Doctor of Philosophy

dissertationAs the base of the software stack, system-level software is expected to provide ecient and scalable storage, communication, security and resource management functionalities. However, there are many computationally expensive functionalities at the system level, such as encryption, packet inspection, and error correction. All of these require substantial computing power. What's more, today's application workloads have entered gigabyte and terabyte scales, which demand even more computing power. To solve the rapidly increased computing power demand at the system level, this dissertation proposes using parallel graphics pro- cessing units (GPUs) in system software. GPUs excel at parallel computing, and also have a much faster development trend in parallel performance than central processing units (CPUs). However, system-level software has been originally designed to be latency-oriented. GPUs are designed for long-running computation and large-scale data processing, which are throughput-oriented. Such mismatch makes it dicult to t the system-level software with the GPUs. This dissertation presents generic principles of system-level GPU computing developed during the process of creating our two general frameworks for integrating GPU computing in storage and network packet processing. The principles are generic design techniques and abstractions to deal with common system-level GPU computing challenges. Those principles have been evaluated in concrete cases including storage and network packet processing applications that have been augmented with GPU computing. The signicant performance improvement found in the evaluation shows the eectiveness and eciency of the proposed techniques and abstractions. This dissertation also presents a literature survey of the relatively young system-level GPU computing area, to introduce the state of the art in both applications and techniques, and also their future potentials

Molecular dynamics simulations through GPU video games technologies

Bioinformatics is the scientific field that focuses on the application of computer technology to the management of biological information. Over the years, bioinformatics applications have been used to store, process and integrate biological and genetic information, using a wide range of methodologies. One of the most de novo techniques used to understand the physical movements of atoms and molecules is molecular dynamics (MD). MD is an in silico method to simulate the physical motions of atoms and molecules under certain conditions. This has become a state strategic technique and now plays a key role in many areas of exact sciences, such as chemistry, biology, physics and medicine. Due to their complexity, MD calculations could require enormous amounts of computer memory and time and therefore their execution has been a big problem. Despite the huge computational cost, molecular dynamics have been implemented using traditional computers with a central memory unit (CPU). A graphics processing unit (GPU) computing technology was first designed with the goal to improve video games, by rapidly creating and displaying images in a frame buffer such as screens. The hybrid GPU-CPU implementation, combined with parallel computing is a novel technology to perform a wide range of calculations. GPUs have been proposed and used to accelerate many scientific computations including MD simulations. Herein, we describe the new methodologies developed initially as video games and how they are now applied in MD simulations

Accelerated volumetric reconstruction from uncalibrated camera views

While both work with images, computer graphics and computer vision are inverse problems. Computer graphics starts traditionally with input geometric models and produces image sequences. Computer vision starts with input image sequences and produces geometric models. In the last few years, there has been a convergence of research to bridge the gap between the two fields. This convergence has produced a new field called Image-based Rendering and Modeling (IBMR). IBMR represents the effort of using the geometric information recovered from real images to generate new images with the hope that the synthesized ones appear photorealistic, as well as reducing the time spent on model creation. In this dissertation, the capturing, geometric and photometric aspects of an IBMR system are studied. A versatile framework was developed that enables the reconstruction of scenes from images acquired with a handheld digital camera. The proposed system targets applications in areas such as Computer Gaming and Virtual Reality, from a lowcost perspective. In the spirit of IBMR, the human operator is allowed to provide the high-level information, while underlying algorithms are used to perform low-level computational work. Conforming to the latest architecture trends, we propose a streaming voxel carving method, allowing a fast GPU-based processing on commodity hardware

Classification of the difficulty in accelerating problems using GPUs

Scientists continually require additional processing power, as this enables them to compute larger problem sizes, use more complex models and algorithms, and solve problems previously thought computationally impractical. General-purpose computation on graphics processing units (GPGPU) can help in this regard, as there is great potential in using graphics processors to accelerate many scientific models and algorithms. However, some problems are considerably harder to accelerate than others, and it may be challenging for those new to GPGPU to ascertain the difficulty of accelerating a particular problem or seek appropriate optimisation guidance. Through what was learned in the acceleration of a hydrological uncertainty ensemble model, large numbers of k-difference string comparisons, and a radix sort, problem attributes have been identified that can assist in the evaluation of the difficulty in accelerating a problem using GPUs. The identified attributes are inherent parallelism, branch divergence, problem size, required computational parallelism, memory access pattern regularity, data transfer overhead, and thread cooperation. Using these attributes as difficulty indicators, an initial problem difficulty classification framework has been created that aids in GPU acceleration difficulty evaluation. This framework further facilitates directed guidance on suggested optimisations and required knowledge based on problem classification, which has been demonstrated for the aforementioned accelerated problems. It is anticipated that this framework, or a derivative thereof, will prove to be a useful resource for new or novice GPGPU developers in the evaluation of potential problems for GPU acceleration

Classification of the difficulty in accelerating problems using GPUs

Scientists continually require additional processing power, as this enables them to compute larger problem sizes, use more complex models and algorithms, and solve problems previously thought computationally impractical. General-purpose computation on graphics processing units (GPGPU) can help in this regard, as there is great potential in using graphics processors to accelerate many scientific models and algorithms. However, some problems are considerably harder to accelerate than others, and it may be challenging for those new to GPGPU to ascertain the difficulty of accelerating a particular problem or seek appropriate optimisation guidance. Through what was learned in the acceleration of a hydrological uncertainty ensemble model, large numbers of k-difference string comparisons, and a radix sort, problem attributes have been identified that can assist in the evaluation of the difficulty in accelerating a problem using GPUs. The identified attributes are inherent parallelism, branch divergence, problem size, required computational parallelism, memory access pattern regularity, data transfer overhead, and thread cooperation. Using these attributes as difficulty indicators, an initial problem difficulty classification framework has been created that aids in GPU acceleration difficulty evaluation. This framework further facilitates directed guidance on suggested optimisations and required knowledge based on problem classification, which has been demonstrated for the aforementioned accelerated problems. It is anticipated that this framework, or a derivative thereof, will prove to be a useful resource for new or novice GPGPU developers in the evaluation of potential problems for GPU acceleration

High Performance Computing for DNA Sequence Alignment and Assembly

Recent advances in DNA sequencing technology have dramatically increased the scale and scope of DNA sequencing. These data are used for a wide variety of important biological analyzes, including genome sequencing, comparative genomics, transcriptome analysis, and personalized medicine but are complicated by the volume and complexity of the data involved. Given the massive size of these datasets, computational biology must draw on the advances of high performance computing. Two fundamental computations in computational biology are read alignment and genome assembly. Read alignment maps short DNA sequences to a reference genome to discover conserved and polymorphic regions of the genome. Genome assembly computes the sequence of a genome from many short DNA sequences. Both computations benefit from recent advances in high performance computing to efficiently process the huge datasets involved, including using highly parallel graphics processing units (GPUs) as high performance desktop processors, and using the MapReduce framework coupled with cloud computing to parallelize computation to large compute grids. This dissertation demonstrates how these technologies can be used to accelerate these computations by orders of magnitude, and have the potential to make otherwise infeasible computations practical

Improving Utility of GPU in Accelerating Industrial Applications with User-centred Automatic Code Translation

SMEs (Small and medium-sized enterprises), particularly those whose business is focused on developing innovative produces, are limited by a major bottleneck on the speed of computation in many applications. The recent developments in GPUs have been the marked increase in their versatility in many computational areas. But due to the lack of specialist GPU (Graphics processing units) programming skills, the explosion of GPU power has not been fully utilized in general SME applications by inexperienced users. Also, existing automatic CPU-to-GPU code translators are mainly designed for research purposes with poor user interface design and hard-to-use. Little attentions have been paid to the applicability, usability and learnability of these tools for normal users. In this paper, we present an online automated CPU-to-GPU source translation system, (GPSME) for inexperienced users to utilize GPU capability in accelerating general SME applications. This system designs and implements a directive programming model with new kernel generation scheme and memory management hierarchy to optimize its performance. A web-service based interface is designed for inexperienced users to easily and flexibly invoke the automatic resource translator. Our experiments with non-expert GPU users in 4 SMEs reflect that GPSME system can efficiently accelerate real-world applications with at least 4x and have a better applicability, usability and learnability than existing automatic CPU-to-GPU source translators

IMPROVING BWA-MEM WITH GPU PARALLEL COMPUTING

Due to the many advances made in designing algorithms, especially the ones used in bioinformatics, it is becoming harder and harder to improve their efficiencies. Therefore, hardware acceleration using General-Purpose computing on Graphics Processing Unit has become a popular choice. BWA-MEM is an important part of the BWA software package for sequence mapping. Because of its high speed and accuracy, we choose to parallelize the popular short DNA sequence mapper. BWA has been a prevalent single node tool in genome alignment, and it has been widely studied for acceleration for a long time since the first version of the BWA package came out. This thesis presents the Big Data GPGPU distributed BWA-MEM, a tool that combines GPGPU acceleration and distributed computing. The four hardware parallelization techniques used are CPU multi-threading, GPU paralleled, CPU distributed, and GPU distributed. The GPGPU distributed software typically outperforms other parallelization versions. The alignment is performed on a distributed network, and each node in the network executes a separate GPGPU paralleled version of the software. We parallelize the chain2aln function in three levels. In Level 1, the function ksw\_extend2, an algorithm based on Smith-Waterman, is parallelized to handle extension on one side of the seed. In Level 2, the function chain2aln is parallelized to handle chain extension, where all seeds within the same chain are extended. In Level 3, part of the function mem\_align1\_core is parallelized for extending multiple chains. Due to the program's complexity, the parallelization work was limited at the GPU version of ksw\_extend2 parallelization Level 3. However, we have successfully combined Spark with BWA-MEM and ksw\_extend2 at parallelization Level 1, which has shown that the proposed framework is possible. The paralleled Level 3 GPU version of ksw\_extend2 demonstrated noticeable speed improvement with the test data set