Simulating Humans as Integral Parts of Spacecraft Missions

The Collaborative-Virtual Environment Simulation Tool (C-VEST) software was developed for use in a NASA project entitled "3-D Interactive Digital Virtual Human." The project is oriented toward the use of a comprehensive suite of advanced software tools in computational simulations for the purposes of human-centered design of spacecraft missions and of the spacecraft, space suits, and other equipment to be used on the missions. The C-VEST software affords an unprecedented suite of capabilities for three-dimensional virtual-environment simulations with plug-in interfaces for physiological data, haptic interfaces, plug-and-play software, realtime control, and/or playback control. Mathematical models of the mechanics of the human body and of the aforementioned equipment are implemented in software and integrated to simulate forces exerted on and by astronauts as they work. The computational results can then support the iterative processes of design, building, and testing in applied systems engineering and integration. The results of the simulations provide guidance for devising measures to counteract effects of microgravity on the human body and for the rapid development of virtual (that is, simulated) prototypes of advanced space suits, cockpits, and robots to enhance the productivity, comfort, and safety of astronauts. The unique ability to implement human-in-the-loop immersion also makes the C-VEST software potentially valuable for use in commercial and academic settings beyond the original space-mission setting

Recombination in the Open-Ended Value Landscape of Digital Innovation

Digital innovation introduces a new open-ended value landscape to anyone seeking to generate or capture new value. To understand this landscape, we distinguish between design recombination and use recombination, explore how they play out together, and redirect the attention from products and services toward digital resources. Digital resources serve as building-blocks in digital innovation, and they hold the potential to simultaneously be part of multiple value paths, offered through design recombination and assembled through use recombination. Building on this perspective, we offer the value spaces framework as a tool for better understanding value creation and capture in digital innovation. We illustrate the framework and offer the early contours of a research agenda for information systems researchers

Plug & Test at System Level via Testable TLM Primitives

With the evolution of Electronic System Level (ESL) design methodologies, we are experiencing an extensive use of Transaction-Level Modeling (TLM). TLM is a high-level approach to modeling digital systems where details of the communication among modules are separated from the those of the implementation of functional units. This paper represents a first step toward the automatic insertion of testing capabilities at the transaction level by definition of testable TLM primitives. The use of testable TLM primitives should help designers to easily get testable transaction level descriptions implementing what we call a "Plug & Test" design methodology. The proposed approach is intended to work both with hardware and software implementations. In particular, in this paper we will focus on the design of a testable FIFO communication channel to show how designers are given the freedom of trading-off complexity, testability levels, and cos

Emerging Trends of Nanotechnology towards Picotechnology: Energy and Biomolecules

In nature, metal oxide particles display their existence at the level of picomolecules in solution state and bioactive states in the body. We present evidence of picomolar behavior of molecules different than nanomolar behavior of particles. These particles can be encapsulated in polymers and can be functionalized with protein, nucleotides, and drugs to develop as smart intracellular targeting pico-devices. The preparation technique and physiological conditions decide the size and functionality of these pico-carrier devices. Their usable success rate, feasibility and potentials are yet to be proven or we do not know. The major difference between nanodevices and pico-devices is their intermolecular and intramolecular thermodynamics in medium and their molecular conformational interaction with molecular assembly in cytoarchitecture of the neurofilament, actin-myosin, microtubule proteins. Pico-carrier devices can be presumed as potential spears without interacting with host signal transduction and immunoprotection. In conclusion, the ultrafine size of newer picotechnology products may be better suited and easier to functionalize for design of particle based picodrugs, picochemicals, and pico-targeting molecules