239,076 research outputs found
S. JoĂŁo de Loure Bridge: vulnerability assessment and study of a common strengthening solution
This paper presents a structural vulnerability assessment of the steel bridge S. JoĂŁo de Loure. A structural model of the bridge was created and the influence of the jointâs stiffness on its structural response was evaluated using the structural analysis software SAP2000. Natural frequencies, axial forces and corresponding stress, and maximum mid-span deflection, were analyzed. A common strengthening solution with prestressing cables was studied intending to reduce the bridgeâs mid-span deflection
Vulnerability assessment of the S. JoĂŁo de Loure Bridge: Vougaâs river
Steel bridges are particularly sensible to corrosion, which can put at risk the structural safety by affecting the joint elements. Having this in mind, the objective of this work was to evaluate the influence of the joint's stiffness in the structural response of the S. JoĂŁo de Loure steel bridge. An improved model was developed for the bridge on the structural analysis software SAP2000. Maximum deflection, axial forces and corresponding stresses, and natural frequencies, were analyzed. Numerical results allow concluding about the influence of the joint's stiffness in the structural response of the bridge
The accident risk of motorcyclists
This report contains the findings of a study to explore and quantify the interacting influences which determine motorcyclist accident liabilities. It was conducted on behalf of Road Safety Division, Department for Transport. The study first reviewed existing data sources to investigate the trends in motorcycling accidents over the last decade or so. The main part of the study was to carry out a survey of nearly 30,000 current motorcyclists in order to explore the relationship between accident risk and variables such as annual mileage, age, experience, journey type, training, personal characteristics of the riders, and the self-reported behaviours and attitudes of the riders. The numbers of accidents reported by riders within the past 12-months of riding were modelled using generalised linear techniques to take into account factors such as mileage, age, experience, bike size and the conditions prevailing when they rode. Models of rider behaviour were developed using other statistical modelling techniques. These models investigated how attitudes/motivations/perceptions and rider style influence rider behaviour, and how rider behaviour influences the likelihood of accident involvement. The influence of age, sex and experience on attitudes and behaviours, and as direct or indirect influences on accidents were also investigated. Accident risk was also directly influenced by the number of miles ridden in the past 12-months. The report makes a number of recommendations for improving the safety of motorcycle riders
Liraglutide for the treatment of type 2 diabetes : a single technology appraisal
This paper presents a summary of the Evidence Review Group (ERG) report into the clinical
effectiveness and cost-effectiveness of liraglutide in the treatment of type 2 diabetes mellitus,
based upon the manufacturerâs submission to the National Institute for Health and Clinical
Excellence (NICE) as part of the single technology appraisal (STA) process. The manufacturer
proposed the use of liraglutide as a second or third drug in patients with type 2 diabetes whose
glycaemic control was unsatisfactory with metformin, with or without a second oral glucoselowering
drug. The submission included six manufacturer-sponsored trials that compared the
efficacy of liraglutide against other glucose-lowering agents. Not all of the trials were relevant to the decision problem. The most relevant were Liraglutide Effects and Actions in Diabetes 5
(LEAD-5) (liraglutide used as part of triple therapy and compared against insulin glargine) and
LEAD-6 [liraglutide in triple therapy compared against another glucagon like peptide-1 (GLP-1)
agonist, exenatide]. Five of the six trials were published in full and one was then unpublished.
Two doses of liraglutide, 1.2 and 1.8 mg, were used in some trials but in the two comparisons
in triple therapy, against glargine and exenatide, only the 1.8-mg dose was used. Liraglutide
in both doses was found to be clinically effective in lowering blood glucose concentration
[glycated haemoglobin (HbA1c)], reducing weight (unlike other glucose-lowering agents, such
as sulphonylureas, glitazones and insulins, which cause weight gain) and also reducing systolic
blood pressure (SBP). Hypoglycaemia was uncommon. The ERG carried out meta-analyses
comparing the 1.2- and 1.8-mg doses of liraglutide, which suggested that there was no difference
in control of diabetes, and only a slight difference in weight loss, insufficient to justify the extra
cost
Combined automotive safety and security pattern engineering approach
Automotive systems will exhibit increased levels of automation as well as ever tighter integration with other vehicles, traffic infrastructure, and cloud services. From safety perspective, this can be perceived as boon or bane - it greatly increases complexity and uncertainty, but at the same time opens up new opportunities for realizing innovative safety functions. Moreover, cybersecurity becomes important as additional concern because attacks are now much more likely and severe. However, there is a lack of experience with security concerns in context of safety engineering in general and in automotive safety departments in particular. To address this problem, we propose a systematic pattern-based approach that interlinks safety and security patterns and provides guidance with respect to selection and combination of both types of patterns in context of system engineering. A combined safety and security pattern engineering workflow is proposed to provide systematic guidance to support non-expert engineers based on best practices. The application of the approach is shown and demonstrated by an automotive case study and different use case scenarios.EC/H2020/692474/EU/Architecture-driven, Multi-concern and Seamless Assurance and Certification of Cyber-Physical Systems/AMASSEC/H2020/737422/EU/Secure COnnected Trustable Things/SCOTTEC/H2020/732242/EU/Dependability Engineering Innovation for CPS - DEIS/DEISBMBF, 01IS16043, Collaborative Embedded Systems (CrESt
The attitudes and behaviour of adolescent road users : an application of the theory of planned behaviour
The Theory of Planned Behaviour (TPB) was used as a framework to study the attitudes of adolescent road users towards four target behaviours: (1) cycle helmet use, (2) using nearby crossings, (3) crossing from between parked cars, and (4) challenging traffic. Four questionnaires, one for each of the behaviours, were designed based on pilot work. Each questionnaire contained items to measure the TPB variables, self-reported behaviour, and general exposure and demographic characteristics (e.g. age and gender). A total of 2,457 children aged 11-16 completed the questionnaires; 564 respondents completed the 'cycle helmet use' questionnaire; 657 respondents completed the 'using nearby crossings' questionnaire; 619 respondents completed the 'crossing from between parked cars' questionnaire; and 617 completed the 'challenging traffic' questionnaire. Multivariate analyses were conducted for each of the behaviours to explore how adolescents' attitudes, subjective norms, perceived control, behavioural intentions and self-reported behaviour differed as a function of demographic variables. Correlation and multiple regression analyses were then conducted to test the relationships in the TPB and to identify beliefs underpinning adolescents' attitudes that could be targeted in road safety interventions. This report describes all aspects of the study and discusses the theoretical and practical implications
Cost Estimate Modeling of Transportation Management Plans for Highway Projects, Research Report 11-24
Highway rehabilitation and reconstruction projects frequently cause road congestion and increase safety concerns while limiting access for road users. State Transportation Agencies (STAs) are challenged to find safer and more efficient ways to renew deteriorating roadways in urban areas. To better address the work zone issues, the Federal Highway Administration published updates to the Work Zone Safety and Mobility Rule. All state and local governments receiving federal aid funding were required to comply with the provisions of the rule no later than October 12, 2007. One of the ruleâs major elements is to develop and implement Transportation Management Plans (TMPs). Using well-developed TMP strategies, work zone safety and mobility can be enhanced while road user costs can be minimized. The cost of a TMP for a road project is generally considered a high-cost item and, therefore, must be quantified. However, no tools or systematic modeling methods are available to assist agency engineers with TMP cost estimating. This research included reviewing TMP reports for recent Caltrans projects regarding state-of-the-art TMP practices and input from the district TMP traffic engineers. The researchers collected Caltrans highway project data regarding TMP cost estimating. Then, using Construction Analysis for Pavement Rehabilitation Strategies (CA4PRS) software, the researchers performed case studies. Based on the CA4PRS outcomes of the case studies, a TMP strategy selection and cost estimate (STELCE) model for Caltrans highway projects was proposed. To validate the proposed model, the research demonstrated an application for selecting TMP strategies and estimating TMP costs. Regarding the modelâs limitation, the proposed TMP STELCE model was developed based on Caltrans TMP practices and strategies. Therefore, other STAs might require adjustments and modifications, reflecting their TMP processes, before adopting this model. Finally, the authors recommended that a more detailed step-by-step TMP strategy selection and cost estimate process be included in the TMP guidelines to improve the accuracy of TMP cost estimates
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Effect of alirocumab on lipids and lipoproteins in individuals with metabolic syndrome without diabetes: Pooled data from 10 phase 3 trials.
AimsThis analysis assessed the efficacy and safety of alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, in patients with or without metabolic syndrome (MetS) using pooled data from 10 phase 3 ODYSSEY trials.Materials and methodsData from 4983 randomized patients (1940 with MetS; 1642 with diabetes excluded) were assessed in subgroups by MetS status. Efficacy data were analysed in 4 pools per study design: 2 placebo-controlled pools (1 using alirocumab 150 mg every 2 weeks [Q2W], 1 using 75/150 mg Q2W) with background statin, and 2 ezetimibe-controlled pools (both alirocumab 75/150 mg Q2W), 1 with and 1 without background statin. Alirocumab 75/150 mg indicates possible dose increase from 75 to 150 mg at Week 12 based on Week 8 LDL-C.ResultsLDL-C percentage reduction from baseline at Week 24 with alirocumab was 63.9% (MetS) and 56.8% (non-MetS) in the pool of alirocumab 150 mg Q2W, and 42.2% to 52.2% (MetS) and 45.0% to 52.6% (non-MetS) in 3 pools using 75/150 mg Q2W. Levels of other lipid and lipoprotein parameters were also improved with alirocumab treatment, including apolipoprotein B, non-high-density lipoprotein cholesterol (non-HDL-C), lipoprotein(a) and HDL-C. Overall, the percentage change at Week 24 in LDL-C and other lipids and lipoproteins did not vary by MetS status. Adverse event rates were generally similar between treatment groups, regardless of MetS status; injection-site reactions occurred more frequently in alirocumab vs control groups.ConclusionsAcross study pools, alirocumab-associated reductions in LDL-C, apolipoprotein B, and non-HDL-C were significant vs control, and did not vary by MetS status
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On the use of diverse arguments to increase confidence in dependability claims
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