Asynchronous Circuits as an Enabler of Scalable And Programmable Metasurfaces

Metamaterials and metasurfaces have given possibilities for manipulating electromagnetic (EM) waves that in the past would have seemed impossible. The majority of metasurface designs are suitable for a particular frequency and angle of incidence. One long-sought objective is the design of programmable metasurfaces to dynamically manipulate a variety of incoming EM frequencies and angles. In order to do this, a large-scale mesh of networked chips are required below the metasurface, which apart from adapting electrical impedance properties, also communicate with each other, thus relaying information about meta-atom settings, as well as forwarding possible distributed measurements taken. This paper describes why an asynchronous mixed-signal ASIC is advantageous for the control of scalable, EM absorbing, metasurfaces

A WI-FI BASED SMART DATA LOGGER FOR CAPSULE ENDOSCOPY AND MEDICAL APPLICATIONS

Wireless capsule endoscopy (WCE) is a non-invasive technology for capturing images of a human digestive system for medical diagnostics purpose. With WCE, the patient swallows a miniature capsule with camera, data processing unit, RF transmitter and batteries. The capsule captures and transmits images wirelessly from inside the human gastrointestinal (GI) tract. The external data logger worn by the patient stores the images and is later on transferred to a computer for presentation and image analysis. In this research, we designed and built a Wi-Fi based, low cost, miniature, versatile wearable data logger. The data logger is used with Wi-Fi enabled smart devices, smart phones and data servers to store and present images captured by capsule. The proposed data logger is designed to work with wireless capsule endoscopy and other biosensors like- temperature and heart rate sensors. The data logger is small enough to carry and conduct daily activities, and the patient do not need to carry traditional bulky data recorder all the time during diagnosis. The doctors can remotely access data and analyze the images from capsule endoscopy using remote access feature of the data logger. Smartphones and tablets have extensive processing power with expandable memory. This research exploits those capabilities to use with wireless capsule endoscopy and medical data logging applications. The application- specific data recorders are replaced by the proposed Wi-Fi data logger and smartphone. The data processing application is distributed on smart devices like smartphone /tablets and data logger. Once data are stored in smart devices, the data can be accessed remotely, distributed to the cloud and shared within networks to enable telemedicine. The data logger can work in both standalone and network mode. In the normal mode of the device, data logger stores medical data locally into a micro Secure Digital card for future download using the universal serial bus to the computer. In network mode, the real-time data is streamed into a smartphone and tablet for further processing and storage. The proposed Wi-Fi based data logger is prototyped in the lab and tested with the capsule hardware developed in our laboratory. The supporting Android app is also developed to collect data from the data logger and present the processed data to the viewer. The PC based software is also developed to access the data recorder and capture and download data from the data logger in real-time remotely. Both in vivo and ex vivo trials using live pig have been conducted to validate the performance of the proposed device

Modulation Techniques for Biomedical Implanted Devices and Their Challenges

Implanted medical devices are very important electronic devices because of their usefulness in monitoring and diagnosis, safety and comfort for patients. Since 1950s, remarkable efforts have been undertaken for the development of bio-medical implanted and wireless telemetry bio-devices. Issues such as design of suitable modulation methods, use of power and monitoring devices, transfer energy from external to internal parts with high efficiency and high data rates and low power consumption all play an important role in the development of implantable devices. This paper provides a comprehensive survey on various modulation and demodulation techniques such as amplitude shift keying (ASK), frequency shift keying (FSK) and phase shift keying (PSK) of the existing wireless implanted devices. The details of specifications, including carrier frequency, CMOS size, data rate, power consumption and supply, chip area and application of the various modulation schemes of the implanted devices are investigated and summarized in the tables along with the corresponding key references. Current challenges and problems of the typical modulation applications of these technologies are illustrated with a brief suggestions and discussion for the progress of implanted device research in the future. It is observed that the prime requisites for the good quality of the implanted devices and their reliability are the energy transformation, data rate, CMOS size, power consumption and operation frequency. This review will hopefully lead to increasing efforts towards the development of low powered, high efficient, high data rate and reliable implanted devices

Capsule endoscopy system with novel imaging algorithms

Wireless capsule endoscopy (WCE) is a state-of-the-art technology to receive images of human intestine for medical diagnostics. In WCE, the patient ingests a specially designed electronic capsule which has imaging and wireless transmission capabilities inside it. While the capsule travels through the gastrointestinal (GI) tract, it captures images and sends them wirelessly to an outside data logger unit. The data logger stores the image data and then they are transferred to a personal computer (PC) where the images are reconstructed and displayed for diagnosis. The key design challenge in WCE is to reduce the area and power consumption of the capsule while maintaining acceptable image reconstruction. In this research, the unique properties of WCE images are identified by analyzing hundreds of endoscopic images and video frames, and then these properties are used to develop novel and low complexity compression algorithms tailored for capsule endoscopy. The proposed image compressor consists of a new YEF color space converter, lossless prediction coder, customizable chrominance sub-sampler and an efficient Golomb-Rice encoder. The scheme has both lossy and lossless modes and is further customized to work with two lighting modes – conventional white light imaging (WLI) and emerging narrow band imaging (NBI). The average compression ratio achieved using the proposed lossy compression algorithm is 80.4% for WBI and 79.2% for NBI with high reconstruction quality index for both bands. Two surveys have been conducted which show that the reconstructed images have high acceptability among medical imaging doctors and gastroenterologists. The imaging algorithms have been realized in hardware description language (HDL) and their functionalities have been verified in field programmable gate array (FPGA) board. Later it was implemented in a 0.18 μm complementary metal oxide semiconductor (CMOS) technology and the chip was fabricated. Due to the low complexity of the core compressor, it consumes only 43 µW of power and 0.032 mm2 of area. The compressor is designed to work with commercial low-power image sensor that outputs image pixels in raster scan fashion, eliminating the need of significant input buffer memory. To demonstrate the advantage, a prototype of the complete WCE system including an FPGA based electronic capsule, a microcontroller based data logger unit and a Windows based image reconstruction software have been developed. The capsule contains the proposed low complexity image compressor and can generate both lossy and lossless compressed bit-stream. The capsule prototype also supports both white light imaging (WLI) and narrow band imaging (NBI) imaging modes and communicates with the data logger in full duplex fashion, which enables configuring the image size and imaging mode in real time during the examination. The developed data logger is portable and has a high data rate wireless connectivity including Bluetooth, graphical display for real time image viewing with state-of-the-art touch screen technology. The data are logged in micro SD cards and can be transferred to PC or Smartphone using card reader, USB interface, or Bluetooth wireless link. The workstation software can decompress and show the reconstructed images. The images can be navigated, marked, zoomed and can be played as video. Finally, ex-vivo testing of the WCE system has been done in pig's intestine to validate its performance

Magneto inductive communication system for underwater wireless sensor networks

Underwater wireless sensor networks have found a number of applications in underwater environment monitoring, infrastructure monitoring, military applications and ocean exploration. Among the four possible means of underwater wireless communication, namely acoustic, electromagnetic (EM), magneto-inductive (MI) and optics communication, MI communication enjoys the advantages of being low cost and robust equally in air, water and soil. This dissertation presents design and implementation of a low-power and low-cost MI sensor network node that is suited for long-term deployment of underwater and underground infrastructure monitoring, such as bridge scour and levee scour monitoring. The designed MI sensor node combat the directionality of the single coil MI communication by utilizing 3D coil to both transmit and receive. The presented MI sensor node is tested in air and underwater to show robustness and reliability. The sensor node is designed after thorough analysis and evaluation of various MI challenges such as directionality, short range, decoupling due to mis-alignment of coils, and effect of metal structure. A communication range of 40 m has been achieved by the prototype sensor node. The prototyping cost of a sensor node is less than US$100 and will be drastically reduced at volume production. A novel and an energy efficient medium access control (MAC) protocol based on the carrier sense medium access (CSMA) has also been implemented for the designed sensor node to improve throughput in a dense network --Abstract, page iv

Design, manufacturing and characterisation of a wireless flexible pressure sensor system for the monitoring of the gastro-intestinal tract

Ingestible motility capsule (IMC) endoscopy holds a strong potential in providing advanced diagnostic capabilities within the small intestine with higher patient tolerance for pathologies such as irritable bowel syndrome, gastroparesis and chronic abdominal amongst others. Currently state-of-the art IMCs are limited by the use of obstructive off-the-shelf sensing modules that are unable to provide multi-site tactile monitoring of the Gastro-Intestinal tract. In this work a novel 12 mm in diameter by 30 mm in length IMC is presented that utilises custom-built flexible, thin-film, biocompatible, wireless and highly sensitive tactile pressure sensors arrays functionalising the capsule shell. The 150 μm thick, microstructured, PDMS flexible passive pressure sensors are wirelessly powered and interrogated, and are capable of detecting pressure values ranging from 0.1 kPa up to 30 kPa with a 0.1 kPa resolution. A novel bottom-up wafer-scale microfabrication process is presented which enables the development of these ultra-dense, self-aligned, scalable and uniquely addressable flexible wireless sensors with high yield (>80%). This thesis also presents an innovative metallisation microfabrication process on soft-elastomeric substrates capable to withstand without failure of the tracks 180o bending, folding and iterative deformation such as to allow conformable mapping of these sensors. A custom-built and low-cost reflectometer system was also designed, built and tested within the capsule that can provide a fast (100 ms) and accurate extraction (±0.1 kPa) of their response. In vitro and in vivo characterisation of the developed IMC device is also presented, facilitated respectively via the use of a biomimetic phantom gut and via live porcine subjects. The capsule device was found to successfully capture respiration, low-amplitude and peristaltic motility of the GI tract from multiple sites of the capsule.UK Engineering & Physical Sciences Research Council (EPSRC) through the Programme Grant Sonopill (EP/K034537/2)James Watt Scholarshi

Telecommunications and other electronic subsystems of ingestible capsule devices

Ingestible and implantable electronics are devices designed for applications that are utilised to improve patients’ health outcomes by helping in prevention, diagnosis and monitoring of disorders. In their operation, ingestible and implantable devices produce large amounts of data that should be collected continuously and exchanged via radio communication. A major challenge for this communication is the mitigation of data loss. This PhD research addresses different aspects of this challenge by exploring a) the feasibility of Bluetooth in ingestible devices, b) improving the design of 433 MHz antennas for ingestible devices, and c) also on a relevant topic about ingestible and implantable sensors, studying the sensing of multiple gases with temperature modulated single-element gas sensors. The feasibility of Bluetooth is explored through developing a custom Bluetooth device for assessing the signal attenuation of transmissions from standard Bluetooth devices which was tested for a variety of human tissue analogues to imitate their dielectric properties and measure propagation losses. It was revealed that the signal attenuation through the tissues could be tolerated up to around 85 mm and that Bluetooth devices are deemed to be viable for such communications. In the next stage of this PhD thesis, a 433 MHz meandering pattern antenna was designed that could be placed into standard ingestible capsules. This work involved the simulations and measurements of different designs and focused on analysing the antenna return losses and gain patterns under different ambient dielectric conditions. The effect of battery location relative to the antenna patterns was also explored. The acquired data suggested that an optimal design could be obtained that could tolerate the very large shift in dielectric conditions present in different segments of the gut. The data provides a broad perspective regarding the design of meandering antennas for ingestible and implantable devices. In the final stage of this PhD thesis, a temperature modulated single-element gas sensing system was developed to study how the technique of temperature modulation could be implemented for measuring and differentiating multiple gases simultaneously. Using single-element gas sensors reduces the footprint of the sensor electronics, providing more space for communications electronics in ingestible devices. The system was tested for H2 and H2S sensing. The outcomes demonstrated that the technique was feasible and showed the practicality of using signal processing techniques in gas sensing systems. The work presented in this PhD research added to the body of knowledge in the fields of ingestible and implantable sensing devices

Platforms for prototyping minimally invasive instruments

The introduction of new technologies in medicine is often an issue because there are many stages to go through, from the idea to the approval by ethical committees and mass production. This work covers the first steps of the development of a medical device, dealing with the tools that can help to reduce the time for producing the laboratory prototype. These tools can involve electronics and software for the creation of a “universal”' hardware platform that can be used for many robotic applications, adapting only few components for the specific scenario. The platform is created by setting up a traditional computer with operating system and acquisition channels aimed at opening the system toward the real environment. On this platform algorithms can be implemented rapidly, allowing to assess the feasibility of an idea. This approach lets the designer concentrate on the application rather than on the selection of the appropriate hardware electronics every time that a new project starts. In the first part an overview of the existing instruments for minimally invasive interventions that can be found as commercial or research products is given. An introduction related to hardware electronics is presented with the requirements and the specific characteristics needed for a robotic application. The second part focuses on specific projects in MIS. The first project concerns the study and the development of a lightweight hand-held robotic instrument for laparoscopy. Motivations are related to the lack of dexterous hand-held laparoscopic instruments. The second project concerns the study and the presentation of a prototype of a robotic endoscope with enhanced resolution. The third project concerns the development of a system able to detect the inspiration and the expiration phases. The aim is to evaluate the weariness of the surgeon, since breathing can be related to fatigue

VLSI Design

This book provides some recent advances in design nanometer VLSI chips. The selected topics try to present some open problems and challenges with important topics ranging from design tools, new post-silicon devices, GPU-based parallel computing, emerging 3D integration, and antenna design. The book consists of two parts, with chapters such as: VLSI design for multi-sensor smart systems on a chip, Three-dimensional integrated circuits design for thousand-core processors, Parallel symbolic analysis of large analog circuits on GPU platforms, Algorithms for CAD tools VLSI design, A multilevel memetic algorithm for large SAT-encoded problems, etc

Front-end receiver for miniaturised ultrasound imaging

Point of care ultrasonography has been the focus of extensive research over the past few decades. Miniaturised, wireless systems have been envisaged for new application areas, such as capsule endoscopy, implantable ultrasound and wearable ultrasound. The hardware constraints of such small-scale systems are severe, and tradeoffs between power consumption, size, data bandwidth and cost must be carefully balanced. To address these challenges, two synthetic aperture receiver architectures are proposed and compared. The architectures target highly miniaturised, low cost, B-mode ultrasound imaging systems. The first architecture utilises quadrature (I/Q) sampling to minimise the signal bandwidth and computational load. Synthetic aperture beamforming is carried out using a single-channel, pipelined protocol in order to minimise system complexity and power consumption. A digital beamformer dynamically apodises and focuses the data by interpolating and applying complex phase rotations to the I/Q samples. The beamformer is implemented on a Spartan-6 FPGA and consumes 296mW for a frame rate of 7Hz. The second architecture employs compressive sensing within the finite rate of innovation (FRI) framework to further reduce the data bandwidth. Signals are sampled below the Nyquist frequency, and then transmitted to a digital back-end processor, which reconstructs I/Q components non-linearly, and then carries out synthetic aperture beamforming. Both architectures were tested in hardware using a single-channel analogue front-end (AFE) that was designed and fabricated in AMS 0.35μm CMOS. The AFE demodulates RF ultrasound signals sequentially into I/Q components, and comprises a low-noise preamplifier, mixer, programmable gain amplifier (PGA) and lowpass filter. A variable gain low noise preamplifier topology is used to enable quasi-exponential time-gain control (TGC). The PGA enables digital selection of three gain values (15dB, 22dB and 25.5dB). The bandwidth of the lowpass filter is also selectable between 1.85MHz, 510kHz and 195kHz to allow for testing of both architectural frameworks. The entire AFE consumes 7.8 mW and occupies an area of 1.5×1.5 mm. In addition to the AFE, this thesis also presents the design of a pseudodifferential, log-domain multiplier-filter or “multer” which demodulates low-RF signals in the current-domain. This circuit targets high impedance transducers such as capacitive micromachined ultrasound transducers (CMUTs) and offers a 20dB improvement in dynamic range over the voltage-mode AFE. The bandwidth is also electronically tunable. The circuit was implemented in 0.35μm BiCMOS and was simulated in Cadence; however, no fabrication results were obtained for this circuit. B-mode images were obtained for both architectures. The quadrature SAB method yields a higher image SNR and 9% lower root mean squared error with respect to the RF-beamformed reference image than the compressive SAB method. Thus, while both architectures achieve a significant reduction in sampling rate, system complexity and area, the quadrature SAB method achieves better image quality. Future work may involve the addition of multiple receiver channels and the development of an integrated system-on-chip.Open Acces