Requirements for contractility in disordered cytoskeletal bundles

Actomyosin contractility is essential for biological force generation, and is well understood in highly organized structures such as striated muscle. Additionally, actomyosin bundles devoid of this organization are known to contract both in vivo and in vitro, which cannot be described by standard muscle models. To narrow down the search for possible contraction mechanisms in these systems, we investigate their microscopic symmetries. We show that contractile behavior requires non-identical motors that generate large enough forces to probe the nonlinear elastic behavior of F-actin. This suggests a role for filament buckling in the contraction of these bundles, consistent with recent experimental results on reconstituted actomyosin bundles.Comment: 10 pages, 6 figures; text shortene

Local versus global equilibration near the bosonic Mott-superfluid transition

We study the response of trapped two dimensional cold bosons to time dependent lattices. We find that in lattice ramps from 11 (superfluid, $\hbar/U_{\text{i}} = 3$ms, $\hbar/J_{\text{i}} = 45$ms) to 16 recoils (Mott, $\hbar/U_{\text{f}} = 2$ms, $\hbar/J_{\text{f}} = 130$ms) the local number fluctuations remains at their equilibrium values if ramps are slower than 3 ms. Global transport, however, is much slower (1s), especially in the presence of Mott shells. This separation of timescales has practical implications for cold atom experiments and cooling protocols.Comment: 4 pages, 4 figs. 6 subfigure

How a Diverse Research Ecosystem Has Generated New Rehabilitation Technologies: Review of NIDILRR’s Rehabilitation Engineering Research Centers

Over 50 million United States citizens (1 in 6 people in the US) have a developmental, acquired, or degenerative disability. The average US citizen can expect to live 20% of his or her life with a disability. Rehabilitation technologies play a major role in improving the quality of life for people with a disability, yet widespread and highly challenging needs remain. Within the US, a major effort aimed at the creation and evaluation of rehabilitation technology has been the Rehabilitation Engineering Research Centers (RERCs) sponsored by the National Institute on Disability, Independent Living, and Rehabilitation Research. As envisioned at their conception by a panel of the National Academy of Science in 1970, these centers were intended to take a “total approach to rehabilitation”, combining medicine, engineering, and related science, to improve the quality of life of individuals with a disability. Here, we review the scope, achievements, and ongoing projects of an unbiased sample of 19 currently active or recently terminated RERCs. Specifically, for each center, we briefly explain the needs it targets, summarize key historical advances, identify emerging innovations, and consider future directions. Our assessment from this review is that the RERC program indeed involves a multidisciplinary approach, with 36 professional fields involved, although 70% of research and development staff are in engineering fields, 23% in clinical fields, and only 7% in basic science fields; significantly, 11% of the professional staff have a disability related to their research. We observe that the RERC program has substantially diversified the scope of its work since the 1970’s, addressing more types of disabilities using more technologies, and, in particular, often now focusing on information technologies. RERC work also now often views users as integrated into an interdependent society through technologies that both people with and without disabilities co-use (such as the internet, wireless communication, and architecture). In addition, RERC research has evolved to view users as able at improving outcomes through learning, exercise, and plasticity (rather than being static), which can be optimally timed. We provide examples of rehabilitation technology innovation produced by the RERCs that illustrate this increasingly diversifying scope and evolving perspective. We conclude by discussing growth opportunities and possible future directions of the RERC program

Predictive text entry in immersive environments

One of the classic problems with immersive environments is data entry; with a head-mounted display (HMD) the user can no longer see the keyboard. Although for many applications data entry is not a requirement, for some it is essential: communicating in collaborative environments, entering a filename to which work can be saved, or accessing system controls. Combining data gloves and a graphically represented keyboard with a predictive spelling paradigm, we describe an effective text entry technique for immersive environments; we explore the key issues when using such a technique, and report the results of preliminary usability testing

Tackling Challenges in Seebeck Coefficient Measurement of Ultra-High Resistance Samples with an AC Technique

Seebeck coefficient is a widely studied semiconductor property. Conventional Seebeck coefficient measurements are based on DC voltage measurement. Normally this is performed on samples with moderate resistances (e.g., below a few MΩ level). Certain semiconductors are intrinsic and highly resistive. Many examples can be found in optical and photovoltaic materials. The hybrid halide perovskites that have gained extensive attention recently are a good example. Despite great attention from the materials and physics communities, few successful studies exist of the Seebeck coefficient of these compounds, for example CH3NH3PbI3. An AC-technique-based Seebeck coefficient measurement is reported, which makes high-quality Seebeck voltage measurements on samples with resistances up to the 100 GΩ level. This is achieved through a specifically designed setup to enhance sample isolation and increase capacitive impedance. As a demonstration, Seebeck coefficient measurement of a CH3NH3PbI3 thin film is performed at dark, with sample resistance 150 GΩ, and found S = +550 µV K−1. The strategy reported could be applied to the studies of fundamental transport parameters of all intrinsic semiconductors that have not been feasible

On the interpretation of the apparent existence of a preferred magnetic polarity in extragalactic jet sources

Contopoulos et al. recently argued that there is observational evidence for a preferred sense of the Faraday rotation-measure gradients across jets from active galactic nuclei (AGNs). Such behaviour could arise if there were a deterministic relationship between the polarity of the poloidal magnetic field that threads the outflow and the sense of rotation of the outflow's source. Based on this interpretation, Countopoulos et al. suggested that their finding supports a model for the origin of cosmic magnetic fields in a Poynting-Robertson process operating in AGN accretion discs. Here I point out that an alternative explanation of such a relationship could be that the Hall current plays a key role in the magnetohydrodynamics of the underlying disc. In this picture, the measured Faraday rotation is dominated by the contribution of a centrifugally driven wind that is launched from the weakly ionized outer region of the disc. Additional observations are, however, needed to verify the claimed behaviour.Comment: 5 pages, 1 figure, to appear in MNRAS (Letters

Integration of virtual reality within the built environment curriculum

Virtual Reality (VR) technology is still perceived by many as being inaccessible and cost prohibitive with VR applications considered expensive to develop as well as challenging to operate. This paper reflects on current developments in VR technologies and describes an approach adopted for its phased integration into the academic curriculum of built environment students. The process and end results of implementing the integration are discussed and the paper illustrates the challenges of introducing VR, including the acceptance of the technology by academic staff and students, interest from industry, and issues pertaining to model development. It sets out to show that fairly sophisticated VR models can now be created by non-VR specialists using commercially available software and advocates that the implementation of VR will increase alongside industryis adoption of these tools and the emergence of a new generation of students with VR skills. The study shows that current VR technologies, if integrated appropriately within built environment academic programmes, demonstrate clear promise to provide a foundation for more widespread collaborative working environments