public health problem worldwide. The main goal of this thesis is to characterize the genetic architecture of CMD-related metabolites in a Lebanese cohort. In order to maximise the extraction of meaningful biological information from this dataset, an important part of this thesis focuses on the evaluation and subsequent improvement of the standard methods currently used for molecular epidemiology studies. First, I describe MetaboSignal, a novel network-based approach to explore the genetic regulation of the metabolome. Second, I comprehensively compare the recovery of metabolic information in the different 1H NMR strategies routinely used for metabolic profiling of plasma (standard 1D, spin-echo and JRES). Third, I describe a new method for dimensionality reduction of 1H NMR datasets prior to statistical modelling. Finally, I use all this methodological knowledge to search for molecular biomarkers of CMDs in a Lebanese population. Metabolome-wide association analyses identified a number of metabolites associated with CMDs, as well as several associations involving N-glycan units from acute-phase glycoproteins. Genetic mapping of these metabolites validated previously reported gene-metabolite associations, and revealed two novel loci associated with CMD-related metabolites. Collectively, this work contributes to the ongoing efforts to characterize the molecular mechanisms underlying complex human diseases.Open Acces