119,557 research outputs found
Neurons with stereotyped and rapid responses provide a reference frame for relative temporal coding in primate auditory cortex
The precise timing of spikes of cortical neurons relative to stimulus onset carries substantial sensory information. To access this information the sensory systems would need to maintain an internal temporal reference that reflects the precise stimulus timing. Whether and how sensory systems implement such reference frames to decode time-dependent responses, however, remains debated. Studying the encoding of naturalistic sounds in primate (Macaca mulatta) auditory cortex we here investigate potential intrinsic references for decoding temporally precise information. Within the population of recorded neurons, we found one subset responding with stereotyped fast latencies that varied little across trials or stimuli, while the remaining neurons had stimulus-modulated responses with longer and variable latencies. Computational analysis demonstrated that the neurons with stereotyped short latencies constitute an effective temporal reference for relative coding. Using the response onset of a simultaneously recorded stereotyped neuron allowed decoding most of the stimulus information carried by onset latencies and the full spike train of stimulus-modulated neurons. Computational modeling showed that few tens of such stereotyped reference neurons suffice to recover nearly all information that would be available when decoding the same responses relative to the actual stimulus onset. These findings reveal an explicit neural signature of an intrinsic reference for decoding temporal response patterns in the auditory cortex of alert animals. Furthermore, they highlight a role for apparently unselective neurons as an early saliency signal that provides a temporal reference for extracting stimulus information from other neurons
The Decision Value Computations in the vmPFC and Striatum Use a Relative Value Code That is Guided by Visual Attention
There is a growing consensus in behavioral neuroscience that the brain makes simple choices by first assigning a value to the options under consideration and then comparing them. Two important open questions are whether the brain encodes absolute or relative value signals, and what role attention might play in these computations.Weinvestigated these questions using a human fMRI experiment with
a binary choice task in which the fixations to both stimuli were exogenously manipulated to control for the role of visual attention in the valuation computation. We found that the ventromedial prefrontal cortex and the ventral striatum encoded fixation-dependent relative value signals: activity in these areas correlated with the difference in value between the attended and the unattended items. These attention-modulated relative value signals might serve as the input of a comparator system that is used to make a choice
Neuronal evidence for good-based economic decisions under variable action costs
Choices between goods often depend on the action costs, but the mechanisms underlying economic decisions under variable action cost are poorly understood. Here, the authors record from neurons in the monkey orbitofrontal cortex and show that decisions under variable action cost were made in a non-spatial representation
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Wayfinding and Glaucoma: A Virtual Reality Experiment.
PurposeWayfinding, the process of determining and following a route between an origin and a destination, is an integral part of everyday tasks. The purpose of this study was to investigate the impact of glaucomatous visual field loss on wayfinding behavior using an immersive virtual reality (VR) environment.MethodsThis cross-sectional study included 31 glaucomatous patients and 20 healthy subjects without evidence of overall cognitive impairment. Wayfinding experiments were modeled after the Morris water maze navigation task and conducted in an immersive VR environment. Two rooms were built varying only in the complexity of the visual scene in order to promote allocentric-based (room A, with multiple visual cues) versus egocentric-based (room B, with single visual cue) spatial representations of the environment. Wayfinding tasks in each room consisted of revisiting previously visible targets that subsequently became invisible.ResultsFor room A, glaucoma patients spent on average 35.0 seconds to perform the wayfinding task, whereas healthy subjects spent an average of 24.4 seconds (P = 0.001). For room B, no statistically significant difference was seen on average time to complete the task (26.2 seconds versus 23.4 seconds, respectively; P = 0.514). For room A, each 1-dB worse binocular mean sensitivity was associated with 3.4% (P = 0.001) increase in time to complete the task.ConclusionsGlaucoma patients performed significantly worse on allocentric-based wayfinding tasks conducted in a VR environment, suggesting visual field loss may affect the construction of spatial cognitive maps relevant to successful wayfinding. VR environments may represent a useful approach for assessing functional vision endpoints for clinical trials of emerging therapies in ophthalmology
A determination of the radio-planetary frame tie from comparison of Earth orientation parameters
The orientation of the reference frame of radio source catalogs relative to that of planetary ephemerides, or 'frame tie,' can be a major systematic error source for interplanetary spacecraft orbit determination. This work presents a method of determining the radio-planetary frame tie from a comparison of very long baseline interferometry (VLBI) and lunar laser ranging (LLR) station coordinate and earth orientation parameter estimates. A frame tie result is presented with an accuracy of 25 nrad
Multi-scale computational model for failure analysis of metal frames that includes softening and local buckling
In this work we present a new modelling paradigm for computing the complete failure of metal frames by combining the stress-resultant beam model and the shell model. The shell model is used to compute the material parameters that are needed by an inelastic stress-resultant beam model; therefore, we consider the shell model as the meso-scale model and the beam model as the macro-scale model. The shell model takes into account elastoplasticity with strain-hardening and strain-softening, as well as geometrical nonlinearity (including local buckling of a part of a beam). By using results of the shell model, the stress-resultant inelastic beam model is derived that takes into account elastoplasticity with hardening, as well as softening effects (of material and geometric type). The beam softening effects are numerically modelled in a localized failure point by using beam finite element with embedded discontinuity. The original feature of the proposed multi-scale (i.e. shell-beam) computational model is its ability to incorporate both material and geometrical instability contributions into the stress-resultant beam model softening response. Several representative numerical simulations are presented to illustrate a very satisfying performance of the proposed approach
Kinematic frames and "active longitudes": does the Sun have a face?
It has recently been claimed that analysis of Greenwich sunspot data over 120
years reveals that sunspot activity clusters around two longitudes separated by
180 degrees (``active longitudes'') with clearly defined differential rotation
during activity cycles.In the present work we extend this critical examination
of methodology to the actual Greenwich sunspot data and also consider newly
proposed methods of analysis claiming to confirm the original identification of
active longitudes. Our analysis revealed that values obtained for the
parameters of differential rotation are not stable across different methods of
analysis proposed to track persistent active longitudes. Also, despite a very
thorough search in parameter space, we were unable to reproduce results
claiming to reveal the century-persistent active longitudes. We can therefore
say that strong and well substantiated evidence for an essential and
century-scale persistent nonaxisymmetry in the sunspot distribution does not
exist.Comment: 14 pages, 1 table, 21 figures, accepted in A&
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