A transfer learning approach to drug resistance classification in mixed HIV dataset

Funding: This research is funded by the Tertiary Education Trust Fund (TETFund), Nigeria.As we advance towards individualized therapy, the ‘one-size-fits-all’ regimen is gradually paving the way for adaptive techniques that address the complexities of failed treatments. Treatment failure is associated with factors such as poor drug adherence, adverse side effect/reaction, co-infection, lack of follow-up, drug-drug interaction and more. This paper implements a transfer learning approach that classifies patients' response to failed treatments due to adverse drug reactions. The research is motivated by the need for early detection of patients' response to treatments and the generation of domain-specific datasets to balance under-represented classification data, typical of low-income countries located in Sub-Saharan Africa. A soft computing model was pre-trained to cluster CD4+ counts and viral loads of treatment change episodes (TCEs) processed from two disparate sources: the Stanford HIV drug resistant database (https://hivdb.stanford.edu), or control dataset, and locally sourced patients' records from selected health centers in Akwa Ibom State, Nigeria, or mixed dataset. Both datasets were experimented on a traditional 2-layer neural network (NN) and a 5-layer deep neural network (DNN), with odd dropout neurons distribution resulting in the following configurations: NN (Parienti et al., 2004) [32], NN (Deniz et al., 2018) [53] and DNN [9 7 5 3 1]. To discern knowledge of failed treatment, DNN1 [9 7 5 3 1] and DNN2 [9 7 5 3 1] were introduced to model both datasets and only TCEs of patients at risk of drug resistance, respectively. Classification results revealed fewer misclassifications, with the DNN architecture yielding best performance measures. However, the transfer learning approach with DNN2 [9 7 3 1] configuration produced superior classification results when compared to other variants/configurations, with classification accuracy of 99.40%, and RMSE values of 0.0056, 0.0510, and 0.0362, for test, train, and overall datasets, respectively. The proposed system therefore indicates good generalization and is vital as decision-making support to clinicians/physicians for predicting patients at risk of adverse drug reactions. Although imbalanced features classification is typical of disease problems and diminishes dependence on classification accuracy, the proposed system still compared favorably with the literature and can be hybridized to improve its precision and recall rates.Publisher PDFPeer reviewe

Quality of Service Controlled Multimedia Transport Protocol

PhDThis research looks at the design of an open transport protocol that supports a range of services including multimedia over low data-rate networks. Low data-rate multimedia applications require a system that provides quality of service (QoS) assurance and flexibility. One promising field is the area of content-based coding. Content-based systems use an array of protocols to select the optimum set of coding algorithms. A content-based transport protocol integrates a content-based application to a transmission network. General transport protocols form a bottleneck in low data-rate multimedia communicationbsy limiting throughpuot r by not maintainingt iming requirementsT. his work presents an original model of a transport protocol that eliminates the bottleneck by introducing a flexible yet efficient algorithm that uses an open approach to flexibility and holistic architectureto promoteQ oS.T he flexibility andt ransparenccyo mesi n the form of a fixed syntaxt hat providesa seto f transportp rotocols emanticsT. he mediaQ oSi s maintained by defining a generic descriptor. Overall, the structure of the protocol is based on a single adaptablea lgorithm that supportsa pplication independencen, etwork independencea nd quality of service. The transportp rotocol was evaluatedth rougha set of assessmentos:f f-line; off-line for a specific application; and on-line for a specific application. Application contexts used MPEG-4 test material where the on-line assessmenuts eda modified MPEG-4 pl; yer. The performanceo f the QoSc ontrolledt ransportp rotocoli s often bettert hano thers chemews hen appropriateQ oS controlledm anagemenatl gorithmsa re selectedT. his is shownf irst for an off-line assessmenwt here the performancei s compared between the QoS controlled multiplexer,a n emulatedM PEG-4F lexMux multiplexers chemea, ndt he targetr equirements. The performanceis also shownt o be better in a real environmentw hen the QoS controlled multiplexeri s comparedw ith the real MPEG-4F lexMux scheme

PREDICTION OF RESPIRATORY MOTION

Radiation therapy is a cancer treatment method that employs high-energy radiation beams to destroy cancer cells by damaging the ability of these cells to reproduce. Thoracic and abdominal tumors may change their positions during respiration by as much as three centimeters during radiation treatment. The prediction of respiratory motion has become an important research area because respiratory motion severely affects precise radiation dose delivery. This study describes recent radiotherapy technologies including tools for measuring target position during radiotherapy and tracking-based delivery systems. In the first part of our study we review three prediction approaches of respiratory motion, i.e., model-based methods, model-free heuristic learning algorithms, and hybrid methods. In the second part of our work we propose respiratory motion estimation with hybrid implementation of extended Kalman filter. The proposed method uses the recurrent neural network as the role of the predictor and the extended Kalman filter as the role of the corrector. In the third part of our work we further extend our research work to present customized prediction of respiratory motion with clustering from multiple patient interactions. For the customized prediction we construct the clustering based on breathing patterns of multiple patients using the feature selection metrics that are composed of a variety of breathing features. In the fourth part of our work we retrospectively categorize breathing data into several classes and propose a new approach to detect irregular breathing patterns using neural networks. We have evaluated the proposed new algorithm by comparing the prediction overshoot and the tracking estimation value. The experimental results of 448 patients’ breathing patterns validated the proposed irregular breathing classifier

Advances in PID Control

Since the foundation and up to the current state-of-the-art in control engineering, the problems of PID control steadily attract great attention of numerous researchers and remain inexhaustible source of new ideas for process of control system design and industrial applications. PID control effectiveness is usually caused by the nature of dynamical processes, conditioned that the majority of the industrial dynamical processes are well described by simple dynamic model of the first or second order. The efficacy of PID controllers vastly falls in case of complicated dynamics, nonlinearities, and varying parameters of the plant. This gives a pulse to further researches in the field of PID control. Consequently, the problems of advanced PID control system design methodologies, rules of adaptive PID control, self-tuning procedures, and particularly robustness and transient performance for nonlinear systems, still remain as the areas of the lively interests for many scientists and researchers at the present time. The recent research results presented in this book provide new ideas for improved performance of PID control applications

Recent Advances in Signal Processing

The signal processing task is a very critical issue in the majority of new technological inventions and challenges in a variety of applications in both science and engineering fields. Classical signal processing techniques have largely worked with mathematical models that are linear, local, stationary, and Gaussian. They have always favored closed-form tractability over real-world accuracy. These constraints were imposed by the lack of powerful computing tools. During the last few decades, signal processing theories, developments, and applications have matured rapidly and now include tools from many areas of mathematics, computer science, physics, and engineering. This book is targeted primarily toward both students and researchers who want to be exposed to a wide variety of signal processing techniques and algorithms. It includes 27 chapters that can be categorized into five different areas depending on the application at hand. These five categories are ordered to address image processing, speech processing, communication systems, time-series analysis, and educational packages respectively. The book has the advantage of providing a collection of applications that are completely independent and self-contained; thus, the interested reader can choose any chapter and skip to another without losing continuity

Residential Demand Response using Electricity Smart Meter Data

The electricity industry is currently undergoing changes in a transitioning period characterised by Energy 3D: Digitalisation, Decentralisation, and Decarbonisation. Smart meters are the vital infrastructure necessary to digitalise the energy system as well as enable advancements in decentralisation and decarbonisation. As of today, more than 500 million smart meters have been installed worldwide, with that number expected to rise to several billion installations over the decade. Smart meters enable electricity load to be measured with half-hourly granularity, providing an opportunity for demand-side management innovations that are likely to be advantageous for both utility companies and customers. Among these innovations, time-of- use (TOU) tariffs are widely considered to be the most promising solution for optimising energy consumption in the residential sector, however actual use is still limited. The objective of this thesis is to investigate opportunities and problems related to TOU tariffs utilising smart meter data at the national level. The authors have identified four major research gaps which need to be filled in order to expand commercial applications of TOU tariffs. These gaps are the described and addressed in the following chapters: the "TOU load adaptation forecasting problem", the "TOU winner detection problem", the "TOU public dataset problem", and the "excess generation forecasting problem". This thesis demonstrates three modelling approaches and one new TOU dataset (CAMSL). A significant contribution to the field is through the discover of new summary statistical features (statistical moments) and assesses the capacity of these to encapsulate other more widely used explanatory variables of demand response. The thesis is concluded by discussing future works and policy implications, such as the necessity of the more tailored modelling works and public live-stream of smart meter data, which could accelerate the roll-out of the demand side management at the residential sector.EPC

Desarrollo y validación de un modelo dinámico para una pila de combustible tipo PEM

JORNADAS DE AUTOMÁTICA (27) (27.2006.ALMERÍA)El objetivo de este trabajo es realizar un modelo dinámico detallado de una pila de combustible tipo PEM de 1.2 kW de potencia nominal. El modelo desarrollado incluye efectos como el ’flooding’ y la dinámica de la temperatura y es de utilidad para poder diseñar y ensayar controles tanto de la válvula de purga como de la refrigeración de la pila mediante un ventilador. Se ha desarrollado un novedoso tratamiento de la ecuación experimental que modela la curva de polarización que simplifica considerablemente su caracterización. Por último el modelo realizado ha sido validado con datos tomados de una pila real

Mobile Ad Hoc Networks

Guiding readers through the basics of these rapidly emerging networks to more advanced concepts and future expectations, Mobile Ad hoc Networks: Current Status and Future Trends identifies and examines the most pressing research issues in Mobile Ad hoc Networks (MANETs). Containing the contributions of leading researchers, industry professionals, and academics, this forward-looking reference provides an authoritative perspective of the state of the art in MANETs. The book includes surveys of recent publications that investigate key areas of interest such as limited resources and the mobility of mobile nodes. It considers routing, multicast, energy, security, channel assignment, and ensuring quality of service. Also suitable as a text for graduate students, the book is organized into three sections: Fundamentals of MANET Modeling and Simulation—Describes how MANETs operate and perform through simulations and models Communication Protocols of MANETs—Presents cutting-edge research on key issues, including MAC layer issues and routing in high mobility Future Networks Inspired By MANETs—Tackles open research issues and emerging trends Illustrating the role MANETs are likely to play in future networks, this book supplies the foundation and insight you will need to make your own contributions to the field. It includes coverage of routing protocols, modeling and simulations tools, intelligent optimization techniques to multicriteria routing, security issues in FHAMIPv6, connecting moving smart objects to the Internet, underwater sensor networks, wireless mesh network architecture and protocols, adaptive routing provision using Bayesian inference, and adaptive flow control in transport layer using genetic algorithms

Bioinspired metaheuristic algorithms for global optimization

This paper presents concise comparison study of newly developed bioinspired algorithms for global optimization problems. Three different metaheuristic techniques, namely Accelerated Particle Swarm Optimization (APSO), Firefly Algorithm (FA), and Grey Wolf Optimizer (GWO) are investigated and implemented in Matlab environment. These methods are compared on four unimodal and multimodal nonlinear functions in order to find global optimum values. Computational results indicate that GWO outperforms other intelligent techniques, and that all aforementioned algorithms can be successfully used for optimization of continuous functions