Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms.

BackgroundAlthough differences in brain anatomy in autism have been difficult to replicate using manual tracing methods, automated whole brain analyses have begun to find consistent differences in regions of the brain associated with the social cognitive processes that are often impaired in autism. We attempted to replicate these whole brain studies and to correlate regional volume changes with several autism symptom measures.MethodsWe performed MRI scans on 24 individuals diagnosed with DSM-IV autistic disorder and compared those to scans from 23 healthy comparison subjects matched on age. All participants were male. Whole brain, voxel-wise analyses of regional gray matter volume were conducted using voxel-based morphometry (VBM).ResultsControlling for age and total gray matter volume, the volumes of the medial frontal gyri, left pre-central gyrus, right post-central gyrus, right fusiform gyrus, caudate nuclei and the left hippocampus were larger in the autism group relative to controls. Regions exhibiting smaller volumes in the autism group were observed exclusively in the cerebellum. Significant partial correlations were found between the volumes of the caudate nuclei, multiple frontal and temporal regions, the cerebellum and a measure of repetitive behaviors, controlling for total gray matter volume. Social and communication deficits in autism were also associated with caudate, cerebellar, and precuneus volumes, as well as with frontal and temporal lobe regional volumes.ConclusionGray matter enlargement was observed in areas that have been functionally identified as important in social-cognitive processes, such as the medial frontal gyri, sensorimotor cortex and middle temporal gyrus. Additionally, we have shown that VBM is sensitive to associations between social and repetitive behaviors and regional brain volumes in autism

Foveated Path Tracing with Fast Reconstruction and Efficient Sample Distribution

Polunseuranta on tietokonegrafiikan piirtotekniikka, jota on käytetty pääasiassa ei-reaaliaikaisen realistisen piirron tekemiseen. Polunseuranta tukee luonnostaan monia muilla tekniikoilla vaikeasti saavutettavia todellisen valon ilmiöitä kuten heijastuksia ja taittumista. Reaaliaikainen polunseuranta on hankalaa polunseurannan suuren laskentavaatimuksen takia. Siksi nykyiset reaaliaikaiset polunseurantasysteemi tuottavat erittäin kohinaisia kuvia, jotka tyypillisesti suodatetaan jälkikäsittelykohinanpoisto-suodattimilla. Erittäin immersiivisiä käyttäjäkokemuksia voitaisiin luoda polunseurannalla, joka täyttäisi laajennetun todellisuuden vaatimukset suuresta resoluutiosta riittävän matalassa vasteajassa. Yksi mahdollinen ratkaisu näiden vaatimusten täyttämiseen voisi olla katsekeskeinen polunseuranta, jossa piirron resoluutiota vähennetään katseen reunoilla. Tämän johdosta piirron laatu on katseen reunoilla sekä harvaa että kohinaista, mikä asettaa suuren roolin lopullisen kuvan koostavalle suodattimelle. Tässä työssä esitellään ensimmäinen reaaliajassa toimiva regressionsuodatin. Suodatin on suunniteltu kohinaisille kuville, joissa on yksi polunseurantanäyte pikseliä kohden. Nopea suoritus saavutetaan tiileissä käsittelemällä ja nopealla sovituksen toteutuksella. Lisäksi työssä esitellään Visual-Polar koordinaattiavaruus, joka jakaa polunseurantanäytteet siten, että niiden jakauma seuraa silmän herkkyysmallia. Visual-Polar-avaruuden etu muihin tekniikoiden nähden on että se vähentää työmäärää sekä polunseurannassa että suotimessa. Nämä tekniikat esittelevät toimivan prototyypin katsekeskeisestä polunseurannasta, ja saattavat toimia tienraivaajina laajamittaiselle realistisen reaaliaikaisen polunseurannan käyttöönotolle.Photo-realistic offline rendering is currently done with path tracing, because it naturally produces many real-life light effects such as reflections, refractions and caustics. These effects are hard to achieve with other rendering techniques. However, path tracing in real time is complicated due to its high computational demand. Therefore, current real-time path tracing systems can only generate very noisy estimate of the final frame, which is then denoised with a post-processing reconstruction filter. A path tracing-based rendering system capable of filling the high resolution in the low latency requirements of mixed reality devices would generate a very immersive user experience. One possible solution for fulfilling these requirements could be foveated path tracing, wherein the rendering resolution is reduced in the periphery of the human visual system. The key challenge is that the foveated path tracing in the periphery is both sparse and noisy, placing high demands on the reconstruction filter. This thesis proposes the first regression-based reconstruction filter for path tracing that runs in real time. The filter is designed for highly noisy one sample per pixel inputs. The fast execution is accomplished with blockwise processing and fast implementation of the regression. In addition, a novel Visual-Polar coordinate space which distributes the samples according to the contrast sensitivity model of the human visual system is proposed. The specialty of Visual-Polar space is that it reduces both path tracing and reconstruction work because both of them can be done with smaller resolution. These techniques enable a working prototype of a foveated path tracing system and may work as a stepping stone towards wider commercial adoption of photo-realistic real-time path tracing

Stars in their eyes: What eye-tracking reveal about multimedia perceptual quality

Perceptual multimedia quality is of paramount importance to the continued take-up and proliferation of multimedia applications: users will not use and pay for applications if they are perceived to be of low quality. Whilst traditionally distributed multimedia quality has been characterised by Quality of Service (QoS) parameters, these neglect the user perspective of the issue of quality. In order to redress this shortcoming, we characterise the user multimedia perspective using the Quality of Perception (QoP) metric, which encompasses not only a user’s satisfaction with the quality of a multimedia presentation, but also his/her ability to analyse, synthesise and assimilate informational content of multimedia. In recognition of the fact that monitoring eye movements offers insights into visual perception, as well as the associated attention mechanisms and cognitive processes, this paper reports on the results of a study investigating the impact of differing multimedia presentation frame rates on user QoP and eye path data. Our results show that provision of higher frame rates, usually assumed to provide better multimedia presentation quality, do not significantly impact upon the median coordinate value of eye path data. Moreover, higher frame rates do not significantly increase level of participant information assimilation, although they do significantly improve overall user enjoyment and quality perception of the multimedia content being shown

Analysis of retinotectal regeneration in goldfish using polar dimensions: temporal sequence and spatial order

Quantitative analysis of electrophysiological visuotectal maps using polar dimensions demonstrated uniform representation of visual field on goldfish optic tectum, with topography equally precise in normal and "mature" regenerated projections. The precision of circumferential topography exceeds and is not correlated with that of radial. Radial orderliness may he poor without diminution of circumferential order: these two dimensions of pattern could he generated separately from each other. The method of analysis also allows quantitation of the orientation of the retinotectal projection. During development radial retinotopy in the sequence of axon growth could contribute to radial topography by confining optic terminals to specific annuli within the projection. The possibility of pattern formation by this means during regeneration was studied by examining the sequence of fibre growth by retrograde labelling of ganglion cells with horseradish peroxidase (HRP), applied to a cut through the optic tract at successive intervals after optic nerve transection in mid-orbit. Most results indicated a central-to-peripheral sequence of regeneration; others showed absence of retinotopic sequence. Regeneration of axons from central retina was delayed by repetition of axotomy. Subsequent visuotectal maps were either normal or included electrophysiologically weak representation of central visual field on peripheral tectum, outside or superimposed upon the map of peripheral field. Some of the abnormal maps also contained normal representation of central field on central tectum. Because of the contradictions in these results, the influence of temporal sequence on spatial order of connections remains uncertain. Formation of circumferential topography was investigated by anterograde tracing with HRP of axons from narrow sectors of retina in normal and regenerated pathways. Juxtaposition of labelled axons appears to be completely lost in the optic chiasm or at the site of optic nerve transection. Contact guidance of axons therefore cannot explain circumferential order in the map. Labelling was inadequate to show whether regenerating fibres resegregate retinotopically in the optic tract

3D head motion, point-of-regard and encoded gaze fixations in real scenes: next-generation portable video-based monocular eye tracking

Portable eye trackers allow us to see where a subject is looking when performing a natural task with free head and body movements. These eye trackers include headgear containing a camera directed at one of the subject\u27s eyes (the eye camera) and another camera (the scene camera) positioned above the same eye directed along the subject\u27s line-of-sight. The output video includes the scene video with a crosshair depicting where the subject is looking -- the point-of-regard (POR) -- that is updated for each frame. This video may be the desired final result or it may be further analyzed to obtain more specific information about the subject\u27s visual strategies. A list of the calculated POR positions in the scene video can also be analyzed. The goals of this project are to expand the information that we can obtain from a portable video-based monocular eye tracker and to minimize the amount of user interaction required to obtain and analyze this information. This work includes offline processing of both the eye and scene videos to obtain robust 2D PORs in scene video frames, identify gaze fixations from these PORs, obtain 3D head motion and ray trace fixations through volumes-of-interest (VOIs) to determine what is being fixated, when and where (3D POR). To avoid the redundancy of ray tracing a 2D POR in every video frame and to group these POR data meaningfully, a fixation-identification algorithm is employed to simplify the long list of 2D POR data into gaze fixations. In order to ray trace these fixations, the 3D motion -- position and orientation over time -- of the scene camera is computed. This camera motion is determined via an iterative structure and motion recovery algorithm that requires a calibrated camera and knowledge of the 3D location of at least four points in the scene (that can be selected from premeasured VOI vertices). The subjects 3D head motion is obtained directly from this camera motion. For the final stage of the algorithm, the 3D locations and dimensions of VOIs in the scene are required. This VOI information in world coordinates is converted to camera coordinates for ray tracing. A representative 2D POR position for each fixation is converted from image coordinates to the same camera coordinate system. Then, a ray is traced from the camera center through this position to determine which (if any) VOI is being fixated and where it is being fixated -- the 3D POR in the world. Results are presented for various real scenes. Novel visualizations of portable eye tracker data created using the results of our algorithm are also presented

Hand eye coordination in surgery

The coordination of the hand in response to visual target selection has always been regarded as an essential quality in a range of professional activities. This quality has thus far been elusive to objective scientific measurements, and is usually engulfed in the overall performance of the individuals. Parallels can be drawn to surgery, especially Minimally Invasive Surgery (MIS), where the physical constraints imposed by the arrangements of the instruments and visualisation methods require certain coordination skills that are unprecedented. With the current paradigm shift towards early specialisation in surgical training and shortened focused training time, selection process should identify trainees with the highest potentials in certain specific skills. Although significant effort has been made in objective assessment of surgical skills, it is only currently possible to measure surgeons’ abilities at the time of assessment. It has been particularly difficult to quantify specific details of hand-eye coordination and assess innate ability of future skills development. The purpose of this thesis is to examine hand-eye coordination in laboratory-based simulations, with a particular emphasis on details that are important to MIS. In order to understand the challenges of visuomotor coordination, movement trajectory errors have been used to provide an insight into the innate coordinate mapping of the brain. In MIS, novel spatial transformations, due to a combination of distorted endoscopic image projections and the “fulcrum” effect of the instruments, accentuate movement generation errors. Obvious differences in the quality of movement trajectories have been observed between novices and experts in MIS, however, this is difficult to measure quantitatively. A Hidden Markov Model (HMM) is used in this thesis to reveal the underlying characteristic movement details of a particular MIS manoeuvre and how such features are exaggerated by the introduction of rotation in the endoscopic camera. The proposed method has demonstrated the feasibility of measuring movement trajectory quality by machine learning techniques without prior arbitrary classification of expertise. Experimental results have highlighted these changes in novice laparoscopic surgeons, even after a short period of training. The intricate relationship between the hands and the eyes changes when learning a skilled visuomotor task has been previously studied. Reactive eye movement, when visual input is used primarily as a feedback mechanism for error correction, implies difficulties in hand-eye coordination. As the brain learns to adapt to this new coordinate map, eye movements then become predictive of the action generated. The concept of measuring this spatiotemporal relationship is introduced as a measure of hand-eye coordination in MIS, by comparing the Target Distance Function (TDF) between the eye fixation and the instrument tip position on the laparoscopic screen. Further validation of this concept using high fidelity experimental tasks is presented, where higher cognitive influence and multiple target selection increase the complexity of the data analysis. To this end, Granger-causality is presented as a measure of the predictability of the instrument movement with the eye fixation pattern. Partial Directed Coherence (PDC), a frequency-domain variation of Granger-causality, is used for the first time to measure hand-eye coordination. Experimental results are used to establish the strengths and potential pitfalls of the technique. To further enhance the accuracy of this measurement, a modified Jensen-Shannon Divergence (JSD) measure has been developed for enhancing the signal matching algorithm and trajectory segmentations. The proposed framework incorporates high frequency noise filtering, which represents non-purposeful hand and eye movements. The accuracy of the technique has been demonstrated by quantitative measurement of multiple laparoscopic tasks by expert and novice surgeons. Experimental results supporting visual search behavioural theory are presented, as this underpins the target selection process immediately prior to visual motor action generation. The effects of specialisation and experience on visual search patterns are also examined. Finally, pilot results from functional brain imaging are presented, where the Posterior Parietal Cortical (PPC) activation is measured using optical spectroscopy techniques. PPC has been demonstrated to involve in the calculation of the coordinate transformations between the visual and motor systems, which establishes the possibilities of exciting future studies in hand-eye coordination

Applied Cognitive Sciences

Cognitive science is an interdisciplinary field in the study of the mind and intelligence. The term cognition refers to a variety of mental processes, including perception, problem solving, learning, decision making, language use, and emotional experience. The basis of the cognitive sciences is the contribution of philosophy and computing to the study of cognition. Computing is very important in the study of cognition because computer-aided research helps to develop mental processes, and computers are used to test scientific hypotheses about mental organization and functioning. This book provides a platform for reviewing these disciplines and presenting cognitive research as a separate discipline

Hopfield Networks in Relevance and Redundancy Feature Selection Applied to Classification of Biomedical High-Resolution Micro-CT Images

We study filter–based feature selection methods for classification of biomedical images. For feature selection, we use two filters — a relevance filter which measures usefulness of individual features for target prediction, and a redundancy filter, which measures similarity between features. As selection method that combines relevance and redundancy we try out a Hopfield network. We experimentally compare selection methods, running unitary redundancy and relevance filters, against a greedy algorithm with redundancy thresholds [9], the min-redundancy max-relevance integration [8,23,36], and our Hopfield network selection. We conclude that on the whole, Hopfield selection was one of the most successful methods, outperforming min-redundancy max-relevance when\ud more features are selected